Products refresher webinar - Igennus

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Products refresher training webinar, with Sophie Tully BSc MSc, Wednesday 29th January

In this training webinar, Education Manager Sophie Tully takes you through each of the therapeutic Igennus products and the key points for recommending them to clients to help refresh your memory, offering fresh research, understanding and clinical tools.

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  • 100,000 years ago
  • Betaine and homocysteineHomocysteine can be converted back to methionine independent of the The folate cycle via betaine and it is often considered alongside folic acid, vitamin B6 and vitamin B12 dietary intervention for managing homocysteineBetaine is, however, found widely in both plant and animals products and much of the body's betaine needs are actually met by choline oxidationHigh doses of 4–6 g/d betaine required to induce a favourable outcome on homocysteine levels have been shown in several randomised, placebo-controlled studies to increase total cholesterol, LDL cholesterol, and triglyceridesThe adverse effects on blood lipids may therefore undo the potential benefits for cardiovascular health of betaine supplementation through homocysteine lowering
  • Products refresher webinar - Igennus

    1. 1. Igennus Product Refresher Webinar
    2. 2. What is inflammation? • The normal response of a tissue to injury • Triggered by a number of causes including infection, invading pathogens (such as bacteria or viruses), trauma or compromised blood flow • Three defined phases: - Initiation - Resolution - Termination
    3. 3. Inflammatory response Resoleomics - the process of inflammation resolution Eicosanoid switch Stop signal Pro-inflammatory reduced LTB4 PGE2 Anti-inflammatory increased Time Initiation Resolution Termination
    4. 4. The role of diet in modulating inflammation Many modern food types are new in regard to human evolution Triggers from chronic altered diet and psycho-emotional stress negatively influence the resolution step of the inflammatory response Failure to resolve inflammation increases susceptibility to the development of chronic, low-grade, inflammation-based diseases due to the constant activation of both the HPA-axis and innate immune system Bosma-den Boer MM, van Wetten ML, Pruimboom L: Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering. Nutrition & metabolism 2012, 9:32.
    5. 5. The key to regulating inflammation is through the modulation of eicosanoids: ⁻ pro-inflammatory eicosanoids drive the immune and inflammatory processes ⁻ anti-inflammatory eicosanoids act to end the process through resolution Overproduction of pro-inflammatory products or reduced production of anti-inflammatory products can result in continued production of inflammatory products – the hallmark of silent inflammation
    6. 6. The role of lipid mediators • Pro-inflammatory lipid arachidonic acid (AA) • Anti-inflammatory/pro-resolving lipids dihomo-gamma-linolenic acid (DGLA) eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) • AA and EPA are the significant eicosanoid precursors • AA to EPA ratio is a direct biomarker of inflammatory status
    7. 7.
    8. 8. AA to EPA ratio is a direct measure of inflammation By modifying diet we can influence the ratio of pro-inflammatory (from AA) to anti-inflammatory eicosanoids (from EPA)
    9. 9. Conditions associated with a high AA to EPA ratio • • • • • • • • • Depression Bipolar disorder Schizophrenia Myalgic encephalomyelitis Fibromyalgia Chronic pain syndromes Diabetes Cardiovascular disease Cancer • Inflammatory disorders • Inflammatory bowel disease: (Crohn’s disease, ulcerative colitis) • Neurodevelopmental disorders: (autism, dyslexia, dyspraxia, ADHD) • Alzheimer’s disease • Huntington’s disease • Skin conditions: (eczema, psoriasis, dermatitis)
