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February
Issue : 08
2023
An Insider
Psychological Explana on
to Pain Management
How to Overcome?
Effec ve Techniques
Used to Manage Pain
Artelo
Biosciences
Using Cu ng-Edge Science with Lipid-Signaling
Modula on to Improve Trea ng People with Cancer
Most
Promising
PAIN
in 2023
Management
SOLUTION
Providers
Gregory D. Gorgas
President,
Chief Execu ve Officer
Artelo Biosciences
Helping Technology
Technology
Technology
Work With You &
For You
For You
For You
Editor’s
Note
ain management is an ever-evolving field, with new
Ptreatments and technologies emerging all the time.
As the healthcare industry shifts towards a more
patient-centered approach, there is a growing need for pain
management solutions that are safe, effective and tailored to
individual patient needs.
One of the emerging trends in pain management is the use
of non-pharmacological interventions. With the growing
concern over opioid addiction and abuse, non-
pharmacological interventions like cognitive-behavioral
therapy, acupuncture and physical therapy are becoming
increasingly popular. These treatments are effective in
managing pain and have fewer side effects than traditional
pain medications.
Another promising trend is the use of digital health tools to
manage pain. The use of mobile apps and wearables to track
pain symptoms and medication usage is on the rise. These
tools provide patients with real-time data about their pain
levels and can help healthcare providers make more
informed decisions about treatment options.
Personalized medicine is also playing an important role in
the future of pain management. With advancements in
genomics and molecular biology, healthcare providers can
identify genetic variations that influence a patient's response
to pain medications. This information can be used to
develop personalized treatment plans that are more effective
and have fewer side effects.
Innovative medical devices and therapies are also
transforming pain management. Devices like spinal cord
stimulators and peripheral nerve stimulators can provide
relief for chronic pain sufferers. Emerging therapies like
stem cell treatments and regenerative medicine show great
promise in repairing damaged tissue and reducing
inflammation.
Finally, there is a growing recognition of the importance of
interdisciplinary care in pain management. A team-based
approach that includes healthcare providers from different
specialties, such as pain medicine, physical therapy and
psychology, can provide patients with comprehensive care
that addresses all aspects of their pain.
In Insights Care's latest edition Most Promising Pain
Management Solution Providers 2023, we bring to you a
comprehensive list of companies that are leading the charge
in providing innovative solutions to tackle pain
management, a critical issue that affects millions of people
worldwide.
Hope you have an interesting read!
-Pooja Shah
The Future of
Pain Management:
Emerging Trends and Innova ons
Artelo Biosciences
Using Cu ng-Edge Science with Lipid-Signaling
Modula on to Improve Trea ng People with Cancer
08
Ctts
Cover
Story
Ctts
Effec ve Techniques Used
to Manage Pain
How to Overcome?
32
Psychological Explana on
to Pain Management
An Insider
20
Aicl
Kipuwex Ltd.
Revolu onizing the Telehealth Industry
with a Pa ent-Centric Approach
16
Nen Evidence Based
Solution S.L.U. (nen)
A Pain Management Solu on,
Designed for Kids Figh ng Cancer
24
28 36
Soovu Labs, Inc.
Relieving Pain Through an
Innova ve Heat Delivery Approach
Rescape
Innovation Limited
Reducing Pain and Anxiety Through
Virtual Reality
Editor-in-Chief
Merry D'souza
Senior Editor
Anish Miller
Managing Editor
Pooja Shah
Assisting Editors
Saloni, Shreyasi
Visualiser
David King
Art & Design Head
Mrunalinee Deshmukh
Co-designer
Paul Belin
Art & Picture Editor
Sonia Raizada
Business Development
Manager
Amy Jones
Marketing Manager
John Smith
Business Development
Executives
Sarah Wilson, John Smith,
Alex Vincent
Sales Executives
Kelli, Bill, Anna
Technical Head
Jacob Smile
Assistant Technical Head
Prachi Mokashi
Technical Consultants
David, Robert
Digital Marketing
Manager
Alina Sege
Assistant Digital
Marketing Manager
Renuka Kulkarni
SME-SMO Executives
Gemson
Research Analyst
Eric Smith
Circulation Manager
Tanaji Fartade
Copyright © 2023 Insights Success Media and Technology Pvt. Ltd., All rights reserved. The content and images used in this magazine should not be reproduced or
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Reprint rights remain solely with Insights Success Media and Technology Pvt. Ltd. Insights Care is powered by Insights Success Media and Technology Pvt. Ltd.
February, 2023
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Most Promising Pain Management Solution Providers in 2023
Description
Company
Featuring
Person
Artelo
Biosciences, Inc.
Artelobio.com
Gregory D. Gorgas
CEO & President
Artelo Biosciences, Inc. is a clinical stage company focused
on modifying lipid-signaling pathways to improve
treatments for people living with cancer.
Bridges
Paliative Care
Bridgespalliativecare.com
Erik Soiferman
Owner
Bridges Paliative Care’s goal is to help you achieve the best
possible outcome and overall quality of life throughout your
illness.
DORN
Dorncompanies.com
Kevin Lombardo
President
CEO
DORN is a disruptive innovator and the country’s leading
wellness-based pain management and injury prevention
company, committed to reducing costs of healthcare,
workers’ compensation and lost productivity.
KIPUWEX OY LTD
Kipuwex.com
Marko Höynälä
CEO & Founder
KIPUWEX OY LTD is a small wireless IoT device that
continuously measures different physiological parameters
from the patient digitally, converting them with an
algorithm into pain data and provides efficiently reliable
measurements for healthcare professionals and home users.
Francesca Wuttke
/ Xenia Riasol
Founder & CEO /
COO
Nen provides evidence based health designed for
children’s minds to improve their lives.
Alan Doucet
Executive Director
Plymouth Bay Orthopedic Associates, Inc. goal is to help
patients live a more active and rewarding life.
Matt Wordley
CEO
Rescape California is a non-profit organization that
educates about and advocates for a whole-systems
approach to landscaping that works in harmony with the
natural world and addresses the changing environment.
Soovu Labs, Inc
Soovu.com
Allan Stephan
Co-founder and
CEO
Soovu Labs, Inc helps individuals overcome pain and get
back to their lives and work.
Nen
Nen.health
Plymouth Bay
Orthopedic
Associates, Inc.
Pbortho.com
Rescape
Rescape.health
Gregory D. Gorgas
President, Chief Execu ve Officer
Artelo Biosciences
Cover
STORY
cross the healthcare community, a serious
Achallenge while delivering care is assisting patients
with both acute and chronic pain management.
Particularly so for people living with cancer.
The initial stage of treating any disease or ailment is
diagnosing the cause and treating it with appropriate
interventions, including drugs or varied therapeutic
approaches as required. However, a standard diagnosis-
treatment-healing paradigm doesn’t always work well for a
person living with cancer.
Through the cancer treatment journey, a person diagnosed
with cancer may encounter considerable peripheral pain
(neuropathy), bone inflammation, gastrointestinal infection,
low musculoskeletal functionality, or other complications. A
2020 public health research indicates that around 20% to
50% of cancer survivors experience pain. Yet, 30% of those
who do not receive relief from their pain experience a
negative impact on their quality of life. As cancer advances,
pain can intensify by up to 80%, severely impacting a
person’s quality of life. These statistics motivate the
research community to discover new and robust solutions.
One potential alternative emerging from clinical research on
cancer pain has spotlighted the role of the body’s own
Endocannabinoid System (ECS). This cell-signaling
network is one of the largest in the body and is associated
with regulating pain sensation.
At Artelo Biosciences—a clinical-stage company using
cutting-edge science to improve patient care, drug
development based upon targeting the ECS is showing
Artelo’s drug
candidate, ART26.12
has the poten al to
stand out in the market
due to its poten al
therapeu c value in
preven ng and
trea ng
chemotherapy-induced
peripheral neuropathy
(CIPN), a common and
o en painfully
debilita ng
complica on of cancer
therapies.
Most Promising Pain Management Solu on Providers in 2023
Using Cu ng-Edge Science with Lipid-Signaling
Modula on to Improve Trea ng People with Cancer
promise. The company applies leading-edge scientific,
regulatory and commercial disciplines to develop
innovative therapies, with a particular focus on the needs of
the cancer patient. Realizing the merit of targeting the ECS,
Artelo is on a mission to alter the course of treatment for
those diagnosed with cancer and other serious conditions.
Spearheading Artelo with innovation, conviction and
leadership is the company’s President and Chief Executive
Officer—Gregory D. Gorgas. Committed to improving the
lives of the millions of patients worldwide with cancer
diagnosis, he recruited a team of like-minded researchers,
clinical professionals and business executives in San Diego
and abroad to create Artelo.
Acknowledging such progress at Artelo, we crossed paths
with Gregory Gorgas to learn more about the company and
its mission to meaningfully impact cancer care.
Let’s dive in to know more!
Artelo Biosciences—At a Glance!
Artelo is a story of empathy, innovation and scientific
revolution. Being enriched with the vision and operational
experience of its CEO—Gregory Gorgas, the company aims
to transform the care of a large number of people suffering
through multiple diseases and conditions, including cancer,
pain, anorexia, anxiety, neuropathy, and inflammation with
the help of its novel product candidates in development
designated as ART27.13, ART26.12, ART12.11. Aware of
the tremendous promise of targeting the ECS with lipid-
modifying drugs to treat cancer, pain and central nervous
system (CNS)-related conditions, Artelo initiated its quest
for innovative research early in 2017. By the end of that
year, the company had acquired rights to multiple
technologies and filed a patent on its own invention. In sum,
Artelo’s portfolio represents the broadest spectrum in the
pharmaceutical industry of methods targeting the ECS for
the improvement of health.
In early 2023, Artelo expects to start enrolling patients in
the Phase 2 stage of the Cancer Appetite Recovery Study
(CAReS) with its lead clinical program, ART27.13. Cancer
anorexia (loss of appetite or aversion to food) affects over
60% of people with a cancer diagnosis and is a leading
cause of death for cancer patients. ART27.13 was designed
to arrest the anorexia and resulting weight loss experienced
by the majority of cancer patients. Like the other programs
at Artelo, ART27.13 targets the receptors of the ECS. It
leverages a known effect on hunger without the undesired
CNS effects of cannabis. And the company is well-funded
to complete the CAReS trial as its last reported cash was
nearly $20 million.
Another complication of cancer is pain secondary to the
toxic effects of certain cancer chemotherapies. A key
initiative of Artelo is to bring its second drug candidate into
the clinic within the next 18 months. In multiple preclinical
animal studies, ART26.12 has shown remarkable promise in
treating painful neuropathies associated with chemotherapy.
Artelo’s researchers showed that ART26.12 was able to not
only successfully treat the pain, but also prevent the
neuropathic pain from even starting. Currently, there are no
FDA-approved treatments for chemotherapy-induced
peripheral neuropathy (CIPN). Artelo is on a mission to
change that.
Transforming Pain Management
ART26.12 is a new chemical entity. Because ART26.12 is
at the forefront of Artelo’s innovation, we asked Mr. Gorgas
to elaborate on the science and strategy with this novel
compound. He explained that ART26.12 is a selective fatty
acid binding protein 5 (FABP5) inhibitor. It inhibits a
pathway that can raise endogenous levels of
endocannabinoids, the body’s self-made cannabinoids.
ART26.12 has the potential to stand out as a treatment due
to its therapeutic value in preventing and treating CIPN, a
common and often painfully debilitating complication of
cancer therapies that often results in a reduction or
interruption of cancer treatment. CIPN is frequently so
painful that patients cannot progress on their anti-cancer
therapy.
In preclinical models, inhibition of FABP5 using ART26.12
has shown activity in analgesia, reversing the effects of
CIPN, a condition for which there are currently no
approved treatments. Current pain management medications
typically have significant side effects and/or addictive
properties. To date, FABP5 inhibition has shown little to
none of these effects while exhibiting good analgesic
properties.
In addition to pain, inhibiting FABP5 may be useful in other
areas of unmet need. Of recent note, landmark research in
anxiety with another one of Artelo’s FABP5 inhibitors was
selected as one of the top 50 (out of 12,000 research studies
submitted) at the Society of Neuroscience annual meeting
in November 2022. The preclinical results indicated that a
novel FABP5 inhibitor from Artelo’s extensive library of
FABP inhibitors significantly reduced anxiety behaviors
without the abuse potential or cognition blunting of other
treatments for anxiety disorders. There, it was concluded
that modulation of the FABP5 system might serve as a
promising target for the development of novel anxiolytics.
Key Development Programs
Artelo’s full-spectrum approach to modulating the ECS
with lipid-modifying approaches include:.
Ÿ ART27.13, a cannabinoid (CB and CB ) receptor
1 2
agonist, being investigated in the CAReS trial, currently
enrolling patients with cancer anorexia.
Ÿ ART26.12, a fatty acid binding protein 5 inhibitor, with
regulatory-enabling studies well underway aiming to
have the program in the clinic for chemotherapy induced
peripheral neuropathy within 18 months. A first for a
FABP5 inhibitor.
Ÿ ART12.11, a patented cocrystal composition of
cannabidiol (CBD), in preclinical development for
anxiety-related disorders including post-traumatic
syndrome disorder (PTSD), as well as other potential
indications.
If approved by the FDA,
ART27.13 in cancer
anorexia and ART26.12
in chemotherapy-
induced peripheral
neuropathy would be
first-in-class
treatments for people
that have no currently
approved treatment
op ons.
