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Kegg database resources

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Kegg database resources

  1. 1. INTRODUCTION: Kyoto Encyclopedia of Genes and Genomes(KEGG): “It is a collection of online databases dealing with genomes, enzymatic pathways, and biological chemicals.” • Pathway database • Record networks of molecule interaction
  2. 2. OBJECTIVES: • Computerize current knowledge of biological systems & provide consistent annotations. • Maintain gene catalogs for sequenced genomes. • Maintain catalogs of chemical reactions in living cells by LIGAND. • Provide new informatics technologies toward predicting biological systems and designing further expriments.
  3. 3. DATABASE OF KEGG KEGG maintain 6 main databases:  KEGG Pathway(Atlas)  KEGG Genes  KEGG Genome  KEGG Ligand  KEGG BRITE  KEGG Cancer
  4. 4. KEGG PATHWAY “KEGG PATHWAY is a collection of manually drawn pathway maps representing our knowledge on the molecular interaction and reaction networks for:”  Metabolism  Genetic Information Processing  Environmental Information Processing  Cellular Processes  Organismal Systems  Human Diseases  Drug Development
  5. 5. KEGG: METABOLIC PATHWAY
  6. 6. KEGG GENES: Collection of gene catalogs for all complete genomes Four types:  MGENES (Meta Genomes)  VGENES (Viral Genome)  DGENES (Draft Genome)  EGENES (EST datasets)
  7. 7. KEGG GENOME Collection of KEGG organisms which are the organisms with known complete genome sequence.
  8. 8. KEGG LIGAND:
  9. 9. KEGG BRITE: Collection of manually created hierarchical text files capturing functional hierarchies of various of biological objects, especially those represented as kegg object.
  10. 10. KEGG CANCER:
  11. 11. Applications:  Use to detect functionally related enzyme clusters.  Automatic detection of conserved gene clusters in multiple genomes by graph comparison.  Modeling & Stimulation  Browsing and retrieval of data
  12. 12. CONCLUSION: The Kyoto Encyclopedia of Genes and Genomes is a vast library of information gathered from fully sequenced genomes, genes, proteins, pathways, and chemical compounds pertaining to over a hundred different species of both prokaryotes and eukaryotes.

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