    10. 10. Shifting the balance ⁻ AA and EPA contents of cell membranes can be altered through consumption of omega-3 EPA (marine products/marine oils) ⁻ Changing the fatty acid composition of cell membranes affects • changes in membrane structure • products involved in immune function and the inflammatory cascade • cell signalling • gene expression and cell cycle
    11. 11. EPA as a therapeutic agent ⁻ Cod liver oil benefits to health long established ⁻ Key protective and beneficial aspects are the essential fatty acids: EPA and DHA ⁻ Only recently discovered, these two important EFAs have very different roles within the body ⁻ EPA = anti-inflammatory, immune function, neuron and brain function support ⁻ DHA = main structural fat for cells and brain development
    12. 12. EPA reduces the activity of AA in two ways • EPA (but not DHA) is an inhibitor of the enzyme delta-5-desaturase that produces AA • EPA also competes with AA for the enzyme PLA2 necessary to release AA from the membrane phospholipids Therapeutically, fish oils are not all equal
    13. 13. Restore & Maintain® treatment protocol
    14. 14. Pharmepa® Restore & Maintain™ anti-inflammatory protocol Restore with pure EPA 3-6 months Introduce GLA for long-term maintenance
    15. 15. • Igennus is the only independent manufacturer Step of specialist Fatty 1: Restore UK. Based in Acid in the Cambridge the medical innovation hub for the Pharmepa E-EPA 90 provides 1000 mg EPA with just two easy-to-swallow capsules daily. This product UK: provides a loading dose of super strength EPA and is Seven Seas for people whoPharma Germany with Merck have never supplemented ideal or those who have taken a break from Minami pure EPA EPA supplementation Canada Atrium Pharma omega-3 - Biocare - Eskimo 3 - Equizen Elder Pharma India Bringwell Pharma Sweden Vifor Pharma Swiss
    16. 16. • Igennus is theStep 2:independent manufacturer only Maintain Pharmepa E-EPA the UK. Based in of specialist Fatty Acid in80 combines 80% ethyl-EPA concentrate with GLA and Cambridge the medicalprimrose oiltriterpenes from organic innovation hub B5, D3the for & E virgin evening and vitamins UK: This product balances and maintains the omega-6 Seven Seas omega-3 ratio and is suitableGermany use Merck Pharma for long-term to Minami after supplementing PharmaEPA. Atrium with pure Canada Alternatively, long-term users of omega-3 Biocare supplements may Pharma and take step 2 as a Elder skip step 1 India Eskimo 3 maintenance supplement Bringwell Pharma Sweden - Equizen Vifor Pharma Swiss
    17. 17. Pharmepa® Restore & Maintain™ Benefits summary • Igennus is the only independent manufacturer  Allows high concentrations of EPA to be achieved  of specialist Fatty Acid in the UK. Based in Maintains DHA levels: • raises both the DHA levels DHA is needed) hub for the CambridgeEPA andmedical(ifinnovationthus improving index’ UK:'omega-3DHA loss from cell membranes • protects         Enhances mitochondrial function - Seven Seas Merck Pharma Germany Maintains cell integrity including neuronal systems - Minami Atrium Pharma Canada Counteracts inflammation/oxidative stress Powerful antidepressant - Biocare Elder Pharma India Improves immune function - Eskimo 3 Bringwell Pharma Sweden Prevents the death of healthy cells Induces 'programmed cell death' of damaged, genetically mutated cells - Equizen Vifor Pharma Swiss Improves cardiovascular function
    18. 18. Vegan therapeutic alternative?
    19. 19. Echiomega •• Igennus is theplantagineum Derived from Echium only independent manufacturer • of specialist Fatty Acid in the UK. Based in Echium seed oil is a novel food approved source of SDA and ALA • Cambridge theEPA SDA is the precursor to medical innovation hub for the UK: • • • • • 25-30% of SDA converts to EPA Merck Pharma Germany - Seven Seas 5-8% of ALA - Minami Atrium Pharma Canada Echiomega is naturally rich in SDA SDA directly increases cellular EPA levels - Biocare Elder Pharma India Echium seed oil provides standalone health benefits - Eskimo 3 - Equizen Bringwell Pharma Sweden Vifor Pharma Swiss
