Adverse Food Reactions PDF

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Adverse Food Reactions PDF

  1. 1. Malabsorption of iron, folate,calcium and fat soluble vitaminsresults in iron deficiency, folatedeficiency and reduced bonedensity
  2. 2. Infants and young children
present with diarrhoea,
abdominal distension and
FAILURE TO THRIVE
  3. 3.   Calcium malabsorption  Vitamin D malabsorption  Secondary hyperparathyroidism  Failure of peak bone density as child  Reduced gonadal function in men  Autoimmunity
  4. 4.   Delayed menarche  Premature menopause  Amenorrhoea  recurrent miscarriages  Infertility & low birthweight babies  Increased perinatal mortality
  5. 5.   Coeliac Disease  Diabetes Mellitus  Autoimmune Thyroid Disease / MS  Rheumatoid Arthritis / Psoriasis  GlomerulonephritisAntibodies disappear on a gluten free diet
  6. 6. Anaemia AllergiesThyroid DiseaseLactose IntoleranceIBS, CFS
  7. 7.   IDDM  Addisons
  Thyroid disease Disease  Sjogrens
  Cardiomyopathy Disease  Neurological
  Renal Disease disorders  Autoimmune
 liver disease
  8. 8.   Antibodies against gliadin (IgA-AGA, IgG-AGA)  Endomysial antibody (IgA-EMA)  Tissue transglutaminase antibody (IgA-tTG) Total IgA
  9. 9. Malignant diseases are morefrequent in coeliacs Small bowel CA Oesophageal & oropharangeal CA Non-Hogkins lymphoma
  10. 10.   Autistic children respond to gluten-free,casein-free diet  Improved speech, social behaviour,
 sleeping habits  Food peptides affect ADHD  Depression & morphine-like exorphins
  11. 11. Oats are not toxic topatients with CoeliacDisease or DermatitisHerpetiformis
  12. 12.   Genetic link (HLA-DQ2 and HLA-DQ8)
 in patients with coeliac disease  Alpha-gliadin has immunoreactve
 peptides
  Hyphal wall protein (HWP 1) in
 C. albicans. Similar epitopes in gliadin
  13. 13.   Yeasts adhere to gut via transglutaminases  Gliadin deamidated via transglutaminases  Yeast & gluten provide T-cell epitopes (reactive peptides which trigger antibodies)  Autoreactive antibodies form against tissue
 transglutaminases and endomysium peptides
  14. 14.   Increased candida overgrowth  Damage to gut  Increased exposure of transglutaminases  Increased binding of candida HWP 1  Tissue transaminases (autoantigen)
 recognised by autoreactive antibodies
  15. 15.   Introduce gluten while breast feeding  Small quantities of gluten only  Keep breast feeding after gluten exposure  Breast feeding at exposure increases oral
 tolerance  Breast feeding protects against Diabetes
 type 1, IBS and Leukaemia
  16. 16. Uncommon,  Milk Allergy Small amounts trigger IgE mediated Reactions sudden Common Milk Normal amounts trigger Intolerance Not IgE mediated Skin tests Negative Reactions delayed (4-26 days)
  17. 17.   Masking- Remove dust, mould, dogs etc  Glue ear- Are parents atopic?  IBS- Milk & wheat increase rectal PGʼs  Asthma- Look for milk addiction  Eczema- >2 allergens (related to asthma)
  18. 18. Total Fat (% total energy) No IHD IHDFramington 38.8 40.0Puerto Rico (urban) 36.6 37.7Puerto Rico (rural) 32.2 32.0Honolulu 33.3 35.2London 40.5 40.0Zutphen 41.7 41.8Ireland/Boston 38.5 39.4Caerphilly 40.1 40.9
  19. 19.   Glucose-Galactose (disaccharide)  12g per 250ml milk  Reduced in yogurt/fermented milk  Absent in hard cheese  Intolerance when lactase deficient
  20. 20. Examination of 23,207 sets of coronary arteries and aortas revealed severity of atherosclerosis was related to: Highest daily milk consumption  hose with highest lactase activity T
  21. 21. Men 55-64 yrs had the samecholesterol and sat. fat intake(1950-1980) but IHD mortalitywas highest in Finland. Why?(Wine and ethanol intake was the same) The Finns drank 3.4 times
 more milk
  22. 22. During 1972-92 there was adramatic decline in IHD inFinland as milk consumptiondeclined . Cheese intake increased 3
 times during this period
  23. 23.   Japan,China, Greenland Eskimos 
 (heavy smokers, low wine intake)  Masai of East Africa (drink fermented 
 milk low in lactose)  South African Blacks, Afro-Carribeans,
 Prima Indians, Shri Lankans (low
 milk,low lactose) North Indians, Pakistanis and British have elevated IHD, high milk intake and high lactase levels
  24. 24. Milk intake - 66% less than UKFat intake - 33% more than UKCheese intake 300% more than fresh milkLactase activity: Northern France - 50% less than Europe Southern France - 25% less than Europe
  25. 25. Galactose (and Fructose)preferentially glycate proteinsespecially LDL.This makes LDL moresusceptible to oxidation andthus atherosclerosis
  26. 26. Is high lactoseconsumption merely a marker for β-caseinintake?
  27. 27. “The rate of β-Casein A1 consumption (excluding cheese) is a more accurate predictor of heart disease…. Than that reported for traditional risk factors”
  28. 28. A survey of 39 centres in 26 countries   CHOLESTEROL   BLOOD PRESSURE   SATURATED FATS   OBESITY Varied in relative contribution to illness
  29. 29. 600 500 400 RelativeIndidence of 300 Diabetes 200 100 0 Low Milk High Milk Diet Diet
  30. 30. 40 35 Ulcer with 30 Sippy % 25 Ulcer with no Relative SippyIncidence of 20 Myocardial No Ulcer Infarct 15 10 5 0 USA Britain
  31. 31. 3.5 3 A1 2.5 Relative 2 Incidence ofHeart Disease 1.5 CHD A1 CHD 1 0.5 0 Toulouse Belfast
  32. 32. Rennet and subsequentenzymatic action as cheeseages causes alterations to the cheese protein structurecausing cross-linking ofcasein molecules.Casomorphin-7 is absent in most cheeses
  33. 33.   Casein causes heart disease in animals  Casein accelerates hypercholesterolaemia and atherosclerosis in animals Apo E deficient atherosclerosis prone mice
 get more lesions  Longevity in animals decreased by casein (compared with soy and whey) Pigs fed casein have elevated homocysteine

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