Aims: Flowers of Tagetes erecta (Et E) is considered to be effective in the treatment of epilepsy reported in Ayurveda, but the phytoconstituents present in Et E devoid of antiepileptic activity, but found with phytoconstituets which decrease seizure thresholds. Thus the work undertaken to evaluate the effect of ethanolic extract on epilepsy using in vivo models.Methods and Material: Et E was evaluated using the in vivo models such as pentobarbitone induced sleeping time, MES and PTZ induced convulsions , potentiation of PTZ induced convulsion, spontaneous locomotor activity, forced swim test, learned helplessness test and brewers yeast induced pyrexia model.Results: Present study revealed that extract is devoid of sedative, antiepileptic, proconvulsant activity. The Et E shown CNS stimulant activity, antidepressant and antipyretic activity. Conclusions: The findings suggested that ethanolic extract may reduce the seizure threshold in epileptic patients,chances of seizure precipitation is more, thus usage in epilepsy is cautious.
Keywords: Tagetes erecta, epilepsy, antiepileptic, antidepressant, CNS stimulant