    20. 20. Echiomega • Igennus is the only independent manufacturer  Provides the building blocks to restore optimum of specialist Fatty Acid in the UK. Based in omega-3 and omega-6 levels  Favourable omega-6 tothe medical innovation hub for the omega-3 Cambridgeand GLA ratio of 1:1.8  Naturally high in SDA UK:  Vegetarian precursor to EPA      Supports immune function Merck Pharma Germany Naturally - Seven Seas anti-inflammatory Supports - Minami health cardiovascular Atrium Pharma Canada Lowers triglycerides Early studies show enhanced glycaemic control - Biocare Elder Pharma India and reduced atherosclerosis in animal models - Eskimo 3 - Equizen Bringwell Pharma Sweden Vifor Pharma Swiss
    21. 21. Nutritional co-therapeutics
    22. 22. Cardiovascular Mood health disorders Pharmepa® Homocysteine ControlTM VESIsorb® Ubiquinol Pharmepa® Homocysteine ControlTM Neurodevelopmental disorders Vegepa E-EPA 70 + Chewables NeurobalanceTM
    23. 23. Homocysteine ControlTM
    24. 24. Homocysteine ControlTM • Igennus is the only independent manufacturer folic acid, vitamin B6 and vitamin B12 of specialist Fatty Acid in the UK. Based in formulated to prevent and the medical innovation hub for the Cambridge reduce elevated plasma homocysteine UK: slow-release delivery system - Seven Seas Merck Pharma Germany most bioavailable forms of each ingredient - Minami Atrium Pharma Canada ensures optimal blood plasma levels are - Biocare Elder Pharma India maintained throughout the day - Eskimo 3 Bringwell Pharma Sweden - Equizen Vifor Pharma Swiss
    25. 25. Homocysteine ControlTM • Igennus is the only independent manufacturer of specialist Fatty Acid in the UK. Based in  Highly bioavailable Lowers homocysteine levels Cambridge the medical innovation hubnutrients for the  Easy-to-swallow tablets Supports cardiovascular function  Split-dosing for optimal bioavailability UK: Supports healthy mood  Sustained-release tablets for     Supports methylation pathways  Supports neurotransmitter metabolism  Supports red blood cell formation  Supports neurological function  Supports DNA and protein synthesis - Seven Seas - Minami - Biocare - Eskimo 3 - Equizen enhanced absorption & Merck Pharma Germanyoptimal tissue distribution  Offers benefits for cardiovascular Atrium Pharmabrain function and mood Canada health, balance Elder Pharma India Bringwell Pharma Sweden Vifor Pharma Swiss
    26. 26. Homocysteine clinical levels 0.0 – 15 mmol Desirable Optimal Critical 0 6.0 9.0 15+
    27. 27. Role and benefits of a healthy methylation cycle  Neurotransmitter production: o Mood o Memory o Learning o Gut function  Antioxidant activity: o Increased glutathione production o Reduced free radical production  Cardioprotection: o Reduced risk of cardiovascular disease and stroke  Detoxification: o Improved liver function o Increased energy o Improved sleep  Neuroprotection  Improves cell signalling  Anti-inflammatory  Normal cell cycle  Reduced risk of bone loss and fracture  Improved fertility  Anti-ageing
    28. 28. Therapeutic application for Homocysteine ControlTM  Cardiovascular disease o Heart attack o Stroke o Vascular disease o Atherosclerosis  Mood disorders o Depression o Schizophrenia o Bipolar syndrome  Neurodegenerative diseases o Huntington’s disease o Parkinson’s disease o Alzheimer’s disease  Neuromuscular diseases o Muscular dystrophy o Multiple sclerosis  Migraine  Cell cycle control  Diabetes  Liver disorders  Thyroid disease/low thyroid function  Infertility  Pregnancy complications  Macular degeneration  Chronic fatigue syndrome
    29. 29. Homocysteine ControlTM Nutritional information Serving size: 1 tablet Amount per tablet % RDA 8 mg 570% Vitamin B12 (as methylcobalamin) 300 µg 12,000% Folic acid 300 µg 150% Vitamin B6 (as pyridoxal-5-phosphate) Ingredients Bulking agent: calcium carbonate; emulsifier: microcrystalline cellulose; thickener: hydroxypropyl methylcellulose; vitamin B6 (pyridoxal-5-phosphate); anti-caking agents: magnesium stearate, stearic acid; folic acid; vitamin B12 (methylcobalamin); glycerol.
