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Cellular injury and ageing /certified fixed orthodontic courses by Indian dental academy

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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.

Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078

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Cellular injury and ageing /certified fixed orthodontic courses by Indian dental academy

  1. 1. Cellular Injury & Ageing www.indiandentalacademy.com
  2. 2. Cell Injury: INDIAN DENTAL ACADEMY Leader in continuing dental education www.indiandentalacademy.com www.indiandentalacademy.com Shashi Mar-03
  3. 3. Cell Injury: Disease     Dis + Ease = Disease. “Discomfort due to Structural or functional abnormality” Disease is caused by an agent. Causes (etiology) can be   External / Environmental. E.g.. Heat, Bacteria. Internal E.g. stress, genes, ageing. www.indiandentalacademy.com Shashi Mar-03
  4. 4. Cell Injury: Cellular Injury & Adaptation:     Normal cell is in a steady state “Homeostasis” Change in Homeostasis due to stimuli Injury Injury - Reversible / Irreversible Adaptation / cell death www.indiandentalacademy.com Shashi Mar-03
  5. 5. Cell Injury: Response to Injury: Adaptations (reversible)        Hydropic degeneration Hypertrophy Hyperplasia Atrophy Accumulations - hyaline, fat, etc. Necrosis (irreversible) – cell death. www.indiandentalacademy.com Shashi Mar-03
  6. 6. Cell Injury: Terminology:    Necrosis: Morphologic changes seen in dead cells within living tissue. Autolysis: Dissolution of dead cells by the cells own digestive enzymes. (not seen) Apoptosis: Programmed cell death. Physiological, for cell regulation. www.indiandentalacademy.com Shashi Mar-03
  7. 7. Cell Injury: Types of Necrosis:     Coagulative – Eg. Infarction Liquifactive - Brain, abscess Caseous - Bacterial / Tuberculosis Gangrene - With infection www.indiandentalacademy.com Shashi Mar-03
  8. 8. Cell Injury: Sequels of Necrosis:      Cell Death Necrosis Autolysis Phagocytosis Organization & fibrous repair. www.indiandentalacademy.com Shashi Mar-03
  9. 9. Cell Injury: Hydropic change in ischemic - kidney Microvilli www.indiandentalacademy.com Shashi Mar-03
  10. 10. Cell Injury: Cerebral atrophy - Alzheimers: www.indiandentalacademy.com Shashi Mar-03
  11. 11. Cell Injury: Heart hypertrophy in hypertension: Left Ventricle www.indiandentalacademy.com Shashi Mar-03
  12. 12. Cell Injury: Muscle ischemic atrophy: www.indiandentalacademy.com Shashi Mar-03
  13. 13. Cell Injury: Extensive Caseous necrosis Tuberculosis www.indiandentalacademy.com Shashi Mar-03
  14. 14. Cell Injury: Caseous necrosis - Tuberculosis www.indiandentalacademy.com Shashi Mar-03
  15. 15. Cell Injury: Gangrene - Amputated Diabetic foot www.indiandentalacademy.com Shashi Mar-03
  16. 16. Cell Injury: Gangrene Intestine - Thrombosis. www.indiandentalacademy.com Shashi Mar-03
  17. 17. Cell Injury: Stroke- Liquifactive necrosis www.indiandentalacademy.com Shashi Mar-03
  18. 18. Cell Injury: Liver abscess: Liquifactive necrosis www.indiandentalacademy.com Shashi Mar-03
  19. 19. Cell Injury: Renal Infarction - Coagulative www.indiandentalacademy.com Shashi Mar-03
  20. 20. Cell Injury: Splenic Infarction - Coagulative necrosis www.indiandentalacademy.com Shashi Mar-03
  21. 21. Cell Injury: Infarction - Adrenal gland: www.indiandentalacademy.com Shashi Mar-03
  22. 22. Ageing www.indiandentalacademy.com
  23. 23. Cell Injury: Ageing: “Progressive time related loss of structural and functional capacity of cells leading to death”   Senescence, Senility, Senile changes. Ageing of a person is intimately related to cellular ageing. www.indiandentalacademy.com Shashi Mar-03
  24. 24. Cell Injury: Factors affecting Ageing:      Genetic – Clock genes, (fibroblasts) Diet – malnutrition, obesity etc. Social conditions Diseases – Atherosclerosis, diabetes etc. Werner’s syndrome. www.indiandentalacademy.com Shashi Mar-03
  25. 25. Cellular mechanisms of ageing Cell Injury:       Cross linking proteins & DNA. Accumulation of toxic byproducts. Ageing genes. Loss of repair mechanism. Free radicle injury Telomerase shortening. www.indiandentalacademy.com Shashi Mar-03
  26. 26. Cell Injury: Telomerase in ageing: Germ Cells Somatic Cells www.indiandentalacademy.com Shashi Mar-03
  27. 27. Cell Injury: Ageing –changes:        Gradual atrophy of tissues and organs. Dementia Loss of skin elasticity Greying and Loss of hair BV damage – atherosclerosis/bruising. Loss of Lens elasticity  opacity  vision Lipofuscin pigment deposition – Brown atrophy in vital organs. www.indiandentalacademy.com Shashi Mar-03
  28. 28. Cell Injury: Pathology of elderly www.indiandentalacademy.com Shashi Mar-03
  29. 29. Cell Injury: Factors affecting ageing:      Stress Infections Diseases Malnutrition Accidents    Diminished stress response. Diminished immune response. Good health. www.indiandentalacademy.com Shashi Mar-03
  30. 30. Cell Injury: Conclusions: Cellular Injury - Various causes Reversible Injury  Adaptations     Irreversible Injury - Necrosis    Hypertrophy, Hyperplasia, Atrophy Accumulations - Hydropic, hyaline, fat.. Coagulative, Liquifactive, Caseous Ageing - Causes, Changes, Factors www.indiandentalacademy.com Shashi Mar-03
  31. 31. Cell Injury: "No matter how dark things seem to be or actually are, raise your sights and see the possibilities – always see them, for they're always there.“ – Norman Vincent Peale www.indiandentalacademy.com Shashi Mar-03
  32. 32. Cell Injury: www.indiandentalacademy.com Leader in continuing dental education www.indiandentalacademy.com Shashi Mar-03

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