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Diabetes

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Brief overview about Diabetes Mellitus, with Arabic terms..

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Diabetes

  1. 1. الداء السكري Diabetes mellitus قراءة سريعة Quick review الزملاء : محمد النعسان - مضر شالاتي - مصطفى دا و د http://groups.yahoo.com/group/aleppopharmacy16/
  2. 2. <ul><li>What’s Diabetes? </li></ul><ul><li>Symptoms </li></ul><ul><li>Causes </li></ul><ul><li>Diabetes Pathophysiology </li></ul><ul><li>Types of Diabetes </li></ul><ul><li>Cure and Therapy </li></ul><ul><li>Complications </li></ul><ul><li>Anti-Diabetic Drugs </li></ul>http://groups.yahoo.com/group/aleppopharmacy16/ Headlines
  3. 3. Definition Diabetes: is abnormal elevation in BLOOD glucose >126 mg%
  4. 4. الأعراض Symptoms Polyuria البوالة Polydipsia العطاش polyphagia الجوع http://groups.yahoo.com/group/aleppopharmacy16/
  5. 5. ماه ي أسباب الداء السكري؟ http://groups.yahoo.com/group/aleppopharmacy16/ نسبة السكر عالية في الدم انخفاض إفراز الإنسولين مقاومة لتأثير الإنسولين
  6. 6. Types of Diabetes أنواع الداء السكري Type 1 Type 2 Gestational diabetes Autoimmune destruction of the pancreatic beta cells. Insulin resistance -> high amounts of insulin -> beta cells are unable. The hormones of pregnancy can cause insulin resistance. http://groups.yahoo.com/group/aleppopharmacy16/
  7. 7. Glucose Absorption and Insulin Function امتصاص الغلوكوز ووظيفة الإنسولين Blood stream Tissues <ul><li>Stomach converts the food to glucose, then the glucose inter the blood stream and the pancreas respond and secrete insulin. </li></ul>Insulin Glucose http://groups.yahoo.com/group/aleppopharmacy16/
  8. 8. Glucose Absorption and Insulin Function امتصاص الغلوكوز ووظيفة الإنسولين Blood stream Tissues <ul><li>Stomach converts the food to glucose, then the glucose inter the blood stream and the pancreas respond and secrete insulin. </li></ul>Insulin Glucose http://groups.yahoo.com/group/aleppopharmacy16/ Diabetes Type 1: Destruction of β - Cells— < NO INSULIN
  9. 9. Glucose Absorption and Insulin Function امتصاص الغلوكوز ووظيفة الإنسولين Blood stream Tissues <ul><li>Stomach converts the food to glucose, then the glucose inter the blood stream and the pancreas respond and secrete insulin. </li></ul>Insulin Glucose http://groups.yahoo.com/group/aleppopharmacy16/ Diabetes Type 2: Resistance to insulin’s effect!
  10. 10. Cure and Therapy المداواة والعلاج Type 1 Type 2 Gestational diabetes only with injected insulin . (although dietary) combination of dietary treatment, tablets and injections resolves with delivery of the child http://groups.yahoo.com/group/aleppopharmacy16/ Chronic conditions
  11. 11. Complications المضاعفات <ul><li>“ may occur if the disease is not adequately controlled” </li></ul><ul><li>Hypoglycemia. </li></ul><ul><li>DKA. </li></ul><ul><li>“ Diabetic ketoacidosis” </li></ul><ul><li>Coma. </li></ul><ul><li>Cardiovascular diseases. </li></ul><ul><li>Renal failure. </li></ul><ul><li>Retinal damage. </li></ul><ul><li>Nerve damage. </li></ul><ul><li>Poor healing of wounds -> gangrene . </li></ul>http://groups.yahoo.com/group/aleppopharmacy16/ Acute حادة Chronic مزمنة
  12. 12. Anti-diabetic Drugs مضادات السكري <ul><li>Biguanides (Metformin). </li></ul><ul><li>Thiazolidinedions. (TZDs) </li></ul><ul><li>Rosiglitazone, Pioglitazone, Troglitazone. </li></ul><ul><li>Sulphonyl Ureas. </li></ul><ul><li>Glipizide, Gliclazide, Glibenclamide, Gliquidone. </li></ul><ul><li>α -Glucosidase Inhibitors. </li></ul><ul><li>Acarbose, Miglitol. </li></ul><ul><li>Insulin . </li></ul>http://groups.yahoo.com/group/aleppopharmacy16/
  13. 13. Mechanism of Action of TZDs nucleus http://groups.yahoo.com/group/aleppopharmacy16/ Cell proteins that decrease insulin resistance PPAR TZD
  14. 14. Mechanism of Action of Sulphonyl Urea Ca 2+ Sulphonyl urea K + K-Channel Blood stream Pancreas http://groups.yahoo.com/group/aleppopharmacy16/ β-Cell Ca-Channel Insulin
  15. 15. Mechanism of Action of alpha -Glucosidase Inhibitors Blood stream Intestinal Cell Glucose http://groups.yahoo.com/group/aleppopharmacy16/ Polysaccharides α -glucosidase absorption acarbose
  16. 16. The End عمل الزملاء : مصطفى داود، محمد النعسان، مضر شالاتي الفئة الخامسة إشراف : أ . حازم عقاد د . أيمن نعال

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