    30. 30. Neurobalance TM
    31. 31. NeurobalanceTM • magnesium, zinc and vitamin B6 • • • Igennus is the only independent manufacturer formulated to aid in normalFatty Acid in the UK. Based in of specialist neurotransmitter production and function Cambridge the medical innovation hub for the scientifically formulated supplement UK: • synergistic benefits to optimise the functioning of the - Seven Seas Merck Pharma nervous system • • Germany - Minami Atrium Pharma Canada slow-release delivery system ensures optimal blood - Biocare Elder the plasma nutrient levels are maintained throughout Pharma India day - Eskimo 3 Bringwell Pharma Sweden most bioavailable forms of each ingredient - Equizen Vifor Pharma Swiss
    32. 32. NeurobalanceTM       • Igennus is the only independent manufacturer of specialist Fatty Acid in the UK. Based in Cambridge Supports neurotransmitter the medical innovation hub for the  Highly bioavailable nutrients metabolism  Synergistic relationship between Mg UK: Supports neurological function and B6 Supports hormone balance Supports immune function Supports DNA and protein synthesis Aids in the production of sleep modulators  Supports a healthy mood  Anti-anxiety benefits - Seven Seas - Minami - Biocare - Eskimo 3 - Equizen  Easy-to-swallow tablets  Split-dosing for optimal bioavailability  Sustained-release tablets for enhanced absorption & optimal tissue distribution  Offers benefits for brain function and mood balance Merck Pharma Germany Atrium Pharma Canada Elder Pharma India Bringwell Pharma Sweden Vifor Pharma Swiss
    33. 33. Neurotransmitter Functions Dopamine Movement, memory, pleasurable, reward, behaviour, cognition, attention, inhibition of prolactin production, sleep, mood, learning Serotonin Mood, appetite, sleep, memory, learning, body temperature, pain Melatonin Libido, sleep, immune function Norepinephrine ‘Fight or flight’ response, attentiveness, mood, mental arousal, emotions, sleep, dreaming, learning Epinephrine ‘Fight or flight’ response, mental focus, attention GABA Muscle tone, sleep, anxiety modulator
    34. 34. Therapeutic application for Neurobalance  o o o o  o o o Neurodevelopmental disorders Attention-deficit hyperactivity-disorder (ADHD) Autistic spectrum disorders (ASD) Dyspraxia Dyslexia Mood disorders Depression Schizophrenia Bipolar syndrome  o o o Neurodegenerative diseases Huntington’s disease Parkinson’s disease Alzheimer’s disease  Women’s health o Premenstrual syndrome (PMS) o Menopausal symptoms
    35. 35. NeurobalanceTM Nutritional information Serving size: 2 tablets Amount per tablet % RDA Zinc methionine 14 mg 140 % Magnesium (elemental)* 60 mg 16 % Vitamin B6 (pyridoxal-5-phosphate) 10 mg 714% * from 376 mg magnesium citrate Ingredients Magnesium citrate; bulking agent: calcium carbonate; emulsifier: microcrystalline cellulose; zinc methionine; vitamin B6 (pyridoxal-5-phosphate); thickener: hydroxypropyl methylcellulose; anti-caking agents: stearic acid, silicon dioxide, magnesium stearate.
    36. 36. VESIsorb® Ubiquinol-QH
    37. 37. VESIsorb® Ubiquinol-QH • VESIsorb® Ubiquinol-QH • • • Igennus is the only independent manufacturer most bioavailable source of the activated form of of specialist Fatty Acid in the UK. Based in coenzyme Q10 (CoQ10) Cambridge the medical innovation hub for the patented VESIsorb® delivery system provides UK: colloidal, highly solubilised ubiquinol - Seven the water layer barrier in the gut Merck Pharma Germany • passes easily throughSeas and into the bloodstream - Minami Atrium Pharma Canada • unprecedented absorption - Biocare • • Elder Pharma India - Eskimo 3 Bringwell Pharma Sweden optimal blood CoQ10 levels - Equizen Vifor Pharma Swiss 1 a day provides therapeutic, sustained action
    38. 38. VESIsorb® Ubiquinol-QH • Igennus is the only independent manufacturer of specialist Fatty Acid in the UK. Based in  Energy production  Patented VESIsorb® delivery system Cambridge the medical innovation hub for the  Antioxidant activity  Mimics natural intestinal transport UK:  Cardioprotection  easily absorbed into the bloodstream for     Neuroprotection Anti-inflammatory Promotes thermogenesis Cellular communication & gene expression  Supports organ metabolism  Supports normal cell cycle - Seven Seas - Minami - Biocare - Eskimo 3 - Equizen optimal tissue distribution Pre-digested solubilised ubiquinol for faster absorption Reaches therapeutic plasma concentrations Sustained action Unprecedented bioavailability 1-a-day dosing  Merck Pharma Germany Atrium Pharma Canada  Elder  Pharma India   Bringwell Pharma Sweden Vifor Pharma Swiss
