Neural crest cell /certified fixed orthodontic courses by Indian dental academy

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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.

Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078

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Neural crest cell /certified fixed orthodontic courses by Indian dental academy

  1. 1. NEURAL CREST CELL & DEVELOPMENT OF SOFT TISSUE OF FACE INDIAN DENTAL ACADEMY Leader in continuing dental education www.indiandentalacademy.com www.indiandentalacademy.com
  2. 2. Embryogenesis is divided into three phases • Pre implantation period (first 7 days) • Embryonic period (next 7 weeks) • Fetal period (3 – 9 months) www.indiandentalacademy.com
  3. 3. zygote zygote Morula Morula Germ layers Germ layers Ectodermal cells Ectodermal cells Primitive streak Primitive streak Notochord Notochord Neural plate Neural plate Neural crest cells Neural crest cells www.indiandentalacademy.com
  4. 4. Embryology– first week www.indiandentalacademy.com
  5. 5. Second week Epiblast // ectoderm Epiblast ectoderm 2nd germ layer 2nd germ layer Embryo resembles disc Embryo resembles disc Bilaminar embryonic disc www.indiandentalacademy.com
  6. 6. Second week Heusers membrane www.indiandentalacademy.com
  7. 7. Second week • FORMATION OF PROCHORDAL PLATE Bilaminar disc Bilaminar disc Hypoblast cells- columnar Hypoblast cells- columnar Indicates the future site of mouth Indicates the future site of mouth Cranial region of embryo Cranial region of embryo www.indiandentalacademy.com
  8. 8. 3rd week Rapid development Primitive streak formation 3rd germ layer formation Notochord Trilaminar embryo www.indiandentalacademy.com
  9. 9. 3rd week Prochordal plate Prochordal plate Head region Head region Hypoblast Hypoblast Primitive streak Primitive streak Tail region Tail region Epiblast Epiblast www.indiandentalacademy.com
  10. 10. Formation of notochord • Primitive streak • Primitive knot • Canalization of cord cells www.indiandentalacademy.com
  11. 11. Primitive streak and node www.indiandentalacademy.com
  12. 12. Migration of cells b/w hypoblast and epiblast www.indiandentalacademy.com
  13. 13. www.indiandentalacademy.com
  14. 14. www.indiandentalacademy.com
  15. 15. 3rd week – Notochord  Notochord is the structure around which the vertebral column forms  Developing notochord induces the overlying ectoderm to form neural plate www.indiandentalacademy.com
  16. 16. Neurulation • End of 3 week • Formation of neural tube and neural plate www.indiandentalacademy.com
  17. 17. Formation of neural tube www.indiandentalacademy.com
  18. 18. Neurulation www.indiandentalacademy.com
  19. 19. Neurulation www.indiandentalacademy.com
  20. 20. Neural crest cells • Ectomesenchymal in nature • Major source of connective tissue components, including cartilage, bone and ligaments of facial and oral region • Contribute to muscles and arteries of this region www.indiandentalacademy.com
  21. 21. • Ectomesenchymal tissue termed neural crest cells appears in the intermediate zone between the surface ectoderm and the neural tube during neurulation. www.indiandentalacademy.com
  22. 22. www.indiandentalacademy.com
  23. 23. Migraton is so excessive & their role is so imp Considered as fourth primary germ layer www.indiandentalacademy.com
  24. 24. Source and pattern of migration to the developing face and branchial arch system As they migrate from rhombomeres ,carry with them homeobox gene From the site. www.indiandentalacademy.com
  25. 25. Characteristics of neural crest cells. Pluripotent cells Migration Cyto-differentiation www.indiandentalacademy.com
  26. 26. Neural crest cells Connective tissue Muscles Derivatives Derivatives Pigment cells Nervous tissues ANS Sensory ganglia www.indiandentalacademy.com Endocrine tissues
  27. 27. Derivatives of neural crest cells. Connective tissue- Ectomesenchyme of facial prominences and branchial arches - Bones and cartilages of facial visceral skeleton www.indiandentalacademy.com
  28. 28. annotated_embryo.mov www.indiandentalacademy.com
  29. 29. -Dermis of face and neck -Stroma of salivary ,thymus thyroid,parathyroid and pituitary gland -Corneal mesenchyme -Aortic arch arteries www.indiandentalacademy.com
