Nutritional co-therapeutics
NeurobalanceTM
Neurobalance
Zinc, magnesium & vitamin B6

TM
Neurotransmission is the process by which
signalling molecules (neurotransmitters) are
released by a neuron (the presynapt...
Phenylalanine
L-tryptophan
Tyrosine
Acetyl-CoA

Choline

Glutamine

5-hydroxy
tryptophan
Dopa
Glutamate

Serotonin

Dopami...
Phenylalanine
L-tryptophan

Mg, Zn

Tyrosine
Acetyl-CoA
5-hydroxy
tryptophan

Choline

Glutamine

Mg, Zn

Dopa
Glutamate
M...
Neurotransmitter receptors and transporter proteins
 Neurotransmitters are required to bind to receptors to exert its
fun...
Zn, Mg and vitamin B6 for neurotransmission
 Zn, Mg and vitamin B6 play key roles in neurotransmitter
synthesis
 Zn and ...
NeurobalanceTM
 Magnesium (Mg), zinc (Zn) & vitamin B6 are key nutrients required for
both neurotransmitter synthesis and...
Neurodevelopmental disorders
 Evidence suggests a breakdown in several neurotransmitter pathways in
neurodevelopmental di...
Author

Intervention

Mousain-Bosc
et al, 2006

Mousain-Bosc
et al, 2004

Duration

n=

Assessment

Findings

magnesium8-w...
 Serum zinc levels have been found to be significantly lower in ADHD
children compared to controls
 Consumption of certa...
Author

Intervention

Duration

n=

Assessment

Findings

Arnold et al,
2011

13-40mg zinc
glycinate

52
(age 6-14)

DSM-I...
Neurodegenerative disease
 Nerve damage can occur as a consequence of dysregulated inflammation
or as a result of scarrin...
Women’s health
 Reduced levels of several essential nutrients, including Mg, zinc and vitamin
B6, are common in:
- women ...
NeurobalanceTM key features and benefits
Zinc methionine offers superior bioavailability,
antioxidant and immune-enhancing...
NeurobalanceTM
Nutritional information
Serving size: 2 tablets

Amount per tablet

% RDA

Zinc methionine

14 mg

140 %

M...
NeurobalanceTM
Directions for use
Children aged 4-8 years should take 2 tablets daily.
Children aged 9-15 years should tak...
NeurobalanceTM
NeurobalanceTM is a blend of magnesium, zinc and vitamin B6,
formulated to aid in normal neurotransmitter p...
ninab@igennus.com
www.igennus.com
drninabailey.co.uk
01223 421434
07527384229
Magnesium absorption
 Typical magnesium absorption:
40% of magnesium intake absorbed in the small intestine
5% absorbed i...
Mg citrate
Mg gluconate
Mg lactate

Decreasing
solubility

Mg carbonate
Mg oxalate
Mg hydroxide
Mg oxide
Neurobalance technical training webinar
Neurobalance technical training webinar
Neurobalance technical training webinar
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Neurobalance technical training webinar

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Neurotransmitters are chemicals that communicate information throughout the brain and body. Neurotransmitter synthesis is a complex process requiring the action of enzymes that are in turn dependent on the presence of specific vitamins and mineral co-factors. NeurobalanceTM is a blend of magnesium, zinc and vitamin B6, micronutrients essential to the production of serotonin, dopamine, adrenaline, noradrenaline and gamma-aminobutyric acid (GABA). This webinar will provides information relating to the therapeutic use of NeurobalanceTM and covers the following:

- A brief introduction to the Neurotransmission process
- The health implications of poor neurotransmission
- Therapeutic application of Neurobalance
- Mechanisms of action for Neurobalance
- Dosing guides for key health conditions and incorporation into protocols

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Neurobalance technical training webinar