    39. 39. Coenzyme Q10 • CoQ10 is a powerful, fat-soluble, vitamin-like substance • Two main functions: • Energy production – cellular respiration • Antioxidant/antioxidant recycling • Two main forms • Ubiquinone – oxidised form • Ubiquinol – reduced form • 96% of CoQ10 within the body is in the form of ubiquinol • Ubiquinol is the active form of CoQ10
    40. 40. CoQ10 production and intake • Endogenous CoQ10 synthesis is a complex multi-step process • Tissue CoQ10 levels generally peak around the age of 20-30 and decline with age • The conversion of ubiquinone to ubiquinol also declines with age • Majority of dietary CoQ10 is in the form of ubiquinone • Found in foods such as fish, organ meats and germ of whole grains, the average diet is estimated to provide approximately 10 mg/day of CoQ10
    41. 41. Ubiquinol deficiency alters mitochondria function and lowers antioxidant status, leading to increased free radical generation Inflammation Lungs Free radical damage and oxidative stress Skin Ageing Cardiovascular Brain Immunity
    42. 42. Acetyl-CoA HMG-CoA synthase HMG-CoA HMG-CoA reductase inhibitors (statins) HMG-CoA reductase Mevalonate Cholesterol Coenzyme Q10 (ubiquinone)
    43. 43. • Absorption occurs in the small intestine directly into the lymphatic system followed by absorption into the bloodstream • Absorption is generally poor (large lipophilic molecule) and fat soluble molecules must cross the ‘unstirred’ water layer for effective uptake • ~60% of oral supplements may be excreted via the faeces • High variability with absorption depending on the dosage form • Highest bioavailability when taken with lipid-containing food
    44. 44. VESIsorb® technology • The aqueous diffusion layer or 'unstirred' water layer adjacent to the intestinal membrane has long been regarded as a potential barrier for intestinal absorption of compounds, especially large fat-soluble molecules • The task of naturally formed bile salt-mixed micelles, having a size <10 nm, is to transport the lipophilic molecules through the aqueous environment of the gastrointestinal tract and across the unstirred water layer to the absorptive epithelium • VESIsorb® is a novel delivery technology that mimics this natural absorption process to improve bioavailability of large lipophilic molecules
    45. 45. Plasma CoQ10 (mg/mL) 7.5 7 6.5 6 5.5 5 4.5 4 3.5 3 2.5 2 1.5 1 0.5 0 Cmax VESIsorb® delivered CoQ10 is absorbed FASTER, reaching concentrations that are STRONGER and stay in the body LONGER than generic delivery methods Therapeutic level VESIsorb® Tmax Oil-based 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Time (hours) 120mg single dose of VESIsorb® delivered CoQ10 reaches therapeutic levels within 2 hours, reaching maximum blood plasma levels (6.89 mg/mL) (Cmax) within around 4 hours (Tmax) In contrast, 120mg single dose of oil-based CoQ10 reaches maximum blood plasma levels (2.44 mg/mL) within 5 hours and fails to achieve therapeutic levels VESIsorb® increases the bioavailability of CoQ10 by 622%
    46. 46. VESIsorb® Ubiquinol-QH Nutritional information Serving size: 1 capsule Ubiquinol (Kaneka QH TM Amount per capsule – activated coenzyme Q10) Vitamin E ( α-tocopherol) 100 mg 6.7 mg α-TE* *56% EU RDA Ingredients Ubiquinol activated coenzyme Q10 (Kaneka-QH™); capsule shell (emulsifier: gelatine; glycerol: colour: caramel); medium chain triglycerides; emulsifiers: non-ionic surfactant, polyglycerol fatty acid esters; antioxidant: vitamin E.
    47. 47. Therapeutic applications for VESIsorb® Ubiquinol-QH  Cardiovascular disease o Cardiomyopathy o Congestive heart failure o Angina o Arrhythmias o Hypertension o Atherosclerosis  Neurodegenerative diseases o Huntington’s disease o Parkinson’s disease o Alzheimer’s disease  Neuromuscular diseases  Chronic fatigue syndrome             Statin-associated myopathy Mitochondrial disease Muscular dystrophy Chronic fatigue conditions Diabetes Cell cycle regulation Chronic obstructive pulmonary disease Migraine Immune disorders HIV/AIDS Periodontal disease Male infertility
    48. 48. • Igennus is the www.igennus.com only independent manufacturer 01223 421434 of specialist Fatty Acid in the UK. Based in info@igennus.com Cambridge the medical innovation hub for the UK: Sophie Tully Nutrition education manager - Seven Seas sophiet@igennus.com Merck Pharma Germany - Minami education@igennus.com Atrium Pharma Canada 07908683174 - Biocare Elder Pharma India - Eskimo 3 Bringwell Pharma Sweden - Equizen Vifor Pharma Swiss

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