  30. 30. -Dental papilla -Portions of periodontal ligament ,Cementum Muscle tissue-Ciliary muscles -Covering connective tissue of branchial arch muscles www.indiandentalacademy.com
  31. 31. Nervous tissue-Leptomeninges. -Schwann sheath cells www.indiandentalacademy.com
  32. 32. Endocrine tissues • Adrenomedullary cells • carotid body www.indiandentalacademy.com
  33. 33. Pigment cells • Melanocytes in all tissues • Melanophores of iris www.indiandentalacademy.com
  34. 34. Neural crest cells Connective tissue Muscles Derivatives Derivatives Pigment cells Nervous tissues ANS Sensory ganglia www.indiandentalacademy.com Endocrine tissues
  35. 35. Sensory ganglia-Autonomic ganglia. -Spinal dorsal root ganglia. -Sensory ganglia. ANS-Sympathetic ganglia. -Parasympathetic ganglia. www.indiandentalacademy.com
  36. 36. Factors affecting migration • Extra cellular molecules: like fibronectin • Vitamin A,isotretinoin • 13 cis-retinoic acid • Mutant genes www.indiandentalacademy.com
  37. 37. Factors effecting the normal growth of neural crest derivatives • Number of cells leaving the neural tube • Rate of migration • Proportion of dividing • Minimal period between successive divisions • Number of cells that die www.indiandentalacademy.com
  38. 38. Characteristics of neural crest cells • Regulation www.indiandentalacademy.com
  39. 39. Significance of neural crest cells • In craniofacial region Differentiate to form most of the connective tissue of head ectomesenchyme www.indiandentalacademy.com
  40. 40. Significance in development of dentition • Neural crest is primary material for odontogenesis. • Interaction between neural crest, pharyngeal endoderm and oral ectoderm produces the dental lamina. • Neural crest provides material for dentin, pulp and cementum. www.indiandentalacademy.com
  41. 41. Altered Neural Crest Development • Mandibulofacial Dysostosis www.indiandentalacademy.com
  42. 42. • Hemifacial Microsomia www.indiandentalacademy.com
  43. 43. •Fetal alcohol syndrome • Due to deficiences of midline tissues of the neural plate ,caused by very high level of ethanol. www.indiandentalacademy.com
  44. 44. Branchial arches or pharyngeal arches www.indiandentalacademy.com
  45. 45. www.indiandentalacademy.com
  46. 46. Each pair of branchial arches contain a basic set of structure • Cartilage component • Muscular component • Vascular component • Nervous component www.indiandentalacademy.com
  47. 47. Branchial arches • Develops due to neural crest migration in the 4th week • Mesenchyme of each branchial arch gives rise to muscles, cartilages and bone www.indiandentalacademy.com
  48. 48. First branchial arch (mandibular arch) www.indiandentalacademy.com
  49. 49. 1st branchial arch Skeletal structures Skeletal structures Ligaments Ligaments Cartilage Cartilage MANDIBULAR ARCH MANDIBULAR ARCH Muscles Muscles Nerve Nerve www.indiandentalacademy.com
  50. 50. COMPONENTS OF 1st ARCH • Cartilage : MECKEL’S CARTILAGE --Arises 41st – 45th Day I.U --It provides a template for subsequent development of the mandible. www.indiandentalacademy.com
  51. 51. Structures formed by cartilaginous component www.indiandentalacademy.com
  52. 52. www.indiandentalacademy.com
  53. 53. www.indiandentalacademy.com
  54. 54. www.indiandentalacademy.com
  55. 55. Nerve supply www.indiandentalacademy.com
  56. 56. 2nd branchial arch Skeletal structures Skeletal structures Ligaments Ligaments Cartilage Cartilage HYOID ARCH HYOID ARCH Muscles Muscles Nerve Nerve www.indiandentalacademy.com
  57. 57. Second branchial arch (Hyoid Arch) Components: • Cartilage : Reichert’s Cartilage (45th – 48th I.U) -- Stapes -- Styloid process of the temporal bone. _ _Stylohyoid ligament. -- Lessor horn of sphenoid. -- Cranial part - Body of Hyoid. www.indiandentalacademy.com
  58. 58. www.indiandentalacademy.com
  59. 59. • Muscles : -- Stapedius -- Stylohyoid -- Post. Belly of Digastric -- auricular -- muscles of facial expression . www.indiandentalacademy.com
  60. 60. www.indiandentalacademy.com
  61. 61. • Nerve : -- Facial / VII Cranial nerve. -- Chorda tympani nerve (Ant 2/3rd of Tongue) Artery : -- Stapedial artery -- Transient i.e. disappears during fetal life www.indiandentalacademy.com
  62. 62. Nerve supply www.indiandentalacademy.com
  63. 63. 3rd branchial arch Greater cornu of hyoid Greater cornu of hyoid Lower part of body of hyoid Lower part of body of hyoid 3rd Arch 3rd Arch 9th CN 9th CN Stylopharyngeous Stylopharyngeous www.indiandentalacademy.com