If approved by the FDA, ART27.13 in cancer anorexia and
ART26.12 in chemotherapy-induced peripheral neuropathy
would be first-in-class treatments for people that have no
currently approved treatment options. Artelo also believes
its CBD cocrystal has the potential to be a best-in-class
drug.
Wholistic Thinking-Treating the Whole Person
While several of Artelo’s programs may ultimately be
useful as anti-cancer agents directly, Mr. Gorgas says the
mission of Artelo today is to treat the whole person with
cancer. While there have been many advancements in the
treatment of tumors over the past two decades, cancer pain
and cancer anorexia are still without FDA-approved
treatments. Mr. Gorgas lamented that treatment of cancer
anorexia has not advanced since he started his career in the
pharmaceutical industry nearly 40 years ago, and the team
at Artelo aims to change that. Using a mechanism-based
approach modulating the ECS holds therapeutic promise
that may have eluded research to date.
Artelo’s priorties for 2023 are 1.) the rapid accrual in the
CAReS Phase 2 with an expansion of clinical sites in
United Kingdom and Europe, 2.) gaining alignment with
the FDA on the pathway and research to bring ART26.12
Current pain
management medica ons
typically have significant
side effects and/or
addic ve proper es. But
to-date, Artelo’s FABP
inhibi on has shown
li le-to-none of these
effects while exhibi ng
good analgesic
proper es.
into the clinic for CIPN (a first for a FABP5 inhibitor), and
3.) advance and expand the understaning of differentiating
properties of its patented CBD cocrystal.
Transformative Leadership—The Intersection of
Experience and Innovation
Mr. Gorgas brings almost four decades experience to his
role in leading Artelo. Before founding Artelo, he served as
Senior Vice President, Commercial and Corporate Officer at
Mast Therapeutics, a publicly-held biotechnology company.
There, he had commercial leadership accountability and
business development responsibilities for the hematology,
oncology and cardiovascular franchises. Prior to that, he
worked at Biogen, a publicly-held biotechnology company,
as Senior Director, Global Marketing, with responsibility
for the strategic vision and operational commercialization
of the company’s worldwide cancer business.
Furthering his commitment to bring healing to people living
with cancer through innovative therapeutics, Mr. Gorgas
became convinced that targeting the body’s
endocannabinoid system with lipid-signaling drugs could
lead to new solutions to old problems. This led Mr. Gorgas
to establish Artleo Biosciences. Modulating the ECS with
federally-compliant cannabinoid-based drug research has
some added complexity and challenges, but the
transformative potential of the programs at Artelo makes it
worth the effort. And Artelo has a competitive advantage of
having successfully navigated complex regulations to
advance its programs across the globe.
Mr. Gorgas envisions benefiting millions of patients
worldwide through the product development at Artelo
Biosciences. The company seeks to attain this vision
through the application of innovative, next-generation
science to real-world challenges for people living with
cancer. Currently, alongside the business potential, Mr.
Gorgas and the team at Artelo derive their motivation to
solve pharmaceutical challenges that have eluded the
industry for decades.
Words of Wisdom
Years ago, Mr. Gorgas read Peter Medawar’s “Advice to a
Young Scientist,” who wrote, “In choosing topics for
research...to enlist in, a young scientist must beware of
following fashion.” Mr. Gorgas found it to be an essential
suggestion.
Following fashion in science or on Wall Street often leads
to dead ends. “When we started Artelo in 2017, federally-
compliant research into the endocannabinoid system was
very new and few dared to pursue the path, but that didn’t
dissuade us. We were convinced that lipid-modulating drugs
would ultimately prove their value in treating serious
medical conditions like cancer pain and anorexia,” says Mr.
Gorgas. “Decades of commitment and smart science
pursued by pioneer researchers in the ECS like Artelo’s
Chief Scientific Officer, Andy Yates, Ph.D., and Professor
Saoirse O’Sullivan, Ph.D., now Artelo’s Vice President of
Translational Research are beginning to pay dividends. We
are excited to be a leading company with this innovation,
and through our efforts we hope people with cancer will
live better in the decades to come than in decades past.”
Artelo Biosciences is traded on the Nasdaq Capital Markets
exchange (Nasdaq: ARTL) and has analyst coverage with
Ladenburg Thalmann & Co. Inc., H.C. Wainwright & Co.,
and Maxim Group.
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Marko Höynälä
CEO and Founder
Kipuwex
Kipuwex Ltd.
Revolutionizing the Telehealth Industry with
a Patient-Centric Approach
Patients who face communication adversities, such as
young children, people with mental illnesses, and
critically ill patients, have difficulty being assessed
for pain. Premature infants whose central nervous systems
have not yet formed and may experience disastrous effects
require specific attention when it comes to pain treatment.
Marko Höynälä is the CEO and Founder of Kipuwex, a
company that develops a small wireless IoT device that
continuously records a patient's physiological parameters
digitally, converts those parameters into pain data using an
algorithm, and provides accurate measurements for both
healthcare professionals and at-home users.
Marko is a globally well-known inventor from Oulu,
Finland, with global experience in multiple technology
fronts, including the IoT (Internet of Things), IoMT
(Internet of Medical Things), AI (Artificial Intelligence),
Remote Patient Monitoring (RPM), and telehealth
industries.
Here are the interview specifics that shed light on the
pressing need to address chronic pain assessment and how
Marko Höynälä is overcoming this obstacle with Kipuwex.
Kindly brief us about Kipuwex and its inception story.
Chronic pain is a deeply personal issue to me, as my father
suffered from cancer. I saw how destructive chronic pain
can be. He couldn’t handle the pain and committed
suicide. Chronic pain is one of the largest
medical burdens worldwide; we can’t even
measure it consistently, so how can we treat
it properly?
Pain is often underdiagnosed or
overtreated, both of which have
long-term impacts on the lives of those it
affects. It was the year 2015 when I came across the local
Northern Ostrobothnia Hospital District’s innovation
competition, in which four major global problems were
faced by healthcare professionals.
One of the difficulties was objectively measuring the
children's pain. I won the competition, and that was the start
of the Kipuwex company. It was highly important that
winning the hospital district’s innovation competition meant
getting to work closely with healthcare professionals.
Today, we have extended our collaborations with leading
medical institutions and hospitals within Europe and Asia.
At first, we started to develop an automatic and objective
medical device for pain measurement, but during the
journey, we changed our strategy.
Kipuwex device will be launched in the healthcare market
as a comprehensive remote monitoring device. In the
second phase, we will integrate a pain measurement feature.
What are the core values of Kipuwex, and how are you
driving Kipuwex to achieve its mission and vision
statement?
I have over 20 years of experience in software
development, so it has been very logical that our core
competencies are software, developing cloud services,
algorithms, applications, and all the other IoT (Internet of
Things) and IoMT (Internet of Medical Things)
technologies.
With Kipuwex, we want to tackle three major healthcare
problems. rising costs of healthcare, e.g., in the USA, 20%
of GDP goes to healthcare. There's a lack of access to
affordable healthcare; at least half of the world’s 8 billion
people still do not have access to essential health services.
Chronic pain is a major global issue, affecting 20% of
Most Promising Pain Management Solu on Providers in 2023
February 2023
17|www.insightscare.com
adults worldwide and costing $560-635 billion in the
United States alone each year.
"Kipuwex’s mission is to combat healthcare inequality and
help millions of people."
"Kipuwex’s vision is to become a world-leading company in
the pain management domain."
Enlighten our readers about the key products and
offerings of Kipuwex and highlight any service that is its
USP.
Kipuwex is a small, wireless IoMT device that measures 12
different physiological parameters, including pain. The
device is attached to the patient’s chest with a disposable
ECG sticker. We measure more physiological parameters
than any other similar device on the market. We have
developed Kipuwex so that it is affordable for developing
countries as well.
Currently, we are developing for home users the first
complete health report in the world. It's a consumer-centric
digital health ecosystem for remote patient monitoring in
cooperation with a unique global partnership. Also, there
are well-being algorithms for preventive care and
personalized heart and emotional well-being monitoring.
In your opinion, what are the current challenges in the
pain management industry? How are you infusing your
leadership skills and expertise over the years to create a
flourishing industry with opportunities and growth?
The medical device business is very challenging. It’s a very
long process to develop a new medical device and to launch
it. The road to a successful launch can be filled with product
development risks. Of course, it involves numerous legal
and economic considerations, so we need to think and
Kipuwex’s advantage and
competitiveness are based on the
fact that the company has
integrated so many sensors into
such a small IoMT device.
February 2023
18|www.insightscare.com
apply. Companies must comply with regulations, which can
be time- and money-consuming.
The biggest challenge is how to make funding last through
product development and to get sufficient funding to
finalize the product development. The global pandemic was
a huge challenge and postponed clinical trials. Product
testing should begin early in the development process and
continue throughout. The war in Ukraine has caused a lack
of components.
The present research is serving as the baseline for better
future strategies to improve global health initiatives, as our
ecosystem is very scalable and can be integrated as well.
We are getting continuous questions, is it possible for third
parties to integrate our platform in their own use cases?
Opportunities are quite endless when thinking of growth
potential.
What are the latest technological advancements adopted
by Kipuwex to deliver the best pain management
services in the industry? How is it impacting the
demographic concerned?
Kipuwex product is protected by patents and know-how.
Our advantage and competitiveness are based on the fact
that we have integrated so many sensors into such a small
IoMT device. For the pain measurement feature, we are
granted two patents, which are essential and extremely
important to stimulate the innovation, development and
commercialization of Kipuwex.
As an experienced leader, what would be your advice for
aspiring entrepreneurs and enthusiasts who wish to
venture into the MedTech sector?
Being an entrepreneur is difficult, especially in the
MedTech industry, which is difficult in many ways. It also
needs years of hard work to go to market. You must have a
strong vision, mission and problem-solving abilities that are
more than just business to you.
What are the future goals of Kipuwex, and How do you
envision scaling up its operations and reach in 2023 and
beyond?
Kipuwex's mission is to provide remote monitoring devices
throughout the world. Our vision is to become a world-
leading company in the pain management domain.
The Words that Signify a Bequest
“Billions of people still do not have access to essential
health services, and at the same time, health care costs are
unsustainable across the world. Next generation sensor
technologies, in combination with smart algorithms, bring
unlimited opportunities to ensure accessible and affordable
healthcare solutions. Kipuwex remote monitoring device is
well positioned to play an important role in revolutionizing
the integration of quality healthcare outside hospitals.”
Ÿ Prof. Dr. Niclas Adler, CEO and Founder of Adler
Industries. CEO and Founder of Synthesis Group,
iHealth Solutions, and iPower Group. Stockholm,
Sweden
“Kipuwex is one of the state-of-the-art devices for pain
management, which is the need of the hour in this era of
digitalization and can revolutionize pain management in
certain sectors of the population. It also has the promise of
being utilized as a unique remote vital parameter
monitoring device such as in emergency kits, and such
devices have now become a necessity.”
Ÿ Prof. Dr. MCh. B J Rajes, Consultant Neurosurgeon at
Yashoda Hospitals, Hyderabad, Telangana, India
February 2023
19|www.insightscare.com
Management
Explanation to
ince pain is a subjective experience, each person
Sexperiences it differently. Physical or psychological
pain can affect a person's mental and emotional well-
being. Torment the board includes various strategies and
techniques to assist people with dealing with their
aggravation.
Psychological explanations for pain management can also
be beneficial, in addition to physical treatments like therapy
and medication.
Let's examine the psychological basis for pain management
and its benefits!
Understanding the Psychological Basis for Pain
Management
Psychological pain management entails the application of a
variety of strategies to assist individuals in coping with
pain. According to the psychological explanation of pain
management, pain is both a physical and a psychological
experience. This indicates that a person's thoughts, feelings
and actions can impact pain.
According to the psychological explanation of pain
management, these psychological factors can be addressed
to manage pain. For instance, a person's perception of pain
can be influenced by their beliefs.
A person's pain may become more severe if they believe it
is intolerable and unmanageable. However, people may feel
more in control of their pain if they think it can be
managed.
Reconceptualizing Pain
Fear of pain is normal because it is a natural learning tool
and a horrible feeling. Patients who experience persistent
pain tend to develop a fear of pain and, as a result, stop
doing activities that make them feel pain, such as moving
their bodies, which is typical of osteoarthritis.
Through education, rethinking pain, cognitive behavioral
therapy (CBT), and the other methods on this page, the
cycle of chronic pain and disability can be broken. This fear
of pain can become a cycle that never ends.
February 2023
20|www.insightscare.com
Cognitive Behavioural Therapy (CBT)
One approach for psychological pain management is
cognitive behavioral therapy (CBT). The goal of cognitive
behavioral therapy is to assist people in recognizing and
altering negative thoughts and actions that cause pain. CBT,
for instance, can help people challenge the belief that they
are weak or damaged due to pain and develop more positive
and realistic views.
Mindfulness
Care is one more method utilized in the mental torment of
the board. Being aware of the present moment and
accepting it without judging it is mindfulness. Stress and
anxiety can be reduced through mindfulness, which can
assist individuals in pain management. Stress and
nervousness can exacerbate the aggravation, so diminishing
these feelings can assist with overseeing torment.
Massage
Massage treatment, like unwinding, is commonly utilized as
an assistant to conventional treatment modalities. It is
generally used close by and contrasted with unwinding and
other mental medicines, so remembering was considered
advantageous.
Since its inception in the 2nd century BC, massage therapy
has developed numerous techniques and subfields,
including Swedish massage, Shiatsu, Rolfing, reflexology,
and craniosacral therapy.
