Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Sistemātiskā sarkanā vilkēde

1,967 views

Published on

Imunoloģijā

Published in: Health & Medicine
  • Be the first to comment

  • Be the first to like this

Sistemātiskā sarkanā vilkēde

  1. 1. Sistemātiskā sarkanā vilkēde Systemic Lupus Erythematosus (SLE) Ilga Grīnberga MF IV 2012.g.
  2. 2. SLEHroniska, multisistēmiska, iekaisuma slimība, kurai ir autoimuniloģiska etioloģija. *1,2+ 1)http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/systemic_lupu s_erythematosus_sle.html 2)http://www.medscape.com/public/mobileapp http://animalsspecies.blogspot.com/2011/02/gray-wolf-wolves-are-one-species-of-dog.html
  3. 3. Sastopamība• No visiem gadījumiem 70 - 90% ir sievietēm (parasti fertilā vecumā) [1]• Biežāk Afroamerikāņiem un Āziešiem nekā Eiropiešiem *1,2+• ASV 5,1:100’000 *2+ 1)http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/sy temic_lupus_erythematosus_sle.html 2)http://www.medscape.com/public/mobileapp
  4. 4. Imunopatoģenēze http://emedicine.medscape.com/article/332244-overview#a0104
  5. 5. Etioloģija• Vismaz 35 gēni ir saistīti ar SLE• Biezāk sastopami leikocītu antigēni: HLA-A1, B8, DR3• Arī komplimentu deficīts ( biežāk C4, C2)• Biežāk EBV nēsātājiem• Zems D vitamīna līmenis 1)http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/sy temic_lupus_erythematosus_sle.html 2)http://www.medscape.com/public/mobileapp
  6. 6. Klīniskās pazīmes*a+• Biežāk simptomu triāde – Drudzis – Izsitumi – Locītavu sāpes *1,2+ 1)http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/sy temic_lupus_erythematosus_sle.html 2)http://www.medscape.com/public/mobileapp
  7. 7. Tauriņveida izsitumi http://emedicine.medscape.com/article/332244-treatment
  8. 8. Eritrēma http://emedicine.medscape.com/article/332244-treatment
  9. 9. Locītavu sāpes http://www.diyhealth.com/lupus-symptoms.html
  10. 10. Klīniskās pazīmes*b+Bet var izpausties arī citās sistēmās: – Muskuloskelitārā – Dermaoloģiskā – Renālā – Kardiopulmonālā – Gastrointestinālā – Hematologiskā [1,2] 1)http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/sy temic_lupus_erythematosus_sle.html 2)http://www.medscape.com/public/mobileapp
  11. 11. Diagnostika• Klīniskie kritēriji• Citopēnijas• Autoantivielas http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/syst emic_lupus_erythematosus_sle.html
  12. 12. Criteria for the Classification of SLE*At least 4 of the following are required to classify patients as having SLE in reports of clinical research:• Malar rash• Discoid rash• Photosensitivity• Oral ulcers• Arthritis• Serositis• Renal disorder• Leukopenia (< 4000/μL), lymphopenia (< 1500/μL), hemolytic anemia, or thrombocytopenia (< 100,000/μL)• Neurologic disorder• Positive test for anti-DNA, anti-Smith, or antiphospholipid antibodies• Antinuclear antibodies in high titers*These 11 criteria are from the American College of Rheumatology and are also often used as aids in diagnosis. Although at least 4 criteria are not needed to make a diagnosis of SLE, the criteria help in recognizing manifestations of SLE. http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/syst emic_lupus_erythematosus_sle.html
  13. 13. Terapijas principi• NPIL• Pret malārijas medikamenti (vieglai formai) – Hydroxychloroquine 200 mg po 1xdienā• Kortikosterioīdi – Prednisone 40-60 mg po 1xdienā• Imūnsupresanti http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/syst emic_lupus_erythematosus_sle.html
  14. 14. Prognoze• SLE ir hroniska, recidivējoša un neparedzama• Remisija var ilgt gadiem• 10 gadu dzīvildze attīstītajās valstīs ir >95%• Ātra diagnoze paildzina dzīvildzi• Medikamentu dēļ pieaug osteoporozes un KSS risks. http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/syst emic_lupus_erythematosus_sle.html
  15. 15. Paldies par uzmanību! http://www.petandwildlife.com/wolves/wolf_species.htm

×