  64. 64. 4th & 6th branchial arch Thyroid Thyroid Cricoid Cricoid Arytenoid Arytenoid Corniculate Corniculate Cunieform Cunieform 4TH & 6TH Arch 4TH & 6TH Arch Sup. Laryngeal N Sup. Laryngeal N Rec. Laryngeal N Rec. Laryngeal N cricothyroid cricothyroid constrictors of pharynx constrictors of pharynx Laryngeal muscles Laryngeal muscles www.indiandentalacademy.com
  65. 65. Ectodermal clefts Epi. Lining of ext. acoustic meatus Epi. Lining of ext. acoustic meatus Auricle Auricle www.indiandentalacademy.com
  66. 66. Ectodermal clefts Branchial cyst Branchial cyst Branchial sinus Branchial sinus www.indiandentalacademy.com
  67. 67. Endodermal pouches www.indiandentalacademy.com
  68. 68. www.indiandentalacademy.com
  69. 69. Branchial arch malformations • Branchial cyst • Branchial sinus • Branchial fistula www.indiandentalacademy.com
  70. 70. Thanx www.indiandentalacademy.com
  71. 71. Development of Tongue www.indiandentalacademy.com
  72. 72. Tongue www.indiandentalacademy.com
  73. 73. Tongue www.indiandentalacademy.com
  74. 74. www.indiandentalacademy.com
  75. 75. Tongue Papillae and taste buds • End of 8th week – vallate & foliate( 9th CN)???? Relation to terminal branches OF 9th CN www.indiandentalacademy.com
  76. 76. Tongue • Fungiform papillae – develop near termination of chorda tympani Filiform • Appear in early fetal life • No taste buds • Sensitive to touch www.indiandentalacademy.com
  77. 77. Tongue Nerve supply Vagus N Vagus N Glossopharyngeal N Glossopharyngeal N Lingual N Lingual N Chorda tympani Chorda tympani www.indiandentalacademy.com
  78. 78. Tongue Important points • 2nd branchial arch does not contribute to tongue formation Chorda tympani supplies fungiform papillae???? www.indiandentalacademy.com
  79. 79. Tongue www.indiandentalacademy.com
  80. 80. Tongue www.indiandentalacademy.com
  81. 81. Tongue www.indiandentalacademy.com Lymphatic drainage Lymphatic drainage
  82. 82. Tongue www.indiandentalacademy.com
  83. 83. Clinical correlation • Tongue tie • Macroglossia • Microglossia • Bifid tongue • Fissured tongue • Rhomboid tongue www.indiandentalacademy.com
  84. 84. Malformations of tongue Ankyloglossia Ankyloglossia www.indiandentalacademy.com
  85. 85. Malformations of tongue Fissured tongue Fissured tongue www.indiandentalacademy.com
  86. 86. Malformations of tongue Bifid tongue Bifid tongue www.indiandentalacademy.com
  87. 87. Malformations of tongue Median rhomboid glossitis Median rhomboid glossitis www.indiandentalacademy.com
  88. 88. Malformations of tongue Macroglossia Macroglossia www.indiandentalacademy.com
  89. 89. Malformations of tongue Hypertrophy of papillae Hypertrophy of papillae www.indiandentalacademy.com
  90. 90. Development of the face www.indiandentalacademy.com
  91. 91. • Face is derived from the following structures that lie around the stomatodaeum: • Frontonasal process • First pharyngeal arch www.indiandentalacademy.com
  92. 92. Facial prominences www.indiandentalacademy.com
  93. 93. www.indiandentalacademy.com
  94. 94. www.indiandentalacademy.com
  95. 95. www.indiandentalacademy.com
  96. 96. www.indiandentalacademy.com
  97. 97. Upper lip maxillary process with medial & lateral nasal process Frontonasal process becomes narrow Lower lip and jaw Mand. Prominences www.indiandentalacademy.com
  98. 98. Nose medial & lateral nasal process (rt & lt) Eye lens placode www.indiandentalacademy.com
  99. 99. • Dev. Of the face starts at the end of 4 week www.indiandentalacademy.com
  100. 100. www.indiandentalacademy.com
  101. 101. www.indiandentalacademy.com
  102. 102. www.indiandentalacademy.com
  103. 103. Facial Malformations www.indiandentalacademy.com
  104. 104. Facial Malformations www.indiandentalacademy.com
  105. 105. Facial Malformations www.indiandentalacademy.com
  106. 106. Facial Malformations www.indiandentalacademy.com
  107. 107. References • The Developing Human - Keith L Moore • Craniofacial Embryology G.H.Sperber • Human Embryology - I.B.Singh • Color Atlas of Oral Path - Robinson, Miller www.indiandentalacademy.com
  108. 108. Thank you For more details please visit www.indiandentalacademy.com www.indiandentalacademy.com

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