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Immune
Disorders

www.indiandentalacademy.com
INDIAN DENTAL ACADEMY
Leader in continuing dental education
www.indiandentalacademy.com

www.indiandentalacademy.com
“You can't fly a kite unless you go
against the wind and have a weight to
keep it from turning somersaults. The
same with ...
Introduction:
• Humoral Immunity
– B lymphocytes - Antibody

• Cell mediated Immunity
– T lymphocytes – Macrophages

• Non...
Introduction:
•
•
•
•
•

Immunity is not inherited.
Antigen / Antibody
Active / Passive immunity.
Vaccine, Toxoid, Live/Ki...
Immune Disorders:
• Immunodeficiency disorders
– AIDS, antibody deficiency

• Hypersensitivity Disorders (allergy)
– Type-...
Rheumatic fever:
•
•
•

Autoimmune disorder.
Group A, streptococcal pharyngitis.
Antibody cross react with connective tiss...
Morphology:
• Acute Rheumatic Fever –
–
–
–
–
–

Acute Inflammatory Phase
Heart – Pancarditis
Skin – Erythema Marginatum
C...
Acute Rheumatic vegetations:

www.indiandentalacademy.com
Acute Rheumatic vegetations:

www.indiandentalacademy.com
Fish mouth Mitral stenosis:

www.indiandentalacademy.com
What is Asthma?
•
•
•
•
•
•
•

Hypersensitivity – Allergy , Type I
of airways of lungs - Bronchi
Allergens – in the air, m...
Pathogenesis - Atopic Asthma:

www.indiandentalacademy.com
Asthma
Mechanism:
• Allergy
• Inflammation Of
Bronchi
• Obstruction
• Mucous Plugs

www.indiandentalacademy.com
INFLAMMATION

INDUCERS
Allergens,pollutants

Airway
Hyperresponsiveness
Genetic*

Airflow Limitation

TRIGGERS
Exercise
Co...
Epidemiology/pathology

Normal

Asthma

Barnes PJ

www.indiandentalacademy.com
Lung in Asthma with Mucous plugs

www.indiandentalacademy.com
Mucous plug in asthma:

www.indiandentalacademy.com
Asthma Microscopic Pathology
Obstructed
Inflammed
Bronchi

www.indiandentalacademy.com
Asthma - Bronchial morphology
•
•
•
•

inflammation
Eosinophils
Gland hyperplasia
Mucous plug in
lumen
• Hypertrophy of
mu...
Summary:
•
•
•
•
•
•
•
•

Not inherited…! Learns self – then Foreign.
Immune system – Humoral, Cell Med, Non-sp
Antigen & ...
"If you tell the truth, you have
infinite power supporting you;
but if not, you have infinite
power against you….!"
--Char...
www.indiandentalacademy.com
Leader in continuing dental education

www.indiandentalacademy.com
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IMMUNE DISORDERS /certified fixed orthodontic courses by Indian dental academy

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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.

Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078

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IMMUNE DISORDERS /certified fixed orthodontic courses by Indian dental academy

  1. 1. Immune Disorders www.indiandentalacademy.com
  2. 2. INDIAN DENTAL ACADEMY Leader in continuing dental education www.indiandentalacademy.com www.indiandentalacademy.com
  3. 3. “You can't fly a kite unless you go against the wind and have a weight to keep it from turning somersaults. The same with man. No man will succeed unless he is ready to face and overcome difficulties and is prepared to assume responsibilities” -- William J. H. Boetcker www.indiandentalacademy.com
  4. 4. Introduction: • Humoral Immunity – B lymphocytes - Antibody • Cell mediated Immunity – T lymphocytes – Macrophages • Non-Specific immunity – Neutrophils, Macrophages www.indiandentalacademy.com
  5. 5. Introduction: • • • • • Immunity is not inherited. Antigen / Antibody Active / Passive immunity. Vaccine, Toxoid, Live/Killed Primary response – slow, weak. – Learning period, memory cells. • Secondary response – rapid, strong www.indiandentalacademy.com
  6. 6. Immune Disorders: • Immunodeficiency disorders – AIDS, antibody deficiency • Hypersensitivity Disorders (allergy) – Type-I (IgE), II-IgG, IIIImmunecomplex, IV-Cell mediated. • Autoimmune disorders – SLE, Rhematoid, Rheumatic fever. www.indiandentalacademy.com
  7. 7. Rheumatic fever: • • • Autoimmune disorder. Group A, streptococcal pharyngitis. Antibody cross react with connective tissue in - susceptible individuals* • 2-3 weeks – Autoimmune reaction. • Inflammation - T lymphocytes, macrophages. • Heart, skin, brain & joints. www.indiandentalacademy.com
  8. 8. Morphology: • Acute Rheumatic Fever – – – – – – Acute Inflammatory Phase Heart – Pancarditis Skin – Erythema Marginatum CNS – Sydenham Chorea Migratory polyarthritis • Chronic Rheumatic Fever – Deforming fibrotic valvular disease. www.indiandentalacademy.com
  9. 9. Acute Rheumatic vegetations: www.indiandentalacademy.com
  10. 10. Acute Rheumatic vegetations: www.indiandentalacademy.com
  11. 11. Fish mouth Mitral stenosis: www.indiandentalacademy.com
  12. 12. What is Asthma? • • • • • • • Hypersensitivity – Allergy , Type I of airways of lungs - Bronchi Allergens – in the air, mast cell - IgE ab. Inflammation of airways – Bronchitis. Genetic, Environmental, Race, Age. High in industrial cities 4-19%, Fiji < 1% Increasing incidence …! www.indiandentalacademy.com
  13. 13. Pathogenesis - Atopic Asthma: www.indiandentalacademy.com
  14. 14. Asthma Mechanism: • Allergy • Inflammation Of Bronchi • Obstruction • Mucous Plugs www.indiandentalacademy.com
  15. 15. INFLAMMATION INDUCERS Allergens,pollutants Airway Hyperresponsiveness Genetic* Airflow Limitation TRIGGERS Exercise Cold Air, diseases, www.indiandentalacademy.com
  16. 16. Epidemiology/pathology Normal Asthma Barnes PJ www.indiandentalacademy.com
  17. 17. Lung in Asthma with Mucous plugs www.indiandentalacademy.com
  18. 18. Mucous plug in asthma: www.indiandentalacademy.com
  19. 19. Asthma Microscopic Pathology Obstructed Inflammed Bronchi www.indiandentalacademy.com
  20. 20. Asthma - Bronchial morphology • • • • inflammation Eosinophils Gland hyperplasia Mucous plug in lumen • Hypertrophy of muscle layer www.indiandentalacademy.com
  21. 21. Summary: • • • • • • • • Not inherited…! Learns self – then Foreign. Immune system – Humoral, Cell Med, Non-sp Antigen & Antibody – Complement/phagocyt. Primary & Secondary Response (slow/rapid) Acitve & Passive immunity Vaccine/Toxoid/Live/Killed/antisera. Immunodeficiency/Hypersensitivity/Autoimm Allergy,Asthma, Rheumatic fever, SLE, AIDS www.indiandentalacademy.com
  22. 22. "If you tell the truth, you have infinite power supporting you; but if not, you have infinite power against you….!" --Charles Gordon www.indiandentalacademy.com
  23. 23. www.indiandentalacademy.com Leader in continuing dental education www.indiandentalacademy.com

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