In one of the studies, massage was more effective than a
placebo treatment. In the remaining seven studies, there was
no significant difference between exercises and corsets, and
the massage was superior to relaxation, acupuncture and
education.
Relaxation Therapy
Relaxation can take a variety of forms, including spiritual
or non-spiritual meditation, progressive relaxation or
muscular contraction and relaxation, and even imagery. It is
generally used in conjunction with other treatment
modalities.
Typically, relaxation is considered an "Alternative"
treatment that must be used in conjunction with
conventional medical care rather than on its own. This
could be because the treatment's theoretical foundations
haven't been proven or there isn't enough high-quality
evidence to support it.
Restoring normal equilibrium within the body's systems is
one way that relaxation therapy may be effective. This can
be accomplished by reducing the effects of stress on the
body. The body's most fundamental response to stress is a
"fight or flight" response that triggers several biochemical
changes.
Benefits of Psychological Explanation to Pain
Management
The psychological explanation for pain management has
numerous advantages over spinal manipulation and
transcutaneous electrical nerve stimulation in terms of
effectiveness.
First, it can give people a sense of control over their pain.
People may feel more empowered to manage their pain
when they realize their thoughts and actions can affect it.
Self-confidence and self-esteem may rise as a result.
Second, these methods may lessen the requirement for
medication. Medication can potentially alleviate pain, but it
can also have adverse effects and become addictive.
Psychological techniques can be used to manage pain
independently or with medication.
Thirdly, psychological pain management has the potential
to enhance a person's quality of life. Torment can
essentially affect an individual's psychological and
profound prosperity. People can improve their mood,
reduce stress and anxiety, and participate in more social
activities by controlling pain.
In sum-up,
The psychological explanation of pain management
suggests that pain is a psychological and a physical
experience. People can better manage their pain by
addressing the psychological factors that cause it.
Psychological methods for managing pain, such as
cognitive behavioral therapy (CBT) and mindfulness, can
give people a sense of control over their pain, lessen the
need for medication, and raise their overall quality of life.
Talking to a medical professional about psychological pain
management methods might be helpful if you are having
pain.
- Shreyasi Shelke
February 2023
22|www.insightscare.com
Nen Evidence
Based Solution S.L.U.
(nen) A Pain Management Solu on, Designed for Kids Figh ng Cancer
ediatric cancer is a global problem that children and
Ptheir families struggle with. Almost 500,00 children
will be diagnosed with cancer this year and nearly
all of the will experience pain during their first year. Pain
management in children remains an enormous unmet
medical need that is not currently served by current
practices. Because of the relative homogeneity of pain in
cancer (procedural pain and pain from cancer itself), Nen
Evidence-Based Solution S.L.U. (nen), a clinical-stage
company is developing evidence-based digital therapeutics
to help kids fighting cancer, their families and their doctors
manage pain.
Pain management is addressed through play, by leveraging
gamification of cognitive behavioral therapy to modulate
pain and improve a child's overall well-being and outcomes.
Through validated outcome measures, both families and
physicians can provide insightful and tailored pain
management support to children who currently lack
alternative means to express their needs.
With the support of Francesca Domenech Wuttke
(Founder & CEO) and Xènia Riasol Cercos (COO), nen
is a mission-driven profit-for-purpose company to
democratize pain management at scale to all kids who are in
pain, wherever they are.
Let's dive in to learn about Nen's operations in meeting its
objective.
What inspired you to establish Nen Health?
When I started thinking about my next steps, I wanted to do
something with a more direct patient impact. I put my
consulting hat back on and did a scan of the whole of the
digital health market to identify gaps. I wanted to know
what those gaps are and if can they be filled with a digital
solution or service but more specifically with a digital
therapeutic.
I feel strongly that DTx is the fourth wave of medicine:
small molecules, biologics, cell and gene therapy, and now
digital therapeutics. I was surprised by the dearth of activity
in the pediatric digital health space and had worked on a
DTx for pain in adults and saw how readily the CBT
modules could be translated to a digital platform and
thought why not apply that to kids that were the genesis of
nen.
What are the core values of the company? How are you
driving the company to achieve its mission and vision
statement?
nen is focused on developing kid-centric care designed for
their minds- because kids matter and we are committed to
kids.
nen offers a novel mission-driven
approach to address pain
management through play leveraging
gamifica on approaches and cogni ve
behavioral therapy (CBT) to modulate
pain and improve their overall
well-being and outcomes. We are
crea ng an app-based pla orm
for smartphones/tablets. The CBT
modules will be age- appropriate
and designed for children to be
engaging and enjoyable for them.
Most Promising Pain Management Solu on Providers in 2023
February 2023
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Francesca Wu ke is the CEO and
Founder of nen-bringing evidence-
based Digital Therapeu cs (DTx)pain
solu ons to kids with cancer. Dr.
Wu ke brings broad drug development
and healthcare exper se in both the
US and Europe, with nearly 30 years of
clinical, commercial, strategic and
transac onal experience. She has
worked with diverse organiza ons
including start-ups, consul ng, large
and specialty pharma as well as
academia. Formerly, she was the Chief
Digital Officer of Almirall where she
created the Almirall Digital Garden to
accelerate and incubate digital health
startups. Dr. Wu ke worked at Novar s
where she was responsible for two Cell
and Gene therapy opportuni es that
were successfully brought into the
organiza on as well as managing the
strategy and commercializa on for the
exis ng por olio of cell therapy assets.
Dr. Wu ke holds a Ph.D. in
Pharmacology from Weill Cornell
Graduate School of Medical Sciences
and a BA from Cornell University
College of Arts and Sciences.
About the Founder
Francesca Domenech
Wu ke
Founder & CEO
Nen Evidence Based
Solu ons, S.L.U. (nen)
About the Founder
February 2023
25|www.insightscare.com
About the COO
Xènia Riasol is the Chief Opera ng
Officer of nen. She is experienced in
launching digital therapeu cs across
Europe and in crea ng and deploying
customer-centric digital solu ons
globally. Xenia is a digital innova on
and strategy expert with a focus on
commercializa on models and global
solu on deployment. She has extensive
experience in Pharma, where she was
bringing digital innova ve solu ons to
pa ents and managing strategic digital
marke ng campaigns globally. As Chief
Opera ng Officer, Xenia is responsible
for leading the product planning and
evolu on, marke ng strategies, and for
the everyday running of the business,
turning industry knowledge into
ac onable business channels and
revenue streams for the company. She
works with investors, partners, advisors
and pa ents to manage the strategy
and path forward for nen.
Xènia Riasol Cercos
COO
Nen Evidence Based
Solu ons, S.L.U. (nen)
About the COO
February 2023
26|www.insightscare.com
How big is the addressable market?
Pain management in children remains an enormous unmet
medical need that is not currently served by current
practices. To date, no current solutions exist to moderate
pain designed specifically for kids. The current modalities
including pain assessment and then treatment scales are
incredibly subjective and not appropriately modified for use
in children, particularly in small children.
nen offers a novel mission-driven approach to address pain
management through play leveraging gamification
approaches and cognitive behavioral therapy (CBT) to
modulate pain and improve their overall well-being and
outcomes. We are creating an app-based platform for
smartphones/tablets. The CBT modules will be age-
appropriate and designed for children to be engaging and
enjoyable for them.
Who are your target customers?
nen's first indication is for school-aged children from 7-12
years old, as they have more developed
neurodevelopmental skills where CBT is considered a
clinically validated and well-established therapy. After we
have established a solid and tested the regular nen solution
(with proven efficacy and learnings) nen will continue to
develop the platform to serve patients from 2-6 as this age
group remains a huge unmet need as very few digital
solutions for pain management are addressed specifically to
them and yet they too suffer from pain (both physically and
psychologically). We will then expand to adolescents.
As an experienced leader, what advice would you like to
give to aspiring entrepreneurs and enthusiasts who wish
to venture into the competitive industry that you are
serving?
Patience and resilience. There will be a lot of no's along
your path but if you stay true to your mission and vision
you can achieve great things.
What are the future goals of the company? How does it
envision scaling up its operations and reach in 2023 and
beyond?
We have designed our business model with flex so that we
are not reliant on the ever-changing regulatory landscape.
Ÿ B2C: The first iteration is a pediatric oncology patient
support tool, designed for GDPR/HIPAA and ISO
compliance at inception and with parallel development
in US and Europe in English (UK and American)
Spanish, French, Italian, German, and Dutch. This tool
will initially be targeted to parents so we can beta-test
the outcomes. We expect to launch this product in late
2023 and then after it is clinically validated, we will
offer a premium product (identical to the PDT) with
robust medical claims at a higher price point.
Ÿ B2B: Next, we will continue to forge research
collaborations with academic institutions to generate
clinical evidence while gaining champions.
Ÿ Rx: Standalone Prescription Digital Therapeutic (PDT.)
Once registered as SaMD, or under DiGA or similar
laws, we will seek reimbursement as a standalone PDT
across various payor systems, models and geographies.
February 2023
27|www.insightscare.com
Rescape
Innovation Limited
Reducing Pain and Anxiety Through Virtual Reality
n several healthcare specialisms, doctors and
Icaregivers are often puzzled about the best way to help
their patients cope with pain and anxiety, two dominant
concerns of their suffering.
This is because patients during treatments are usually
focused on their pain, which increases their perception of
pain. Not only do they feel anxious about it, but they also
end up feeling helpless and out of control over the situation.
In response to such a pain dilemma, distraction has proven
to be an effective coping tool to help patients reduce their
pain and anxiety. It encourages them to focus on a specific
task (i.e., a pleasurable activity, puzzles, games, etc.) and
attain a sense of control.
With the proven effectiveness of distraction as a tool,
Rescape Innovation Limited provides a unique solution to
ease the lives of patients. Its Class-one innovative medical
device, DR.VR™, enables quick, easy and monitorable
deployment of virtual reality therapy to improve the
patients' reported level of pain and has been effective
compared to opioid analgesics.
In an interview with Insights Care, Matt Wordley, the
CEO, talks about the role of virtual reality in clinical
practice, along with Rescape's contribution in delivering it
to improve the experience of patients' pain and anxiety.
Below are the highlights of the interview.
Kindly brief us about the company and its inception
story.
Rescape Innovation was born when I attended a TED talk
by a palliative care consultant, Professor Mark Taubert,
who explained the difficulties of communicating with his
patient cohort. There I developed an interest in immersive
technology through other business interests and felt that I
would be able to use the technology to address some of the
issues that had been raised in the TED talk. I spoke to
Professor Taubert immediately after the talk and the journey
of Rescape began!
Please tell us about yourself and your professional
journey so far.
I am one of the original creators of The Orchard Media
Events Group. I have been instrumental in building it into a
world-class agency, TV production company and Live
Music promoter. As an earlier adopter and advocator of VR
technology within Orchard, Rescape was spun out to unlock
the healthcare opportunity, and I took the reigns as CEO.
What are the core values of the company? How are you
driving the company to achieve its mission and vision
statement?
Very early on we saw the impact that Virtual Reality
Therapies could have on patients' pain and anxiety. This
was anecdotal but very clear and we started to evidence this
impact. We committed then to helping as many patients as
possible have access to VR treatments. This core value is an
important principle we try to benchmark everything we do
against. VR should be available to all and we're determined
to deliver against this promise.
Could you please list the key products and offerings of
the company? Also, please put light on any service that
is the company's USP.
DR.VR is a Class 1 medical device that is being utilized by
hospitals, care homes and hospices to alleviate anxiety and
reduce the perception of pain for patients and family
members of patients. Another product is Frontline, which
has been designed to support the well-being of NHS staff
and has also been adopted by several universities to support
staff and students.
February 2023
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The priority for our development team is on ensuring that
user-centric design is at the heart of all we do as that gives
us the ability to deploy simple solutions at scale, ensuring
that the benefits of immersive therapeutics are enjoyed by
as wide an audience as possible.
In your opinion, what are the current challenges in the
pain management industry? How are you infusing your
leadership skills and expertise over the years to create a
flourishing industry with opportunities and growth?
We are at the beginning of a fundamental shift in medicine
adopting a more holistic view of the patient. Historically
mental and physical health have been treated independently
as if they were unconnected and this divide is very slowly
being bridged.
Pain is a complex, multifaceted biopsychosocial problem
that requires a solution that addresses multiple elements
concurrently and chronic pain clinics are now starting to
use a multidisciplinary approach to treatment involving
psychiatrists, psychologists, anesthetists, physiotherapists,
nurses and occasionally social workers.
Our job is to build the evidence base to prove that
Immersive Therapeutics should be an important component
in treating pain by addressing mental and physical health at
the same time and become a mainstay in the suite of
treatment options to help patients.
What are the latest technological advancements adopted
by your company to deliver the best pain management
services in the industry? How is it impacting the
demographic concerned?
We call ourselves pragmatic technologists; the real world is
never easy and always messy. We are proud that our DR.VR
solution is user-friendly for both patients and clinicians. We
have a phrase we use when developing content "Don't
create things to watch but space to inhabit." This is a key
remit for successful VR pain therapies; the deeper level of
immersion we create, the more success we can create.
As an experienced leader, what advice would you like to
give to aspiring entrepreneurs and enthusiasts who wish
to venture into the competitive industry that you are
serving?
Understand the complete system you are trying to work
within. Sadly it's not good enough to just create a Virtually
Reality that has therapeutic benefits. You have to deliver a
simple and deployable solution. Read up, research and
Very early on we saw the
impact that Virtual Reality Therapies
could have on patients' pain and anxiety.
This was anecdotal but very clear and
we started to evidence this impact.
