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Acrolein is an air toxic with high potency as a respiratory irritant. There is strikingly little epidemiology available for acrolein although US EPA estimates that acrolein is responsible for about 75 percent of non-cancer respiratory health effects attributable to air toxics in the United States, based on the Agency's 2005 National-Scale Air Toxics Assessment (NATA). We addressed this data gap by geographically linking 2005 NATA acrolein exposure estimates at the census tract with residences of participants in the National Health Interview Survey (NHIS) for 2000-2009 (n = 216,371). The NHIS monitors the health of the civilian, non-institutionalized population of the United States through a comprehensive interview of a nationally representative sample of households. The health outcome was self-reported asthma attack in the previous 12 months among adults 18 years and older. In the highest quintile of acrolein exposure (>0.055 ug/m3), there was a borderline statistically significant increase in asthma attack prevalence (pOR [95% CI]= 1.11 [1.00:1.23]), controlling for smoking, sex, age, education, race, poverty, insurance, access to care, urban/rural residence, and survey year. Stratifying the analysis by urban and rural residence, exposure to the highest quintile of acrolein concentration in urban areas was borderline statistically significant (1.13 [1.00:1.29]), while in rural areas it was not (1.08 [0.80:1.44]).