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Systemic lupus /certified fixed orthodontic courses by Indian dental academy


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Systemic lupus /certified fixed orthodontic courses by Indian dental academy

  1. 1. Systemic Lupus Erythematosus (SLE) INDIAN DENTAL ACADEMY Leader in continuing dental education
  2. 2. Autoimmune Diseases Autoimmune Disease Systemic Autoimmune Disease Responses seen in SLE Autoantibodies found in SLE
  3. 3. Systemic Lupus Erythematosus Course of Disease & Causes of Death Clinical Symptoms What causes these symptoms?
  4. 4. What Causes SLE Cause is unknown Possible factors  Genetic  Environmental
  5. 5. What Happens? Loss of self-non-self recognition Diversification of antigen-driven responses Hyperactivity of T & B Cells Formation of immune complexes Type III hypersensitivity reaction
  6. 6. Loss of T-cell Tolerance  T-Cells found in healthy & diseased patients  Loss of self-non-self recognition allows T-Cells to react with self antigen
  7. 7. Pathogenesis once T-cell tolerance is lost
  8. 8. Type III Hypersensitivity Reaction (Immune Complex-Mediated) Hyperactivity of T and B-cells Formation of immune complexes Clearance via the complement system Type III Hypersensitivity Reaction Tissue damage
  9. 9. Therapies for SLE 1st Therapies Cytotoxic drugs Current Therapies Immunosuppressions Cyclophosphamide Mycophenolate Mofetil Future Therapies Hormonal modulation Cytokine inhibition
  10. 10. Key Concepts * Self-non-self * Specificity Memory
  11. 11. References  Baechler E, Gregersen P, Behrens T. 2004. The emerging role of interferon in human systemic lupus erythematosus. Current Opinion in Immunology 16: 801-807.  Blatt N, Glick G. 1999. Anti-DNA autoantibodies and systemic lupus erythematosus. Pharmacology and Therapeutics 83: 125-139.  Brogan P, Dillon M. 2005. Autoimmune diseases in children. Current Paediatrics 15: 23-31.  Franchin G, Peeva E, Diamond B. 2004. Pathogenesis of SLE: implications for rational therapy. Drug Discovery Today: Disease Mechanisms 1: 303-308.  Hoffman R. 2004. T cells in the pathogenesis of systemic lupus erythematosus. Clinical Immunology 113: 4-13.  Kaplan M. 2004. Apoptosis in systemic lupus erythematosus. Clinical Immunology 112: 210-218.  Renaudineau Y, Pers J, Bendaoud B, Jamin C, Youinou P. 2004. Dysfunctional B cells in systemic lupus erythematosus. Autoimmunity Reviews 3: 516-523.  Sidiropoulos P, Bertsias G, Kritikos H, Boumpas D. 2004. Therapeutic strategies for refractory systemic lupus erythematosus. Drug Discovery Today: Therapeutic Strategies 3: 375-382.  Singh R. 2004. Prevention and control of reciprocal T-B cell diversification: implications for lupuslike autoimmunity. Molecular Immunology 40: 1137-1145.  Tsukamoto H, Horiuchi T, Kokuba H, Nagae S, Nishizaka H, Sawabe T, Harashima S, Himeji D, Koyama T, Otsuka J, and others. 2005. Molecular analysis of a novel hereditary C3 deficiency with systemic lupus erythematosus. Biochemical and Biophysical Research Communications 330: 298-304.
  12. 12. Thank you For more details please visit