Based on the Virtual Reality principle,
our innovative product, DR.VR, is a Class
1 medical device that is being utilized by
hospitals, care homes and hospices to
alleviate anxiety and reduce the perception
of pain for patients and family members
of patients.
Matt Wordley
CEO
Rescape innovation Limited
Most Promising Pain Management Solu on Providers in 2023
February 2023
29|www.insightscare.com
embrace user-centric design practice and you will develop
much better solutions. At times that means embracing the
elephant in the room and tackling the hard things head-on.
There are so many examples where we have done this from
a lack of NHS wifi to infection control protocols or making
sure our content reduces motion sickness.
What are the future goals of the company? How does it
envision scaling up its operations and reach in 2022 and
beyond?
The opportunities for the use of VR in healthcare are in
their infancy. We have several exciting research projects
that will be concluding in 2023 and we're excited about the
opportunities this will open. Referencing our core values,
we want to give access to as many people as possible and in
'23 we will be launching a pain solution that can be
accessed from home. This in part, is driven by a growing
number of patients that have asked if they can use the
solution at home.
Give us a few testimonials from your clients or
customers and awards or recognition that accurately
highlight your company's position in the market.
"VR intervention demonstrated a significant reduction in
patient and parental anxiety both pre-operatively and in the
fracture clinic."
"The improvement in patients' reported pain after VR,
particularly for those patients with higher pain scores (3.41
points out of 10), was remarkable and is comparable with
opioid analgesics."
Dr. Ceri Lynch, published in ICU Management.
“91% [of patients] reported lower anxiety levels after using
the headset."
Potter, T., Curran, Jr, 2021 Using DR.VR® in a Burns
Unit
"I have been a nurse for over 25 years, working mainly in
cancer and palliative care, and this was probably one of the
most amazing, moving and beautiful experiences I have
witnessed."
Gillian, Lead Nurse, Marie Curie Hospice, Newcastle
"The mindfulness areas teaching me how to calm and
breathe were amazing for my worry and anxiety."
PID 105, FRONTLINE RELIEF: A brief evaluation
"I think it's really good for taking you out of a stressful
environment and calming you down. I like that there were
lots of different options for what to do because people have
very different preferences."
University Hospital Bristol & Weston Evaluation
Documentation
February 2023
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February 2023
32|www.insightscare.com
Manage
Pain
Effective Techniques
Used to
How to Overcome?
ain is an experience that affects people of all ages,
Praces and genders. It is a universal feeling. Several
things, like injuries, illnesses and long-term
conditions, can bring it on. Because it can increase a
patient's capacity for daily activities and improve their
quality of life, pain management is an essential part of
healthcare.
The two most common types of pain are acute and chronic.
Acute pain is typically brought on by a sudden occurrence
such as surgery, bone fractures, infections, cuts and
lacerations, falls, and burns. A doctor usually treats acute
pain immediately following the triggering event. The pain
typically subsides as the injury or condition heals, generally
disappearing within six months.
Let's have a look at techniques to manage pain!
Medication
Prescriptions are, much of the time, the primary line of
treatment for torment. They fall into one of two categories:
opioid and non-opioid drugs.
Over-the-counter pain relievers like acetaminophen and
ibuprofen and prescription medications like non-steroidal
anti-inflammatory drugs (NSAIDs) are examples of non-
opioid medications. Drugs like morphine, oxycodone and
fentanyl are some examples of opioids.
Physical Therapy
Another effective method for managing pain is physical
therapy. It involves stretching, exercises, and other physical
methods to increase mobility and decrease pain. Patients
with musculoskeletal conditions like back pain, arthritis and
fibromyalgia may benefit most from physical therapy.
Actual advisors can work with patients to foster
individualized treatment designs that focus on the
underlying driver of their aggravation. These plans may
include manual therapy, therapeutic exercise, and other heat
or cold therapy treatments.
February 2023
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Psychological interventions
These interventions, like mindfulness meditation and
cognitive-behavioral therapy (CBT), can also be helpful in
pain management. Positive thought patterns that can
exacerbate pain are identified and changed in CBT. Care
reflection includes zeroing in on the current second and
tolerating actual sensations without judgment.
Patients may benefit from these methods in developing
coping mechanisms that lessen the impact of pain on their
daily lives. They can also improve mood and lower stress
levels, which can help break the cycle of chronic pain.
Chronic Pain
Finding the most effective pain relief methods for one's
condition can take some time due to the complexity of
chronic pain. Yoga, drug treatments, and hot and cold
therapy are just a few options available.
An injury or a medical condition can lead to chronic pain. If
pain persists for more than three months, or if it continues
beyond the standard healing period for the underlying
condition or injury, it is considered chronic. It can impact
everything from a person's work and social life to their
sleep and mental health.
The Centres for Disease Control and Prevention (CDC)
estimated that approximately 20% of adults in the United
States had chronic pain, with 8% experiencing high-impact
chronic pain.
According to the Trusted Source Global Burden of Disease
Study from 2017, chronic pain and related diseases are the
leading causes of disability worldwide. It has a relationship
with various physical and psychological well-being
conditions, including wretchedness, rest issues, social
segregation and abuse of prescription.
Techniques to Overcome Chronic Pain
Hot and cold treatment
Hot and cold treatment is a typical and safe method to
lessen torment. Intensity can assist with loosening up the
muscles and enlarging the veins. It can also help wounds
heal after an accident.
Cold therapy reduces pain-causing inflammation and blood
flow. The skin is frequently treated with an ice pack
wrapped in a towel.
Acupuncture
A practitioner performs acupuncture by inserting fine
needles into the skin at specific points on the body.
The National Centre for Complementary and Integrative,
Health Trusted Source says that there is evidence to suggest
that this method could assist individuals in managing
certain pain conditions. This includes temporary relief from
osteoarthritis and lower back, neck and knee pain.
However, there is little evidence to suggest that it is long-
lastingly effective.
Acupuncture has been suggested to alleviate pain, reduce
inflammation, promote relaxation and lessen muscle
spasms. When performed by trained practitioners with
sterile needles, acupuncture is generally safe.
Mind-Body Practices
Yoga
Yoga uses specific poses that target specific body parts to
relax, strengthen and keep the body flexible.
A report in 2010, into yoga's consequences for ongoing
torment, found that it didn't diminish members' aggravation.
Yet, it assisted them with adapting, and they were more in
charge of what their aggravation meant for their day-to-day
existence.
On the other hand, yoga has been shown to reduce pain in
other studies. It is a safe and easy way to manage pain. You
can try it at home, watching videos online, or in a class with
a teacher.
In conclusion,
Managing pain and chronic pain can be done in several
ways, many of which are accessible and straightforward to
use. Most pain management methods aim to lessen or
enhance a person's capacity to cope with chronic pain.
A professional therapist should be used for pain
management techniques like acupuncture, physical therapy
and yoga to ensure anyone can safely practice them.
- Shreyasi Shelke
February 2023
34|www.insightscare.com
Soovu Labs, Inc.
Relieving Pain Through an Innovative
Heat Delivery Approach
he old wives’ tale of taking out hot water bottles to
Treduce body pain has some truth in it. And science
is taking it seriously. Heat provides comfort to the
body, and can reduce pain at the receptor level with the
right temperature and application. Soovu Labs, Inc. has
used this mechanism at its core for the discovery of new
drug-free pain relief treatments. While it's difficult to use
electric heating pads and hot tubs on the go and steady high
temperatures can damage the skin, the company has solved
these challenges with its Soovu™ Pain Relief System.
Soovu™ is a wearable pain relief device with patented
HeatWave™ technology that pulses waves of heat at
optimal temperatures to the area that hurts, for effective,
targeted pain relief. This device delivers fast and effective
relief, leaving users pain-free and comforted. Following are
the key benefits that set the Soovu™ device apart from
other heat-delivery mechanisms.
Ÿ Relief starts in as little as five minutes.
Ÿ Lasting relief up to 3.5 hours.
Ÿ 61% pain reduction after eight weeks.
Ÿ Wireless and can be used on-the-go.
In an interview with Insights Care, Allan Stephan, the
CEO and Co-founder, talks in-depth about the company's
innovation in treating pain drug-free.
Following are the excerpts from the interview.
Kindly brief us about the company and its inception
story.
Soovu Labs is transforming the treatment of pain by
providing safe, effective alternatives to pills and invasive
procedures. The company was founded by two board-
certified pain specialists who grew increasingly frustrated
watching many patients’ lives compromised by opioid
dependence and other patients demoralized after numerous
procedures failed to meaningfully reduce their pain. After
securing funding from the National Institutes of Health,
they teamed up with Allan Stephan, a seasoned engineer
and product design executive, to develop the Soovu™
wearable thermal neuromodulation system for pain relief.
Please tell us about yourself and your professional
journey so far.
I work on solving complex problems and have a special
appreciation for the different skills and effort required to
unlock puzzles. An engineer by degree, I founded my first
company, Stratos, a multi-discipline product development
firm, in 1987. Stratos' clientele included venture capital
back companies and major organizations like Apple,
Microsoft, Intel, Google, Amazon, Boston Scientific,
Medtronic, and Abbott.
I incubated several emerging companies in wearable
computing, medical devices and life sciences within
Stratos. VoxWare acquired Inroad (wearable computer) in
2000. Sony acquired Micronics (microfluidic diagnostics)
in 2010. Millipore acquired Amnis (imaging flow
cytometry) in 2010. Roche acquired Stratos Genomics
(DNA sequencing) in 2020.
In 2016, I stepped down from Stratos to lead my remaining
incubation to address the world's pain epidemic, Soovu
Labs.
What are the core values of the company? How are you
driving the company to achieve its mission and vision
statement?
Soovu Labs' objective is to help everyone be the best they
can be. I surround myself with incredible people, clear their
paths, and let them roll out solutions.
Most Promising Pain Management Solu on Providers in 2023
February 2023
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Allan Stephan
Co-founder and CEO
Soovu Labs, Inc.
February 2023
37|www.insightscare.com
Unlike typical pain relief
solutions, Soovu delivers relief
within 5 minutes of the first heat
therapy, is drug-free, and can be
used discreetly and safely at work,
home, rest or play. Quick and
e cient pain relief can improve
mobility, mood, sleep and
productivity as well as reduce the
need for pain medication and
pain therapies.
Could you please list the key products and offerings of
the company? Also, please put light on any service that
is the company’s USP.
Soovu Labs’ flagship product is the Soovu™ Pain Relief
System, an FDA-registered class II medical device for the
temporary relief of chronic and musculoskeletal pain and
menstrual discomfort. Soovu is available without
prescription and is currently marketed as a drug-free
workforce pain management solution. Unlike typical pain
relief solutions, Soovu delivers relief within 5 minutes of
the first heat therapy, is drug-free, and can be used
discreetly and safely at work, home, rest or play. Quick and
efficient pain relief can improve mobility, mood, sleep and
productivity as well as reduce the need for pain medication
and pain therapies.
In your opinion, what are the current challenges in the
pain management industry? How are you infusing your
leadership skills and expertise over the years to create a
flourishing industry with opportunities and growth?
The greatest challenge of pain is treating it without creating
even more dangerous outcomes. Whether from addiction to
opioids or death from heart attacks, strokes, and organ
injury from NSAIDs, treating pain is a risk. My career has
been looking at problems from non-traditional angles to see
what others missed. We are advancing knowledge beyond
existing therapies by looking at pain's pivotal role in the
immune system. We see variations of our work in pain
management rolling out for years to come.
What are the latest technological advancements adopted
by your company to deliver the best pain management
services in the industry? How is it impacting the
demographic concerned?
The Soovu™ Pain Relief System targets the TRPV1
receptor, which was the focus of Nobel Prize-winning
research in 2021 on temperature and pressure-sensitive
receptors. Soovu's patented HeatWave™ thermal
neuromodulation technology desensitizes the TRPV1
receptor to block the pain response for several hours. Soovu
delivers relief within minutes, on par or faster than most
medications, and does so without the risk of severe side
effects. Its portable form factor and ability to use on the go
make Soovu an ideal drug-free pain relief solution for
individuals who need relief as they carry on with their lives.
February 2023
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As an experienced leader, what advice would you like to
give to aspiring entrepreneurs and enthusiasts who wish
to venture into the competitive industry that you are
serving?
If you aren't a natural salesperson, get yourself an equal
partner because success is creating something people are
willing to buy, and it takes longer than you'll imagine.
What are the future goals of the company? How does it
envision scaling up its operations and reach in 2023 and
beyond?
Establishing Soovu as the safest and most enjoyable method
of pain reduction will always be our goal. This year, we are
kicking off pilot trials with major corporations to address
the enormous negative impact employees in pain have on
an organization's profitability while demonstrating Soovu's
positive impact on employees’ lives. Soovu will eventually
address clinical pain applications and consumer solutions in
years to come.
Give us a few testimonials from your clients or
customers, and awards or recognition that accurately
highlight your company’s position in the market.
“Soovu helps me get back to active life”
“The first time I used my Soovu I had muscle spasms in my
back, typically I need a chiropractor or massage therapy to
work those out, but when I put Soovu on it helped calm the
muscles down. My Soovu has become a very useful tool for
when I overdo it one way or another to help me get back to
active life.”
- Erik L, Soovu User
Entrepreneur, suffers from arthritis, avid athlete.
“I bring Soovu with me and use it at work”
"Soovu helps me pinpoint the area that is hurting. For me,
it's instant satisfaction. I like that I can stick it on wherever
I want and go on with my day, so I am not stuck on the
couch. I bring the kit with me and use it at work. I let some
of my co-workers borrow my pods and they swear by it, my
wife loves it, it’s a great product.”