  1. 1. Nutritional co-therapeutics NeurobalanceTM
  2. 2. Neurobalance Zinc, magnesium & vitamin B6 TM
  3. 3. Neurotransmission is the process by which signalling molecules (neurotransmitters) are released by a neuron (the presynaptic neuron), and bind to and activate the receptors of another neuron (the postsynaptic neuron); it can be defined by the following steps: 1. Synthesis of the neurotransmitter 2. Storage of the neurotransmitter (in storage granules or vesicles in the axon terminal) 3. Release of the neurotransmitter into the synaptic cleft occurs as a result of calcium influx into the axon terminal during an action potential 4. The neurotransmitter then binds to and activates a receptor in the postsynaptic membrane 5. The neurotransmitter is either destroyed enzymatically, or taken back into the terminal from which it came, where it can be reused, or degraded and removed
  4. 4. Phenylalanine L-tryptophan Tyrosine Acetyl-CoA Choline Glutamine 5-hydroxy tryptophan Dopa Glutamate Serotonin Dopamine Acetylcholine GABA Noradrenaline Melatonin Adrenaline
  5. 5. Phenylalanine L-tryptophan Mg, Zn Tyrosine Acetyl-CoA 5-hydroxy tryptophan Choline Glutamine Mg, Zn Dopa Glutamate Mg, Zn, B6 Zn, B6 Zn, B6 Zn, B6 Serotonin Dopamine Acetylcholine GABA Noradrenaline Melatonin Adrenaline
  6. 6. Neurotransmitter receptors and transporter proteins  Neurotransmitters are required to bind to receptors to exert its function  The physiological effect of the neurotransmitter is dependent not only on the activity of the receptor, but also ‘transporters’, membrane-spanning proteins that pump neurotransmitters out of the synapse back into the presynaptic cell, and into vesicles for later storage and release  The transporter protein, by recycling, regulates its concentration in the synapse, and thus its effects on the receiving neurone
  7. 7. Zn, Mg and vitamin B6 for neurotransmission  Zn, Mg and vitamin B6 play key roles in neurotransmitter synthesis  Zn and Mg play a role as neuromodulators by affecting the function of neurotransmitter receptors and transporter proteins
  8. 8. NeurobalanceTM  Magnesium (Mg), zinc (Zn) & vitamin B6 are key nutrients required for both neurotransmitter synthesis and function (via receptor and transporter proteins)  Deficiency in one or more of these nutrients can significantly impair normal neurotransmitter production and function  Vitamin B6 is required for transport or accumulation of Mg in cells and tissue  Mg is required for the proper functioning of alkaline phosphatase, the enzyme that facilitates the absorption of vitamin B6  Zinc is needed to convert the inactive form of vitamin B6, pyridoxine, to the active form pyridoxal phosphate
  9. 9. Neurodevelopmental disorders  Evidence suggests a breakdown in several neurotransmitter pathways in neurodevelopmental disorders, particularly dopamine, serotonin and GABA  Mg deficiency common in neurodevelopmental disorders  Mg levels correlate highly with distractibility and excitability  Mg levels associated with hyperactivity and sleep disturbances  Poor conversion of B6 to the active form pyridoxal-5-phosphate  B6 and Mg deficiency may result in accumulation of the tryptophan metabolite kynurenine, which is itself known to be associated with disturbances in neurotransmission (Ames et al., 2002)
  10. 10. Author Intervention Mousain-Bosc et al, 2006 Mousain-Bosc et al, 2004 Duration n= Assessment Findings magnesium8-weeks vitamin B6 (MgB6) regimen (6 mg/kg/d Mg, 0.6 mg/kg/d vit-B6) 40 trial 36 control (age 6-14) DSM-IV Significant reduction in hyperactivity and aggressiveness. Improvements in attention. Mg(2+)/vitamin 12-weeks B6 intake (100 mg/day) 579 boys 231 girls (age 5-12) SNAP-IV and SDQ StarobratMg 6-months Hermelin et al, (200mg/day) or 1997 placebo 50 trial 25 control (age 7-12) DSM-IV Connors Rating Scale Overall improvements in attentional, behavioural and emotional problems. Significant reductions in hyperactivity and improved freedom from distractibility.
  11. 11.  Serum zinc levels have been found to be significantly lower in ADHD children compared to controls  Consumption of certain artificial food colour additives has also been shown to lead to zinc deficiency  Ingestion of 50mg tartrazine by 22 hyperactive males: serum zinc levels decreased urine levels increased behavioural and emotional symptoms deteriorated Ward et al. 1990 The Influence of the Chemical Additive Tartrazine on the Zinc Status of Hyperactive Children—a Double-blind Placebo-controlled Study Journal of Nutritional and Environmental Medicine. 1:51-57
  12. 12. Author Intervention Duration n= Assessment Findings Arnold et al, 2011 13-40mg zinc glycinate 52 (age 6-14) DSM-IV No superiority of zinc when compared with placebo; when zinc was administered twice daily, the optimal weightadjusted dose for amphetamine [could be] decreased by 37% compared with placebo. Huss et al, 2010 4 capsules ‘ESPRICO’ containing Zinc 5mg Phase 1 Zinc or placebo for 8 weeks Phase 2 Zinc or placebo with damphetamine for 2 weeks Phase 3 Zinc or placebo with damphetamine (adjusted) for 3 weeks 12-weeks 579 boys 231 girls (age 5-12) SNAP-IV and SDQ Overall improvements in attentional, behavioural and emotional problems. 6-weeks 26 boys 18 girls (age 5-11) DSM-IV 328 boys 72 girls (age=9.61±1.7) DSM-IV Akhondzadeh methylphenidate et al, 2004 1 mg/kg/day + zinc sulphate ( 55 mg/day) methylphenidate 1 mg/kg/day + placebo (sucrose 55 mg) Bilici et al, 150mg zinc 2004 sulphate 12-weeks Improvements in both groups, but improvements were significantly greater in the zinc group. Overall improvements in hyperactivity, impulsivity and socialization scores but not in attention.
