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GENES -Oncogenes in oral
cancer genesis
INDIAN DENTAL ACADEMY
Leader in continuing dental education
www.indiandentalacadem...
www.indiandentalacademy.com
www.indiandentalacademy.com
www.indiandentalacademy.com
www.indiandentalacademy.com
Head and neck cancer
Dominant - the genes have been
termed proto-oncogenes.
Recessive – the genes variously termed
anti-on...
Definition
Proto-oncogenes are normal cellular
genes that are involved in the control of
cell proliferation or differentia...
www.indiandentalacademy.com
Definition
Oncogene is a sequence of
deoxyribonucleic acid that has been
altered or mutated from its original form,
the pr...
www.indiandentalacademy.com
www.indiandentalacademy.com
www.indiandentalacademy.com
NOMENCLATURE

www.indiandentalacademy.com
Oncoproteins
Oncogenes encode proteins called
oncoproteins which resemble the normal
products of the proto-oncogenes with
...
www.indiandentalacademy.com
DISCOVERY

www.indiandentalacademy.com
Mechanism of oncogene activation
Viruses
Point mutations
Chromosome rearrangements
Gene amplifications

www.indiandentalac...
www.indiandentalacademy.com
www.indiandentalacademy.com
Point mutation

www.indiandentalacademy.com
Chromosomal rearrangement

www.indiandentalacademy.com
Gene amplification

www.indiandentalacademy.com
Gene amplification

www.indiandentalacademy.com
Types of oncogenes

www.indiandentalacademy.com
www.indiandentalacademy.com
www.indiandentalacademy.com
Growth factors

www.indiandentalacademy.com
Growth factor receptors

www.indiandentalacademy.com
www.indiandentalacademy.com
Signal transducers

www.indiandentalacademy.com
Transcription factors

www.indiandentalacademy.com
Transcription factors

www.indiandentalacademy.com
Cell death regulators

www.indiandentalacademy.com
Cell death regulators

www.indiandentalacademy.com
Cell cycle

www.indiandentalacademy.com
www.indiandentalacademy.com
Oncogenes in oral cancer

www.indiandentalacademy.com
c-myc

www.indiandentalacademy.com
myc

www.indiandentalacademy.com
c-myc
High metastatic potential
Poor response to chemotherapy

www.indiandentalacademy.com
ras family
• Four classes
–

H-ras

–

Ka-ras

–

Kb-ras

–

N-ras

www.indiandentalacademy.com
ras family

www.indiandentalacademy.com
EGFR family
– erb2

www.indiandentalacademy.com
erb2 in oral cancer
Overexpression –
poorly differentiated carcinomas,
lymph node metastasis,
shortened survival period

w...
Cyclin D1

www.indiandentalacademy.com
www.indiandentalacademy.com
Additional oncogenes in oral cancer
Ets1
Wt
pin
Bcl1 – int2 – hst – amplicon unit
Amplification – aggressiveness -Regional...
Anti-oncogenes
P53
Rb
P16
FHIT

www.indiandentalacademy.com
www.indiandentalacademy.com
Thank
you

www.indiandentalacademy.com
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Genes oncogenes in oral cancer genesis /certified fixed orthodontic courses by Indian dental academy

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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.

Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078

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Genes oncogenes in oral cancer genesis /certified fixed orthodontic courses by Indian dental academy

  1. 1. GENES -Oncogenes in oral cancer genesis INDIAN DENTAL ACADEMY Leader in continuing dental education www.indiandentalacademy.com www.indiandentalacademy.com
  2. 2. www.indiandentalacademy.com
  3. 3. www.indiandentalacademy.com
  4. 4. www.indiandentalacademy.com
  5. 5. www.indiandentalacademy.com
  6. 6. Head and neck cancer Dominant - the genes have been termed proto-oncogenes. Recessive – the genes variously termed anti-oncogenes. www.indiandentalacademy.com
  7. 7. Definition Proto-oncogenes are normal cellular genes that are involved in the control of cell proliferation or differentiation. www.indiandentalacademy.com
  8. 8. www.indiandentalacademy.com
  9. 9. Definition Oncogene is a sequence of deoxyribonucleic acid that has been altered or mutated from its original form, the proto-oncogene. www.indiandentalacademy.com
  10. 10. www.indiandentalacademy.com
  11. 11. www.indiandentalacademy.com
  12. 12. www.indiandentalacademy.com
  13. 13. NOMENCLATURE www.indiandentalacademy.com
  14. 14. Oncoproteins Oncogenes encode proteins called oncoproteins which resemble the normal products of the proto-oncogenes with exception that the, Oncoproteins are devoid of important regulatory elements and Their production does not depend on growth factors or external signals www.indiandentalacademy.com
  15. 15. www.indiandentalacademy.com
  16. 16. DISCOVERY www.indiandentalacademy.com
  17. 17. Mechanism of oncogene activation Viruses Point mutations Chromosome rearrangements Gene amplifications www.indiandentalacademy.com
  18. 18. www.indiandentalacademy.com
  19. 19. www.indiandentalacademy.com
  20. 20. Point mutation www.indiandentalacademy.com
  21. 21. Chromosomal rearrangement www.indiandentalacademy.com
  22. 22. Gene amplification www.indiandentalacademy.com
  23. 23. Gene amplification www.indiandentalacademy.com
  24. 24. Types of oncogenes www.indiandentalacademy.com
  25. 25. www.indiandentalacademy.com
  26. 26. www.indiandentalacademy.com
  27. 27. Growth factors www.indiandentalacademy.com
  28. 28. Growth factor receptors www.indiandentalacademy.com
  29. 29. www.indiandentalacademy.com
  30. 30. Signal transducers www.indiandentalacademy.com
  31. 31. Transcription factors www.indiandentalacademy.com
  32. 32. Transcription factors www.indiandentalacademy.com
  33. 33. Cell death regulators www.indiandentalacademy.com
  34. 34. Cell death regulators www.indiandentalacademy.com
  35. 35. Cell cycle www.indiandentalacademy.com
  36. 36. www.indiandentalacademy.com
  37. 37. Oncogenes in oral cancer www.indiandentalacademy.com
  38. 38. c-myc www.indiandentalacademy.com
  39. 39. myc www.indiandentalacademy.com
  40. 40. c-myc High metastatic potential Poor response to chemotherapy www.indiandentalacademy.com
  41. 41. ras family • Four classes – H-ras – Ka-ras – Kb-ras – N-ras www.indiandentalacademy.com
  42. 42. ras family www.indiandentalacademy.com
  43. 43. EGFR family – erb2 www.indiandentalacademy.com
  44. 44. erb2 in oral cancer Overexpression – poorly differentiated carcinomas, lymph node metastasis, shortened survival period www.indiandentalacademy.com
  45. 45. Cyclin D1 www.indiandentalacademy.com
  46. 46. www.indiandentalacademy.com
  47. 47. Additional oncogenes in oral cancer Ets1 Wt pin Bcl1 – int2 – hst – amplicon unit Amplification – aggressiveness -Regional nodal involvement Eiaf – ets1 family – increased MMP’sinvasive potential www.indiandentalacademy.com
  48. 48. Anti-oncogenes P53 Rb P16 FHIT www.indiandentalacademy.com
  49. 49. www.indiandentalacademy.com
  50. 50. Thank you www.indiandentalacademy.com

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