- Scott S, Soovu User
Building Engineer, suffers from chronic back pain from
injury.
“For me, relief was pretty much immediate and long-
lasting”
“I recently had a baby and I’ve had a lot of lower back pain
since then. Since I’ve been breastfeeding, I try to minimize
medications for pain and just take an occasional Tylenol, so
to have Soovu as an adjunct therapy for pain has been
incredibly helpful. I’ve used heat in the past to help with
pain, but Soovu is different. You can feel the heat right
away, in a very targeted place where you feel pain. Relief
was pretty much immediate for me and long-lasting."
- Sheena H, Soovu User
Anesthesiologist/Pain Physician, suffers from back pain.
February 2023
39|www.insightscare.com
Most Promising Pain Management Solution Providers in 2023V2 1.pdf
Most Promising Pain Management Solution Providers in 2023V2 1.pdf
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Most Promising Pain Management Solution Providers in 2023V2 1.pdf

  • 1. February Issue : 08 2023 An Insider Psychological Explana on to Pain Management How to Overcome? Effec ve Techniques Used to Manage Pain Artelo Biosciences Using Cu ng-Edge Science with Lipid-Signaling Modula on to Improve Trea ng People with Cancer Most Promising PAIN in 2023 Management SOLUTION Providers Gregory D. Gorgas President, Chief Execu ve Officer Artelo Biosciences
  • 3.
  • 5. ain management is an ever-evolving field, with new Ptreatments and technologies emerging all the time. As the healthcare industry shifts towards a more patient-centered approach, there is a growing need for pain management solutions that are safe, effective and tailored to individual patient needs. One of the emerging trends in pain management is the use of non-pharmacological interventions. With the growing concern over opioid addiction and abuse, non- pharmacological interventions like cognitive-behavioral therapy, acupuncture and physical therapy are becoming increasingly popular. These treatments are effective in managing pain and have fewer side effects than traditional pain medications. Another promising trend is the use of digital health tools to manage pain. The use of mobile apps and wearables to track pain symptoms and medication usage is on the rise. These tools provide patients with real-time data about their pain levels and can help healthcare providers make more informed decisions about treatment options. Personalized medicine is also playing an important role in the future of pain management. With advancements in genomics and molecular biology, healthcare providers can identify genetic variations that influence a patient's response to pain medications. This information can be used to develop personalized treatment plans that are more effective and have fewer side effects. Innovative medical devices and therapies are also transforming pain management. Devices like spinal cord stimulators and peripheral nerve stimulators can provide relief for chronic pain sufferers. Emerging therapies like stem cell treatments and regenerative medicine show great promise in repairing damaged tissue and reducing inflammation. Finally, there is a growing recognition of the importance of interdisciplinary care in pain management. A team-based approach that includes healthcare providers from different specialties, such as pain medicine, physical therapy and psychology, can provide patients with comprehensive care that addresses all aspects of their pain. In Insights Care's latest edition Most Promising Pain Management Solution Providers 2023, we bring to you a comprehensive list of companies that are leading the charge in providing innovative solutions to tackle pain management, a critical issue that affects millions of people worldwide. Hope you have an interesting read! -Pooja Shah The Future of Pain Management: Emerging Trends and Innova ons
  • 6. Artelo Biosciences Using Cu ng-Edge Science with Lipid-Signaling Modula on to Improve Trea ng People with Cancer 08 Ctts Cover Story Ctts
  • 7. Effec ve Techniques Used to Manage Pain How to Overcome? 32 Psychological Explana on to Pain Management An Insider 20 Aicl Kipuwex Ltd. Revolu onizing the Telehealth Industry with a Pa ent-Centric Approach 16 Nen Evidence Based Solution S.L.U. (nen) A Pain Management Solu on, Designed for Kids Figh ng Cancer 24 28 36 Soovu Labs, Inc. Relieving Pain Through an Innova ve Heat Delivery Approach Rescape Innovation Limited Reducing Pain and Anxiety Through Virtual Reality
  • 8. Editor-in-Chief Merry D'souza Senior Editor Anish Miller Managing Editor Pooja Shah Assisting Editors Saloni, Shreyasi Visualiser David King Art & Design Head Mrunalinee Deshmukh Co-designer Paul Belin Art & Picture Editor Sonia Raizada Business Development Manager Amy Jones Marketing Manager John Smith Business Development Executives Sarah Wilson, John Smith, Alex Vincent Sales Executives Kelli, Bill, Anna Technical Head Jacob Smile Assistant Technical Head Prachi Mokashi Technical Consultants David, Robert Digital Marketing Manager Alina Sege Assistant Digital Marketing Manager Renuka Kulkarni SME-SMO Executives Gemson Research Analyst Eric Smith Circulation Manager Tanaji Fartade Copyright © 2023 Insights Success Media and Technology Pvt. Ltd., All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from Insights success. Reprint rights remain solely with Insights Success Media and Technology Pvt. Ltd. Insights Care is powered by Insights Success Media and Technology Pvt. Ltd. February, 2023 sales@insightscare.com Contact Us: Follow us on : www.facebook.com/InsightsCare/ https://twitter.com/Insightscare Insights Success Media Tech LLC 555 Metro Place North, Suite 100, Dublin, OH 43017, United States Phone - 302-319-9947 Email: info@insightscare.com For Subscription: www.insightscare.com Insights Success Media and Technology Pvt. Ltd. Survey No.133/134, Brand Square, Office No. 512, Kunjir Chowk, Pimple Saudagar, Pune, Maharashtra 411027. Phone - India: 7410033802, 74100058552 Email: info@insightscare.com For Subscription: www.insightscare.com We are also available on :
  • 9. Most Promising Pain Management Solution Providers in 2023 Description Company Featuring Person Artelo Biosciences, Inc. Artelobio.com Gregory D. Gorgas CEO & President Artelo Biosciences, Inc. is a clinical stage company focused on modifying lipid-signaling pathways to improve treatments for people living with cancer. Bridges Paliative Care Bridgespalliativecare.com Erik Soiferman Owner Bridges Paliative Care’s goal is to help you achieve the best possible outcome and overall quality of life throughout your illness. DORN Dorncompanies.com Kevin Lombardo President CEO DORN is a disruptive innovator and the country’s leading wellness-based pain management and injury prevention company, committed to reducing costs of healthcare, workers’ compensation and lost productivity. KIPUWEX OY LTD Kipuwex.com Marko Höynälä CEO & Founder KIPUWEX OY LTD is a small wireless IoT device that continuously measures different physiological parameters from the patient digitally, converting them with an algorithm into pain data and provides efficiently reliable measurements for healthcare professionals and home users. Francesca Wuttke / Xenia Riasol Founder & CEO / COO Nen provides evidence based health designed for children’s minds to improve their lives. Alan Doucet Executive Director Plymouth Bay Orthopedic Associates, Inc. goal is to help patients live a more active and rewarding life. Matt Wordley CEO Rescape California is a non-profit organization that educates about and advocates for a whole-systems approach to landscaping that works in harmony with the natural world and addresses the changing environment. Soovu Labs, Inc Soovu.com Allan Stephan Co-founder and CEO Soovu Labs, Inc helps individuals overcome pain and get back to their lives and work. Nen Nen.health Plymouth Bay Orthopedic Associates, Inc. Pbortho.com Rescape Rescape.health
  • 10. Gregory D. Gorgas President, Chief Execu ve Officer Artelo Biosciences Cover STORY
  • 11. cross the healthcare community, a serious Achallenge while delivering care is assisting patients with both acute and chronic pain management. Particularly so for people living with cancer. The initial stage of treating any disease or ailment is diagnosing the cause and treating it with appropriate interventions, including drugs or varied therapeutic approaches as required. However, a standard diagnosis- treatment-healing paradigm doesn’t always work well for a person living with cancer. Through the cancer treatment journey, a person diagnosed with cancer may encounter considerable peripheral pain (neuropathy), bone inflammation, gastrointestinal infection, low musculoskeletal functionality, or other complications. A 2020 public health research indicates that around 20% to 50% of cancer survivors experience pain. Yet, 30% of those who do not receive relief from their pain experience a negative impact on their quality of life. As cancer advances, pain can intensify by up to 80%, severely impacting a person’s quality of life. These statistics motivate the research community to discover new and robust solutions. One potential alternative emerging from clinical research on cancer pain has spotlighted the role of the body’s own Endocannabinoid System (ECS). This cell-signaling network is one of the largest in the body and is associated with regulating pain sensation. At Artelo Biosciences—a clinical-stage company using cutting-edge science to improve patient care, drug development based upon targeting the ECS is showing Artelo’s drug candidate, ART26.12 has the poten al to stand out in the market due to its poten al therapeu c value in preven ng and trea ng chemotherapy-induced peripheral neuropathy (CIPN), a common and o en painfully debilita ng complica on of cancer therapies. Most Promising Pain Management Solu on Providers in 2023 Using Cu ng-Edge Science with Lipid-Signaling Modula on to Improve Trea ng People with Cancer
  • 12. promise. The company applies leading-edge scientific, regulatory and commercial disciplines to develop innovative therapies, with a particular focus on the needs of the cancer patient. Realizing the merit of targeting the ECS, Artelo is on a mission to alter the course of treatment for those diagnosed with cancer and other serious conditions. Spearheading Artelo with innovation, conviction and leadership is the company’s President and Chief Executive Officer—Gregory D. Gorgas. Committed to improving the lives of the millions of patients worldwide with cancer diagnosis, he recruited a team of like-minded researchers, clinical professionals and business executives in San Diego and abroad to create Artelo. Acknowledging such progress at Artelo, we crossed paths with Gregory Gorgas to learn more about the company and its mission to meaningfully impact cancer care. Let’s dive in to know more! Artelo Biosciences—At a Glance! Artelo is a story of empathy, innovation and scientific revolution. Being enriched with the vision and operational experience of its CEO—Gregory Gorgas, the company aims to transform the care of a large number of people suffering through multiple diseases and conditions, including cancer, pain, anorexia, anxiety, neuropathy, and inflammation with the help of its novel product candidates in development designated as ART27.13, ART26.12, ART12.11. Aware of the tremendous promise of targeting the ECS with lipid- modifying drugs to treat cancer, pain and central nervous system (CNS)-related conditions, Artelo initiated its quest for innovative research early in 2017. By the end of that year, the company had acquired rights to multiple technologies and filed a patent on its own invention. In sum, Artelo’s portfolio represents the broadest spectrum in the pharmaceutical industry of methods targeting the ECS for the improvement of health. In early 2023, Artelo expects to start enrolling patients in the Phase 2 stage of the Cancer Appetite Recovery Study
  • 13. (CAReS) with its lead clinical program, ART27.13. Cancer anorexia (loss of appetite or aversion to food) affects over 60% of people with a cancer diagnosis and is a leading cause of death for cancer patients. ART27.13 was designed to arrest the anorexia and resulting weight loss experienced by the majority of cancer patients. Like the other programs at Artelo, ART27.13 targets the receptors of the ECS. It leverages a known effect on hunger without the undesired CNS effects of cannabis. And the company is well-funded to complete the CAReS trial as its last reported cash was nearly $20 million. Another complication of cancer is pain secondary to the toxic effects of certain cancer chemotherapies. A key initiative of Artelo is to bring its second drug candidate into the clinic within the next 18 months. In multiple preclinical animal studies, ART26.12 has shown remarkable promise in treating painful neuropathies associated with chemotherapy. Artelo’s researchers showed that ART26.12 was able to not only successfully treat the pain, but also prevent the neuropathic pain from even starting. Currently, there are no FDA-approved treatments for chemotherapy-induced peripheral neuropathy (CIPN). Artelo is on a mission to change that. Transforming Pain Management ART26.12 is a new chemical entity. Because ART26.12 is at the forefront of Artelo’s innovation, we asked Mr. Gorgas to elaborate on the science and strategy with this novel compound. He explained that ART26.12 is a selective fatty acid binding protein 5 (FABP5) inhibitor. It inhibits a pathway that can raise endogenous levels of endocannabinoids, the body’s self-made cannabinoids. ART26.12 has the potential to stand out as a treatment due to its therapeutic value in preventing and treating CIPN, a common and often painfully debilitating complication of cancer therapies that often results in a reduction or interruption of cancer treatment. CIPN is frequently so painful that patients cannot progress on their anti-cancer therapy. In preclinical models, inhibition of FABP5 using ART26.12 has shown activity in analgesia, reversing the effects of CIPN, a condition for which there are currently no approved treatments. Current pain management medications typically have significant side effects and/or addictive properties. To date, FABP5 inhibition has shown little to none of these effects while exhibiting good analgesic properties. In addition to pain, inhibiting FABP5 may be useful in other areas of unmet need. Of recent note, landmark research in anxiety with another one of Artelo’s FABP5 inhibitors was selected as one of the top 50 (out of 12,000 research studies submitted) at the Society of Neuroscience annual meeting in November 2022. The preclinical results indicated that a novel FABP5 inhibitor from Artelo’s extensive library of FABP inhibitors significantly reduced anxiety behaviors without the abuse potential or cognition blunting of other treatments for anxiety disorders. There, it was concluded that modulation of the FABP5 system might serve as a promising target for the development of novel anxiolytics. Key Development Programs Artelo’s full-spectrum approach to modulating the ECS with lipid-modifying approaches include:. Ÿ ART27.13, a cannabinoid (CB and CB ) receptor 1 2 agonist, being investigated in the CAReS trial, currently enrolling patients with cancer anorexia. Ÿ ART26.12, a fatty acid binding protein 5 inhibitor, with regulatory-enabling studies well underway aiming to have the program in the clinic for chemotherapy induced peripheral neuropathy within 18 months. A first for a FABP5 inhibitor. Ÿ ART12.11, a patented cocrystal composition of cannabidiol (CBD), in preclinical development for anxiety-related disorders including post-traumatic syndrome disorder (PTSD), as well as other potential indications. If approved by the FDA, ART27.13 in cancer anorexia and ART26.12 in chemotherapy- induced peripheral neuropathy would be first-in-class treatments for people that have no currently approved treatment op ons.