  13. 13. Neurodegenerative disease  Nerve damage can occur as a consequence of dysregulated inflammation or as a result of scarring caused by protein aggregation (such as Lewy bodies, alpha-Synuclein and beta-amyloid)  Zinc has critical functions in the brain. Lack of zinc can cause neuronal death  Patients with Alzheimer's are often found to be zinc deficient when compared with age-matched controls (Brewer et al., 2012)  Mg deficiency has also been shown in patients with mild to moderate AD (Barbaqallo et al., 2011)
  14. 14. Women’s health  Reduced levels of several essential nutrients, including Mg, zinc and vitamin B6, are common in: - women using oral contraceptives - women using hormone replacement therapy (HRT) - postmenopausal women  Given the role of Mg, zinc and vitamin B6 in regulating symptoms associated with premenstrual syndrome (PMT) and menopausal symptoms (including the risk of osteoporosis), restoring optimal levels via supplementation may be advisable
  15. 15. NeurobalanceTM key features and benefits Zinc methionine offers superior bioavailability, antioxidant and immune-enhancing properties compared to other forms of zinc. Magnesium citrate is more soluble and bioavailable than magnesium oxide found in many cheaper supplements . Magnesium is required for the proper functioning of alkaline phosphatase, the enzyme that facilitates the absorption of vitamin B6. Pyridoxal-5-phosphate delivers the ‘body-ready’ form of vitamin B6. Vitamin B6 is required for transport or accumulation of magnesium in cells and tissue. cell replication neurotransmitter synthesis & function immune function essential fatty acid metabolism energy production nerve and muscle function adrenal function hormone function neurotransmitter synthesis & function essential fatty acid metabolism calcium metabolism vitamin B6 absorption protein metabolism essential fatty acid metabolism energy production magnesium absorption
  16. 16. NeurobalanceTM Nutritional information Serving size: 2 tablets Amount per tablet % RDA Zinc methionine 14 mg 140 % Magnesium citrate of which magnesium Vitamin B6 (pyridoxal-5-phosphate) 367mg 60 mg 10 mg 16 % 714% Ingredients Magnesium citrate; bulking agent: calcium carbonate; emulsifier: microcrystalline cellulose; zinc methionine; vitamin B6 (pyridoxal-5-phosphate); thickener: hydroxypropyl methylcellulose; anti-caking agents: stearic acid, silicon dioxide, magnesium stearate.
  17. 17. NeurobalanceTM Directions for use Children aged 4-8 years should take 2 tablets daily. Children aged 9-15 years should take 4 tablets daily. Adults and children aged 16+ should take 6 tablets daily. For optimal results take with food and split into 2 doses per day. Do not exceed the daily dose unless advised by a healthcare practitioner. Warnings and contraindications Pregnant or lactating women should consult their doctor before taking any food supplement. This product should not be used as a substitute for a balanced diet. Keep out of the reach of children and away from sunlight. There are no known drug or nutrient interactions associated with Neurobalance™. Free from:  Dairy  Gluten  Lactose  Soya  Yeast  Artificial colourings & flavourings  Not tested on animals  Non-GMO
  18. 18. NeurobalanceTM NeurobalanceTM is a blend of magnesium, zinc and vitamin B6, formulated to aid in normal neurotransmitter production and function. This scientifically formulated supplement offers synergistic benefits to optimise the functioning of the nervous system. Utilising a slow-release delivery system and the most bioavailable forms of each ingredient, NeurobalanceTM ensures optimal blood plasma nutrient levels are maintained throughout the day. • Igennus is the only independent manufacturer of specialist Fatty Acid in the UK. Based in Cambridge the medical innovation hub for the UK:         - Seven Seas - Minami - Biocare - Eskimo 3 - Equizen Merck Pharma Germany  Highly bioavailable nutrients  Synergistic relationship Atrium Pharmatablets between Mg and B6 Canada  Easy-to-swallow  Pharma optimal Elder Split-dosing for Indiabioavailability  Sustained-release tablets for enhanced absorption & optimal tissue distribution Bringwellbenefits for brain function and mood Pharma Sweden  Offers Vifor balance Pharma Swiss Supports neurotransmitter metabolism Supports neurological function Supports hormone balance Supports immune function Supports DNA and protein synthesis Aids in the production of sleep modulators Supports a healthy mood Anti-anxiety benefits
  19. 19. ninab@igennus.com www.igennus.com drninabailey.co.uk 01223 421434 07527384229
  20. 20. Magnesium absorption  Typical magnesium absorption: 40% of magnesium intake absorbed in the small intestine 5% absorbed in the large intestine 55% leaves the body as waste  Forms of magnesium that dissolve well in liquid are more completely absorbed in the gut than less soluble forms  Mg citrate is considered to be highly bioavailable whereas certain forms of magnesium supplements, such as magnesium oxide, may have an absorbable magnesium potency as low as 4% (Lindberg et al., 1990)
  21. 21. Mg citrate Mg gluconate Mg lactate Decreasing solubility Mg carbonate Mg oxalate Mg hydroxide Mg oxide

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