  • 14. If approved by the FDA, ART27.13 in cancer anorexia and ART26.12 in chemotherapy-induced peripheral neuropathy would be first-in-class treatments for people that have no currently approved treatment options. Artelo also believes its CBD cocrystal has the potential to be a best-in-class drug. Wholistic Thinking-Treating the Whole Person While several of Artelo’s programs may ultimately be useful as anti-cancer agents directly, Mr. Gorgas says the mission of Artelo today is to treat the whole person with cancer. While there have been many advancements in the treatment of tumors over the past two decades, cancer pain and cancer anorexia are still without FDA-approved treatments. Mr. Gorgas lamented that treatment of cancer anorexia has not advanced since he started his career in the pharmaceutical industry nearly 40 years ago, and the team at Artelo aims to change that. Using a mechanism-based approach modulating the ECS holds therapeutic promise that may have eluded research to date. Artelo’s priorties for 2023 are 1.) the rapid accrual in the CAReS Phase 2 with an expansion of clinical sites in United Kingdom and Europe, 2.) gaining alignment with the FDA on the pathway and research to bring ART26.12 Current pain management medica ons typically have significant side effects and/or addic ve proper es. But to-date, Artelo’s FABP inhibi on has shown li le-to-none of these effects while exhibi ng good analgesic proper es.
  • 15. into the clinic for CIPN (a first for a FABP5 inhibitor), and 3.) advance and expand the understaning of differentiating properties of its patented CBD cocrystal. Transformative Leadership—The Intersection of Experience and Innovation Mr. Gorgas brings almost four decades experience to his role in leading Artelo. Before founding Artelo, he served as Senior Vice President, Commercial and Corporate Officer at Mast Therapeutics, a publicly-held biotechnology company. There, he had commercial leadership accountability and business development responsibilities for the hematology, oncology and cardiovascular franchises. Prior to that, he worked at Biogen, a publicly-held biotechnology company, as Senior Director, Global Marketing, with responsibility for the strategic vision and operational commercialization of the company’s worldwide cancer business. Furthering his commitment to bring healing to people living with cancer through innovative therapeutics, Mr. Gorgas became convinced that targeting the body’s endocannabinoid system with lipid-signaling drugs could lead to new solutions to old problems. This led Mr. Gorgas to establish Artleo Biosciences. Modulating the ECS with federally-compliant cannabinoid-based drug research has some added complexity and challenges, but the transformative potential of the programs at Artelo makes it worth the effort. And Artelo has a competitive advantage of having successfully navigated complex regulations to advance its programs across the globe. Mr. Gorgas envisions benefiting millions of patients worldwide through the product development at Artelo Biosciences. The company seeks to attain this vision through the application of innovative, next-generation science to real-world challenges for people living with cancer. Currently, alongside the business potential, Mr. Gorgas and the team at Artelo derive their motivation to solve pharmaceutical challenges that have eluded the industry for decades. Words of Wisdom Years ago, Mr. Gorgas read Peter Medawar’s “Advice to a Young Scientist,” who wrote, “In choosing topics for research...to enlist in, a young scientist must beware of following fashion.” Mr. Gorgas found it to be an essential suggestion. Following fashion in science or on Wall Street often leads to dead ends. “When we started Artelo in 2017, federally- compliant research into the endocannabinoid system was very new and few dared to pursue the path, but that didn’t dissuade us. We were convinced that lipid-modulating drugs would ultimately prove their value in treating serious medical conditions like cancer pain and anorexia,” says Mr. Gorgas. “Decades of commitment and smart science pursued by pioneer researchers in the ECS like Artelo’s Chief Scientific Officer, Andy Yates, Ph.D., and Professor Saoirse O’Sullivan, Ph.D., now Artelo’s Vice President of Translational Research are beginning to pay dividends. We are excited to be a leading company with this innovation, and through our efforts we hope people with cancer will live better in the decades to come than in decades past.” Artelo Biosciences is traded on the Nasdaq Capital Markets exchange (Nasdaq: ARTL) and has analyst coverage with Ladenburg Thalmann & Co. Inc., H.C. Wainwright & Co., and Maxim Group.
  • 16.
  • 17. Stay in touch. Subscribe to Insightscare Get Insightssuccess Magazine in print, & digital on www.insightscare.com Never Miss An Issue Subscribe Today Corporate Office Insights Success Media Tech LLC 555 Metro Place North, Suite 100, Dublin,OH 43017, United States Phone - (614)-602 - 1754,(302)-319-9947 Email: info@insightscare.com For Subscription : www.insightscare.com Check should be drawn in favor of : INSIGHTS SUCCESS MEDIA TECH LLC www.insightscare.com
  • 18. Marko Höynälä CEO and Founder Kipuwex
  • 19. Kipuwex Ltd. Revolutionizing the Telehealth Industry with a Patient-Centric Approach Patients who face communication adversities, such as young children, people with mental illnesses, and critically ill patients, have difficulty being assessed for pain. Premature infants whose central nervous systems have not yet formed and may experience disastrous effects require specific attention when it comes to pain treatment. Marko Höynälä is the CEO and Founder of Kipuwex, a company that develops a small wireless IoT device that continuously records a patient's physiological parameters digitally, converts those parameters into pain data using an algorithm, and provides accurate measurements for both healthcare professionals and at-home users. Marko is a globally well-known inventor from Oulu, Finland, with global experience in multiple technology fronts, including the IoT (Internet of Things), IoMT (Internet of Medical Things), AI (Artificial Intelligence), Remote Patient Monitoring (RPM), and telehealth industries. Here are the interview specifics that shed light on the pressing need to address chronic pain assessment and how Marko Höynälä is overcoming this obstacle with Kipuwex. Kindly brief us about Kipuwex and its inception story. Chronic pain is a deeply personal issue to me, as my father suffered from cancer. I saw how destructive chronic pain can be. He couldn’t handle the pain and committed suicide. Chronic pain is one of the largest medical burdens worldwide; we can’t even measure it consistently, so how can we treat it properly? Pain is often underdiagnosed or overtreated, both of which have long-term impacts on the lives of those it affects. It was the year 2015 when I came across the local Northern Ostrobothnia Hospital District’s innovation competition, in which four major global problems were faced by healthcare professionals. One of the difficulties was objectively measuring the children's pain. I won the competition, and that was the start of the Kipuwex company. It was highly important that winning the hospital district’s innovation competition meant getting to work closely with healthcare professionals. Today, we have extended our collaborations with leading medical institutions and hospitals within Europe and Asia. At first, we started to develop an automatic and objective medical device for pain measurement, but during the journey, we changed our strategy. Kipuwex device will be launched in the healthcare market as a comprehensive remote monitoring device. In the second phase, we will integrate a pain measurement feature. What are the core values of Kipuwex, and how are you driving Kipuwex to achieve its mission and vision statement? I have over 20 years of experience in software development, so it has been very logical that our core competencies are software, developing cloud services, algorithms, applications, and all the other IoT (Internet of Things) and IoMT (Internet of Medical Things) technologies. With Kipuwex, we want to tackle three major healthcare problems. rising costs of healthcare, e.g., in the USA, 20% of GDP goes to healthcare. There's a lack of access to affordable healthcare; at least half of the world’s 8 billion people still do not have access to essential health services. Chronic pain is a major global issue, affecting 20% of Most Promising Pain Management Solu on Providers in 2023 February 2023 17|www.insightscare.com
  • 20. adults worldwide and costing $560-635 billion in the United States alone each year. "Kipuwex’s mission is to combat healthcare inequality and help millions of people." "Kipuwex’s vision is to become a world-leading company in the pain management domain." Enlighten our readers about the key products and offerings of Kipuwex and highlight any service that is its USP. Kipuwex is a small, wireless IoMT device that measures 12 different physiological parameters, including pain. The device is attached to the patient’s chest with a disposable ECG sticker. We measure more physiological parameters than any other similar device on the market. We have developed Kipuwex so that it is affordable for developing countries as well. Currently, we are developing for home users the first complete health report in the world. It's a consumer-centric digital health ecosystem for remote patient monitoring in cooperation with a unique global partnership. Also, there are well-being algorithms for preventive care and personalized heart and emotional well-being monitoring. In your opinion, what are the current challenges in the pain management industry? How are you infusing your leadership skills and expertise over the years to create a flourishing industry with opportunities and growth? The medical device business is very challenging. It’s a very long process to develop a new medical device and to launch it. The road to a successful launch can be filled with product development risks. Of course, it involves numerous legal and economic considerations, so we need to think and Kipuwex’s advantage and competitiveness are based on the fact that the company has integrated so many sensors into such a small IoMT device. February 2023 18|www.insightscare.com
  • 21. apply. Companies must comply with regulations, which can be time- and money-consuming. The biggest challenge is how to make funding last through product development and to get sufficient funding to finalize the product development. The global pandemic was a huge challenge and postponed clinical trials. Product testing should begin early in the development process and continue throughout. The war in Ukraine has caused a lack of components. The present research is serving as the baseline for better future strategies to improve global health initiatives, as our ecosystem is very scalable and can be integrated as well. We are getting continuous questions, is it possible for third parties to integrate our platform in their own use cases? Opportunities are quite endless when thinking of growth potential. What are the latest technological advancements adopted by Kipuwex to deliver the best pain management services in the industry? How is it impacting the demographic concerned? Kipuwex product is protected by patents and know-how. Our advantage and competitiveness are based on the fact that we have integrated so many sensors into such a small IoMT device. For the pain measurement feature, we are granted two patents, which are essential and extremely important to stimulate the innovation, development and commercialization of Kipuwex. As an experienced leader, what would be your advice for aspiring entrepreneurs and enthusiasts who wish to venture into the MedTech sector? Being an entrepreneur is difficult, especially in the MedTech industry, which is difficult in many ways. It also needs years of hard work to go to market. You must have a strong vision, mission and problem-solving abilities that are more than just business to you. What are the future goals of Kipuwex, and How do you envision scaling up its operations and reach in 2023 and beyond? Kipuwex's mission is to provide remote monitoring devices throughout the world. Our vision is to become a world- leading company in the pain management domain. The Words that Signify a Bequest “Billions of people still do not have access to essential health services, and at the same time, health care costs are unsustainable across the world. Next generation sensor technologies, in combination with smart algorithms, bring unlimited opportunities to ensure accessible and affordable healthcare solutions. Kipuwex remote monitoring device is well positioned to play an important role in revolutionizing the integration of quality healthcare outside hospitals.” Ÿ Prof. Dr. Niclas Adler, CEO and Founder of Adler Industries. CEO and Founder of Synthesis Group, iHealth Solutions, and iPower Group. Stockholm, Sweden “Kipuwex is one of the state-of-the-art devices for pain management, which is the need of the hour in this era of digitalization and can revolutionize pain management in certain sectors of the population. It also has the promise of being utilized as a unique remote vital parameter monitoring device such as in emergency kits, and such devices have now become a necessity.” Ÿ Prof. Dr. MCh. B J Rajes, Consultant Neurosurgeon at Yashoda Hospitals, Hyderabad, Telangana, India February 2023 19|www.insightscare.com
  • 22. Management Explanation to ince pain is a subjective experience, each person Sexperiences it differently. Physical or psychological pain can affect a person's mental and emotional well- being. Torment the board includes various strategies and techniques to assist people with dealing with their aggravation. Psychological explanations for pain management can also be beneficial, in addition to physical treatments like therapy and medication. Let's examine the psychological basis for pain management and its benefits! Understanding the Psychological Basis for Pain Management Psychological pain management entails the application of a variety of strategies to assist individuals in coping with pain. According to the psychological explanation of pain management, pain is both a physical and a psychological experience. This indicates that a person's thoughts, feelings and actions can impact pain. According to the psychological explanation of pain management, these psychological factors can be addressed to manage pain. For instance, a person's perception of pain can be influenced by their beliefs. A person's pain may become more severe if they believe it is intolerable and unmanageable. However, people may feel more in control of their pain if they think it can be managed. Reconceptualizing Pain Fear of pain is normal because it is a natural learning tool and a horrible feeling. Patients who experience persistent pain tend to develop a fear of pain and, as a result, stop doing activities that make them feel pain, such as moving their bodies, which is typical of osteoarthritis. Through education, rethinking pain, cognitive behavioral therapy (CBT), and the other methods on this page, the cycle of chronic pain and disability can be broken. This fear of pain can become a cycle that never ends. February 2023 20|www.insightscare.com
  • 23.
  • 24. Cognitive Behavioural Therapy (CBT) One approach for psychological pain management is cognitive behavioral therapy (CBT). The goal of cognitive behavioral therapy is to assist people in recognizing and altering negative thoughts and actions that cause pain. CBT, for instance, can help people challenge the belief that they are weak or damaged due to pain and develop more positive and realistic views. Mindfulness Care is one more method utilized in the mental torment of the board. Being aware of the present moment and accepting it without judging it is mindfulness. Stress and anxiety can be reduced through mindfulness, which can assist individuals in pain management. Stress and nervousness can exacerbate the aggravation, so diminishing these feelings can assist with overseeing torment. Massage Massage treatment, like unwinding, is commonly utilized as an assistant to conventional treatment modalities. It is generally used close by and contrasted with unwinding and other mental medicines, so remembering was considered advantageous. Since its inception in the 2nd century BC, massage therapy has developed numerous techniques and subfields, including Swedish massage, Shiatsu, Rolfing, reflexology, and craniosacral therapy. In one of the studies, massage was more effective than a placebo treatment. In the remaining seven studies, there was no significant difference between exercises and corsets, and the massage was superior to relaxation, acupuncture and education. Relaxation Therapy Relaxation can take a variety of forms, including spiritual or non-spiritual meditation, progressive relaxation or muscular contraction and relaxation, and even imagery. It is generally used in conjunction with other treatment modalities. Typically, relaxation is considered an "Alternative" treatment that must be used in conjunction with conventional medical care rather than on its own. This could be because the treatment's theoretical foundations haven't been proven or there isn't enough high-quality evidence to support it. Restoring normal equilibrium within the body's systems is one way that relaxation therapy may be effective. This can be accomplished by reducing the effects of stress on the body. The body's most fundamental response to stress is a "fight or flight" response that triggers several biochemical changes. Benefits of Psychological Explanation to Pain Management The psychological explanation for pain management has numerous advantages over spinal manipulation and transcutaneous electrical nerve stimulation in terms of effectiveness. First, it can give people a sense of control over their pain. People may feel more empowered to manage their pain when they realize their thoughts and actions can affect it. Self-confidence and self-esteem may rise as a result. Second, these methods may lessen the requirement for medication. Medication can potentially alleviate pain, but it can also have adverse effects and become addictive. Psychological techniques can be used to manage pain independently or with medication. Thirdly, psychological pain management has the potential to enhance a person's quality of life. Torment can essentially affect an individual's psychological and profound prosperity. People can improve their mood, reduce stress and anxiety, and participate in more social activities by controlling pain. In sum-up, The psychological explanation of pain management suggests that pain is a psychological and a physical experience. People can better manage their pain by addressing the psychological factors that cause it. Psychological methods for managing pain, such as cognitive behavioral therapy (CBT) and mindfulness, can give people a sense of control over their pain, lessen the need for medication, and raise their overall quality of life. Talking to a medical professional about psychological pain management methods might be helpful if you are having pain. - Shreyasi Shelke February 2023 22|www.insightscare.com
  • 25.
  • 26. Nen Evidence Based Solution S.L.U. (nen) A Pain Management Solu on, Designed for Kids Figh ng Cancer ediatric cancer is a global problem that children and Ptheir families struggle with. Almost 500,00 children will be diagnosed with cancer this year and nearly all of the will experience pain during their first year. Pain management in children remains an enormous unmet medical need that is not currently served by current practices. Because of the relative homogeneity of pain in cancer (procedural pain and pain from cancer itself), Nen Evidence-Based Solution S.L.U. (nen), a clinical-stage company is developing evidence-based digital therapeutics to help kids fighting cancer, their families and their doctors manage pain. Pain management is addressed through play, by leveraging gamification of cognitive behavioral therapy to modulate pain and improve a child's overall well-being and outcomes. Through validated outcome measures, both families and physicians can provide insightful and tailored pain management support to children who currently lack alternative means to express their needs. With the support of Francesca Domenech Wuttke (Founder & CEO) and Xènia Riasol Cercos (COO), nen is a mission-driven profit-for-purpose company to democratize pain management at scale to all kids who are in pain, wherever they are. Let's dive in to learn about Nen's operations in meeting its objective. What inspired you to establish Nen Health? When I started thinking about my next steps, I wanted to do something with a more direct patient impact. I put my consulting hat back on and did a scan of the whole of the digital health market to identify gaps. I wanted to know what those gaps are and if can they be filled with a digital solution or service but more specifically with a digital therapeutic. I feel strongly that DTx is the fourth wave of medicine: small molecules, biologics, cell and gene therapy, and now digital therapeutics. I was surprised by the dearth of activity in the pediatric digital health space and had worked on a DTx for pain in adults and saw how readily the CBT modules could be translated to a digital platform and thought why not apply that to kids that were the genesis of nen. What are the core values of the company? How are you driving the company to achieve its mission and vision statement? nen is focused on developing kid-centric care designed for their minds- because kids matter and we are committed to kids. nen offers a novel mission-driven approach to address pain management through play leveraging gamifica on approaches and cogni ve behavioral therapy (CBT) to modulate pain and improve their overall well-being and outcomes. We are crea ng an app-based pla orm for smartphones/tablets. The CBT modules will be age- appropriate and designed for children to be engaging and enjoyable for them. Most Promising Pain Management Solu on Providers in 2023 February 2023 24|www.insightscare.com
  • 27. Francesca Wu ke is the CEO and Founder of nen-bringing evidence- based Digital Therapeu cs (DTx)pain solu ons to kids with cancer. Dr. Wu ke brings broad drug development and healthcare exper se in both the US and Europe, with nearly 30 years of clinical, commercial, strategic and transac onal experience. She has worked with diverse organiza ons including start-ups, consul ng, large and specialty pharma as well as academia. Formerly, she was the Chief Digital Officer of Almirall where she created the Almirall Digital Garden to accelerate and incubate digital health startups. Dr. Wu ke worked at Novar s where she was responsible for two Cell and Gene therapy opportuni es that were successfully brought into the organiza on as well as managing the strategy and commercializa on for the exis ng por olio of cell therapy assets. Dr. Wu ke holds a Ph.D. in Pharmacology from Weill Cornell Graduate School of Medical Sciences and a BA from Cornell University College of Arts and Sciences. About the Founder Francesca Domenech Wu ke Founder & CEO Nen Evidence Based Solu ons, S.L.U. (nen) About the Founder February 2023 25|www.insightscare.com
  • 28. About the COO Xènia Riasol is the Chief Opera ng Officer of nen. She is experienced in launching digital therapeu cs across Europe and in crea ng and deploying customer-centric digital solu ons globally. Xenia is a digital innova on and strategy expert with a focus on commercializa on models and global solu on deployment. She has extensive experience in Pharma, where she was bringing digital innova ve solu ons to pa ents and managing strategic digital marke ng campaigns globally. As Chief Opera ng Officer, Xenia is responsible for leading the product planning and evolu on, marke ng strategies, and for the everyday running of the business, turning industry knowledge into ac onable business channels and revenue streams for the company. She works with investors, partners, advisors and pa ents to manage the strategy and path forward for nen. Xènia Riasol Cercos COO Nen Evidence Based Solu ons, S.L.U. (nen) About the COO February 2023 26|www.insightscare.com
  • 29. How big is the addressable market? Pain management in children remains an enormous unmet medical need that is not currently served by current practices. To date, no current solutions exist to moderate pain designed specifically for kids. The current modalities including pain assessment and then treatment scales are incredibly subjective and not appropriately modified for use in children, particularly in small children. nen offers a novel mission-driven approach to address pain management through play leveraging gamification approaches and cognitive behavioral therapy (CBT) to modulate pain and improve their overall well-being and outcomes. We are creating an app-based platform for smartphones/tablets. The CBT modules will be age- appropriate and designed for children to be engaging and enjoyable for them. Who are your target customers? nen's first indication is for school-aged children from 7-12 years old, as they have more developed neurodevelopmental skills where CBT is considered a clinically validated and well-established therapy. After we have established a solid and tested the regular nen solution (with proven efficacy and learnings) nen will continue to develop the platform to serve patients from 2-6 as this age group remains a huge unmet need as very few digital solutions for pain management are addressed specifically to them and yet they too suffer from pain (both physically and psychologically). We will then expand to adolescents. As an experienced leader, what advice would you like to give to aspiring entrepreneurs and enthusiasts who wish to venture into the competitive industry that you are serving? Patience and resilience. There will be a lot of no's along your path but if you stay true to your mission and vision you can achieve great things. What are the future goals of the company? How does it envision scaling up its operations and reach in 2023 and beyond? We have designed our business model with flex so that we are not reliant on the ever-changing regulatory landscape. Ÿ B2C: The first iteration is a pediatric oncology patient support tool, designed for GDPR/HIPAA and ISO compliance at inception and with parallel development in US and Europe in English (UK and American) Spanish, French, Italian, German, and Dutch. This tool will initially be targeted to parents so we can beta-test the outcomes. We expect to launch this product in late 2023 and then after it is clinically validated, we will offer a premium product (identical to the PDT) with robust medical claims at a higher price point. Ÿ B2B: Next, we will continue to forge research collaborations with academic institutions to generate clinical evidence while gaining champions. Ÿ Rx: Standalone Prescription Digital Therapeutic (PDT.) Once registered as SaMD, or under DiGA or similar laws, we will seek reimbursement as a standalone PDT across various payor systems, models and geographies. February 2023 27|www.insightscare.com
  • 30. Rescape Innovation Limited Reducing Pain and Anxiety Through Virtual Reality n several healthcare specialisms, doctors and Icaregivers are often puzzled about the best way to help their patients cope with pain and anxiety, two dominant concerns of their suffering. This is because patients during treatments are usually focused on their pain, which increases their perception of pain. Not only do they feel anxious about it, but they also end up feeling helpless and out of control over the situation. In response to such a pain dilemma, distraction has proven to be an effective coping tool to help patients reduce their pain and anxiety. It encourages them to focus on a specific task (i.e., a pleasurable activity, puzzles, games, etc.) and attain a sense of control. With the proven effectiveness of distraction as a tool, Rescape Innovation Limited provides a unique solution to ease the lives of patients. Its Class-one innovative medical device, DR.VR™, enables quick, easy and monitorable deployment of virtual reality therapy to improve the patients' reported level of pain and has been effective compared to opioid analgesics. In an interview with Insights Care, Matt Wordley, the CEO, talks about the role of virtual reality in clinical practice, along with Rescape's contribution in delivering it to improve the experience of patients' pain and anxiety. Below are the highlights of the interview. Kindly brief us about the company and its inception story. Rescape Innovation was born when I attended a TED talk by a palliative care consultant, Professor Mark Taubert, who explained the difficulties of communicating with his patient cohort. There I developed an interest in immersive technology through other business interests and felt that I would be able to use the technology to address some of the issues that had been raised in the TED talk. I spoke to Professor Taubert immediately after the talk and the journey of Rescape began! Please tell us about yourself and your professional journey so far. I am one of the original creators of The Orchard Media Events Group. I have been instrumental in building it into a world-class agency, TV production company and Live Music promoter. As an earlier adopter and advocator of VR technology within Orchard, Rescape was spun out to unlock the healthcare opportunity, and I took the reigns as CEO. What are the core values of the company? How are you driving the company to achieve its mission and vision statement? Very early on we saw the impact that Virtual Reality Therapies could have on patients' pain and anxiety. This was anecdotal but very clear and we started to evidence this impact. We committed then to helping as many patients as possible have access to VR treatments. This core value is an important principle we try to benchmark everything we do against. VR should be available to all and we're determined to deliver against this promise. Could you please list the key products and offerings of the company? Also, please put light on any service that is the company's USP. DR.VR is a Class 1 medical device that is being utilized by hospitals, care homes and hospices to alleviate anxiety and reduce the perception of pain for patients and family members of patients. Another product is Frontline, which has been designed to support the well-being of NHS staff and has also been adopted by several universities to support staff and students. February 2023 28|www.insightscare.com
  • 31. The priority for our development team is on ensuring that user-centric design is at the heart of all we do as that gives us the ability to deploy simple solutions at scale, ensuring that the benefits of immersive therapeutics are enjoyed by as wide an audience as possible. In your opinion, what are the current challenges in the pain management industry? How are you infusing your leadership skills and expertise over the years to create a flourishing industry with opportunities and growth? We are at the beginning of a fundamental shift in medicine adopting a more holistic view of the patient. Historically mental and physical health have been treated independently as if they were unconnected and this divide is very slowly being bridged. Pain is a complex, multifaceted biopsychosocial problem that requires a solution that addresses multiple elements concurrently and chronic pain clinics are now starting to use a multidisciplinary approach to treatment involving psychiatrists, psychologists, anesthetists, physiotherapists, nurses and occasionally social workers. Our job is to build the evidence base to prove that Immersive Therapeutics should be an important component in treating pain by addressing mental and physical health at the same time and become a mainstay in the suite of treatment options to help patients. What are the latest technological advancements adopted by your company to deliver the best pain management services in the industry? How is it impacting the demographic concerned? We call ourselves pragmatic technologists; the real world is never easy and always messy. We are proud that our DR.VR solution is user-friendly for both patients and clinicians. We have a phrase we use when developing content "Don't create things to watch but space to inhabit." This is a key remit for successful VR pain therapies; the deeper level of immersion we create, the more success we can create. As an experienced leader, what advice would you like to give to aspiring entrepreneurs and enthusiasts who wish to venture into the competitive industry that you are serving? Understand the complete system you are trying to work within. Sadly it's not good enough to just create a Virtually Reality that has therapeutic benefits. You have to deliver a simple and deployable solution. Read up, research and Very early on we saw the impact that Virtual Reality Therapies could have on patients' pain and anxiety. This was anecdotal but very clear and we started to evidence this impact. Based on the Virtual Reality principle, our innovative product, DR.VR, is a Class 1 medical device that is being utilized by hospitals, care homes and hospices to alleviate anxiety and reduce the perception of pain for patients and family members of patients. Matt Wordley CEO Rescape innovation Limited Most Promising Pain Management Solu on Providers in 2023 February 2023 29|www.insightscare.com
  • 32. embrace user-centric design practice and you will develop much better solutions. At times that means embracing the elephant in the room and tackling the hard things head-on. There are so many examples where we have done this from a lack of NHS wifi to infection control protocols or making sure our content reduces motion sickness. What are the future goals of the company? How does it envision scaling up its operations and reach in 2022 and beyond? The opportunities for the use of VR in healthcare are in their infancy. We have several exciting research projects that will be concluding in 2023 and we're excited about the opportunities this will open. Referencing our core values, we want to give access to as many people as possible and in '23 we will be launching a pain solution that can be accessed from home. This in part, is driven by a growing number of patients that have asked if they can use the solution at home. Give us a few testimonials from your clients or customers and awards or recognition that accurately highlight your company's position in the market. "VR intervention demonstrated a significant reduction in patient and parental anxiety both pre-operatively and in the fracture clinic." "The improvement in patients' reported pain after VR, particularly for those patients with higher pain scores (3.41 points out of 10), was remarkable and is comparable with opioid analgesics." Dr. Ceri Lynch, published in ICU Management. “91% [of patients] reported lower anxiety levels after using the headset." Potter, T., Curran, Jr, 2021 Using DR.VR® in a Burns Unit "I have been a nurse for over 25 years, working mainly in cancer and palliative care, and this was probably one of the most amazing, moving and beautiful experiences I have witnessed." Gillian, Lead Nurse, Marie Curie Hospice, Newcastle "The mindfulness areas teaching me how to calm and breathe were amazing for my worry and anxiety." PID 105, FRONTLINE RELIEF: A brief evaluation "I think it's really good for taking you out of a stressful environment and calming you down. I like that there were lots of different options for what to do because people have very different preferences." University Hospital Bristol & Weston Evaluation Documentation February 2023 30|www.insightscare.com
  • 33.
  • 35. Manage Pain Effective Techniques Used to How to Overcome? ain is an experience that affects people of all ages, Praces and genders. It is a universal feeling. Several things, like injuries, illnesses and long-term conditions, can bring it on. Because it can increase a patient's capacity for daily activities and improve their quality of life, pain management is an essential part of healthcare. The two most common types of pain are acute and chronic. Acute pain is typically brought on by a sudden occurrence such as surgery, bone fractures, infections, cuts and lacerations, falls, and burns. A doctor usually treats acute pain immediately following the triggering event. The pain typically subsides as the injury or condition heals, generally disappearing within six months. Let's have a look at techniques to manage pain! Medication Prescriptions are, much of the time, the primary line of treatment for torment. They fall into one of two categories: opioid and non-opioid drugs. Over-the-counter pain relievers like acetaminophen and ibuprofen and prescription medications like non-steroidal anti-inflammatory drugs (NSAIDs) are examples of non- opioid medications. Drugs like morphine, oxycodone and fentanyl are some examples of opioids. Physical Therapy Another effective method for managing pain is physical therapy. It involves stretching, exercises, and other physical methods to increase mobility and decrease pain. Patients with musculoskeletal conditions like back pain, arthritis and fibromyalgia may benefit most from physical therapy. Actual advisors can work with patients to foster individualized treatment designs that focus on the underlying driver of their aggravation. These plans may include manual therapy, therapeutic exercise, and other heat or cold therapy treatments. February 2023 33|www.insightscare.com
  • 36. Psychological interventions These interventions, like mindfulness meditation and cognitive-behavioral therapy (CBT), can also be helpful in pain management. Positive thought patterns that can exacerbate pain are identified and changed in CBT. Care reflection includes zeroing in on the current second and tolerating actual sensations without judgment. Patients may benefit from these methods in developing coping mechanisms that lessen the impact of pain on their daily lives. They can also improve mood and lower stress levels, which can help break the cycle of chronic pain. Chronic Pain Finding the most effective pain relief methods for one's condition can take some time due to the complexity of chronic pain. Yoga, drug treatments, and hot and cold therapy are just a few options available. An injury or a medical condition can lead to chronic pain. If pain persists for more than three months, or if it continues beyond the standard healing period for the underlying condition or injury, it is considered chronic. It can impact everything from a person's work and social life to their sleep and mental health. The Centres for Disease Control and Prevention (CDC) estimated that approximately 20% of adults in the United States had chronic pain, with 8% experiencing high-impact chronic pain. According to the Trusted Source Global Burden of Disease Study from 2017, chronic pain and related diseases are the leading causes of disability worldwide. It has a relationship with various physical and psychological well-being conditions, including wretchedness, rest issues, social segregation and abuse of prescription. Techniques to Overcome Chronic Pain Hot and cold treatment Hot and cold treatment is a typical and safe method to lessen torment. Intensity can assist with loosening up the muscles and enlarging the veins. It can also help wounds heal after an accident. Cold therapy reduces pain-causing inflammation and blood flow. The skin is frequently treated with an ice pack wrapped in a towel. Acupuncture A practitioner performs acupuncture by inserting fine needles into the skin at specific points on the body. The National Centre for Complementary and Integrative, Health Trusted Source says that there is evidence to suggest that this method could assist individuals in managing certain pain conditions. This includes temporary relief from osteoarthritis and lower back, neck and knee pain. However, there is little evidence to suggest that it is long- lastingly effective. Acupuncture has been suggested to alleviate pain, reduce inflammation, promote relaxation and lessen muscle spasms. When performed by trained practitioners with sterile needles, acupuncture is generally safe. Mind-Body Practices Yoga Yoga uses specific poses that target specific body parts to relax, strengthen and keep the body flexible. A report in 2010, into yoga's consequences for ongoing torment, found that it didn't diminish members' aggravation. Yet, it assisted them with adapting, and they were more in charge of what their aggravation meant for their day-to-day existence. On the other hand, yoga has been shown to reduce pain in other studies. It is a safe and easy way to manage pain. You can try it at home, watching videos online, or in a class with a teacher. In conclusion, Managing pain and chronic pain can be done in several ways, many of which are accessible and straightforward to use. Most pain management methods aim to lessen or enhance a person's capacity to cope with chronic pain. A professional therapist should be used for pain management techniques like acupuncture, physical therapy and yoga to ensure anyone can safely practice them. - Shreyasi Shelke February 2023 34|www.insightscare.com
  • 37.
  • 38. Soovu Labs, Inc. Relieving Pain Through an Innovative Heat Delivery Approach he old wives’ tale of taking out hot water bottles to Treduce body pain has some truth in it. And science is taking it seriously. Heat provides comfort to the body, and can reduce pain at the receptor level with the right temperature and application. Soovu Labs, Inc. has used this mechanism at its core for the discovery of new drug-free pain relief treatments. While it's difficult to use electric heating pads and hot tubs on the go and steady high temperatures can damage the skin, the company has solved these challenges with its Soovu™ Pain Relief System. Soovu™ is a wearable pain relief device with patented HeatWave™ technology that pulses waves of heat at optimal temperatures to the area that hurts, for effective, targeted pain relief. This device delivers fast and effective relief, leaving users pain-free and comforted. Following are the key benefits that set the Soovu™ device apart from other heat-delivery mechanisms. Ÿ Relief starts in as little as five minutes. Ÿ Lasting relief up to 3.5 hours. Ÿ 61% pain reduction after eight weeks. Ÿ Wireless and can be used on-the-go. In an interview with Insights Care, Allan Stephan, the CEO and Co-founder, talks in-depth about the company's innovation in treating pain drug-free. Following are the excerpts from the interview. Kindly brief us about the company and its inception story. Soovu Labs is transforming the treatment of pain by providing safe, effective alternatives to pills and invasive procedures. The company was founded by two board- certified pain specialists who grew increasingly frustrated watching many patients’ lives compromised by opioid dependence and other patients demoralized after numerous procedures failed to meaningfully reduce their pain. After securing funding from the National Institutes of Health, they teamed up with Allan Stephan, a seasoned engineer and product design executive, to develop the Soovu™ wearable thermal neuromodulation system for pain relief. Please tell us about yourself and your professional journey so far. I work on solving complex problems and have a special appreciation for the different skills and effort required to unlock puzzles. An engineer by degree, I founded my first company, Stratos, a multi-discipline product development firm, in 1987. Stratos' clientele included venture capital back companies and major organizations like Apple, Microsoft, Intel, Google, Amazon, Boston Scientific, Medtronic, and Abbott. I incubated several emerging companies in wearable computing, medical devices and life sciences within Stratos. VoxWare acquired Inroad (wearable computer) in 2000. Sony acquired Micronics (microfluidic diagnostics) in 2010. Millipore acquired Amnis (imaging flow cytometry) in 2010. Roche acquired Stratos Genomics (DNA sequencing) in 2020. In 2016, I stepped down from Stratos to lead my remaining incubation to address the world's pain epidemic, Soovu Labs. What are the core values of the company? How are you driving the company to achieve its mission and vision statement? Soovu Labs' objective is to help everyone be the best they can be. I surround myself with incredible people, clear their paths, and let them roll out solutions. Most Promising Pain Management Solu on Providers in 2023 February 2023 36|www.insightscare.com
  • 39. Allan Stephan Co-founder and CEO Soovu Labs, Inc. February 2023 37|www.insightscare.com
  • 40. Unlike typical pain relief solutions, Soovu delivers relief within 5 minutes of the first heat therapy, is drug-free, and can be used discreetly and safely at work, home, rest or play. Quick and e cient pain relief can improve mobility, mood, sleep and productivity as well as reduce the need for pain medication and pain therapies. Could you please list the key products and offerings of the company? Also, please put light on any service that is the company’s USP. Soovu Labs’ flagship product is the Soovu™ Pain Relief System, an FDA-registered class II medical device for the temporary relief of chronic and musculoskeletal pain and menstrual discomfort. Soovu is available without prescription and is currently marketed as a drug-free workforce pain management solution. Unlike typical pain relief solutions, Soovu delivers relief within 5 minutes of the first heat therapy, is drug-free, and can be used discreetly and safely at work, home, rest or play. Quick and efficient pain relief can improve mobility, mood, sleep and productivity as well as reduce the need for pain medication and pain therapies. In your opinion, what are the current challenges in the pain management industry? How are you infusing your leadership skills and expertise over the years to create a flourishing industry with opportunities and growth? The greatest challenge of pain is treating it without creating even more dangerous outcomes. Whether from addiction to opioids or death from heart attacks, strokes, and organ injury from NSAIDs, treating pain is a risk. My career has been looking at problems from non-traditional angles to see what others missed. We are advancing knowledge beyond existing therapies by looking at pain's pivotal role in the immune system. We see variations of our work in pain management rolling out for years to come. What are the latest technological advancements adopted by your company to deliver the best pain management services in the industry? How is it impacting the demographic concerned? The Soovu™ Pain Relief System targets the TRPV1 receptor, which was the focus of Nobel Prize-winning research in 2021 on temperature and pressure-sensitive receptors. Soovu's patented HeatWave™ thermal neuromodulation technology desensitizes the TRPV1 receptor to block the pain response for several hours. Soovu delivers relief within minutes, on par or faster than most medications, and does so without the risk of severe side effects. Its portable form factor and ability to use on the go make Soovu an ideal drug-free pain relief solution for individuals who need relief as they carry on with their lives. February 2023 38|www.insightscare.com
  • 41. As an experienced leader, what advice would you like to give to aspiring entrepreneurs and enthusiasts who wish to venture into the competitive industry that you are serving? If you aren't a natural salesperson, get yourself an equal partner because success is creating something people are willing to buy, and it takes longer than you'll imagine. What are the future goals of the company? How does it envision scaling up its operations and reach in 2023 and beyond? Establishing Soovu as the safest and most enjoyable method of pain reduction will always be our goal. This year, we are kicking off pilot trials with major corporations to address the enormous negative impact employees in pain have on an organization's profitability while demonstrating Soovu's positive impact on employees’ lives. Soovu will eventually address clinical pain applications and consumer solutions in years to come. Give us a few testimonials from your clients or customers, and awards or recognition that accurately highlight your company’s position in the market. “Soovu helps me get back to active life” “The first time I used my Soovu I had muscle spasms in my back, typically I need a chiropractor or massage therapy to work those out, but when I put Soovu on it helped calm the muscles down. My Soovu has become a very useful tool for when I overdo it one way or another to help me get back to active life.” - Erik L, Soovu User Entrepreneur, suffers from arthritis, avid athlete. “I bring Soovu with me and use it at work” "Soovu helps me pinpoint the area that is hurting. For me, it's instant satisfaction. I like that I can stick it on wherever I want and go on with my day, so I am not stuck on the couch. I bring the kit with me and use it at work. I let some of my co-workers borrow my pods and they swear by it, my wife loves it, it’s a great product.” - Scott S, Soovu User Building Engineer, suffers from chronic back pain from injury. “For me, relief was pretty much immediate and long- lasting” “I recently had a baby and I’ve had a lot of lower back pain since then. Since I’ve been breastfeeding, I try to minimize medications for pain and just take an occasional Tylenol, so to have Soovu as an adjunct therapy for pain has been incredibly helpful. I’ve used heat in the past to help with pain, but Soovu is different. You can feel the heat right away, in a very targeted place where you feel pain. Relief was pretty much immediate for me and long-lasting." - Sheena H, Soovu User Anesthesiologist/Pain Physician, suffers from back pain. February 2023 39|www.insightscare.com