Busygin cv

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Busygin cv

  1. 1. UNIVERSITY OF CALIFORNIA AT BERKELEY • DEPARTMENT OF CHEMICAL ENGINEERING 201 GILMAN HALL • BERKELEY • CA 94720-1462 PHONE (951)-880-7913 EMAIL ibusygin@berkeley.edu IGOR BUSYGIN CURRICULUM VITAE EDUCATION 06/2007 Åbo Akademi University, Turku, Finland Ph.D. in Chemistry (with Minor Subject in Chemical Engineering) ■ Thesis: «Hydrogenation of Vicinal Diketones over Cinchona Alkaloid Modified Pt Supported Catalysts» ■ Advisors: Professor Reko Leino, Professor Dmitry Yu. Murzin 06/2002 Lomonosov Moscow State University, Moscow, Russia M.Sc. in Chemistry ■ M.Sc. Thesis: «Design and Synthesis of Glycoprotein IIb/IIIa Receptor Antagonists» ■ Advisor: Professor Nikolay S. Zefirov PROFESSIONAL EXPERIENCE 06/2009 – ■ Postdoctoral Fellow, Department of Chemical Engineering, University of California at Berkeley current: With Professor Alex Katz, I am developing a synthesis and characterization of novel catalytic materials from precursor metal cluster carbonyl and their derivatives. The resulting materials are used to create solid catalysts with molecularly defined active site. Tuning properties of the active site is performed by variation of calixarene-based phoshine ligands. Thermogravimetry, FT-IR evolved gas analysis, mass spectrometry, TEM, ICP, chemisorption and physisorption analysis are used for materials characterization. The performance of the catalysts will be tested in the gas phase continuous-flow hydrogenation and hydroformylation of alkenes. Design and building of the reactor flow unit capable of running a number of experiments including in-situ FT-IR study of reactive species adsorbed on the catalyst surface are parts of my duties. 06/2008 – ■ Postdoctoral Fellow, Catalytic Research Center, Institute of Technical and Macromolecular 05/2009: Chemistry, RWTH Aachen, Germany I have been involved in the investigation of the epoxides/carbon dioxide co-polymerization reaction. Chemical fixation of CO2 into polymers is a topic of high importance and interest as it suggest a solution to climate change problem. Our team under supervision of Professor Walter Leitner and Dr. Thomas Müller was selected as a winner for the BMS Champions Cup "Science for a Better Life." Also, I participated in "Pathfinder Project," Molecular Science and Engineering (MSE) program. In collaboration with Center for Electron Microscopy, RWTH Aachen University (Prof. Thomas Weirich) I followed the restructuring processes of heterogeneous polymerization catalysts by in-situ TEM microscopy. Finally, I pioneered the work on immortal ring-opening polymerization of cyclic carbonates catalyzed by colloidal double metal cyanides (DMC) and by DMC supported on nanolamellar inorganic oxides. 07/2007 – ■ Magnus Ehrnrooth Foundation Postdoctoral Fellow, conjointly Laboratory of Industrial Chemistry 05/2008: and Laboratory of Organic Chemistry, Åbo Akademi University, Finland Under advisors Professor Dmitry Yu. Murzin and Professor Reko Leino, the first theoretical model accessing the origin of diastereoselectivity in heterogeneous hydrogenation which allows predicting the stereoselectivity on the quantitative level was developed. The model was successfully applied to hydrogenation of chiral α-hydroxyketones over the Pt catalysts supported on inorganic oxides. Geometry and energy for several adsorption modes of the model hydroxykotone as well as whole reaction paths for hydrogenation were studied on the Pt(111) surface by density functional theory (DFT). Theoretically obtained potential energy profiles for the studied hydrogenation mechanisms were used to explain the experimentally observed selectivities.
  2. 2. PROFESSIONAL EXPERIENCE (CONTD) 02/2003 – ■ Doctoral student and Teaching Assistant, Laboratory of Organic Chemistry, 06/2007: Åbo Akademi University, Finland Under advisors Professor Reko Leino and Professor Dmitry Yu. Murzin (Laboratory of Industrial Chemistry, Åbo Akademi University), I studied the enantioselective hydrogenation of vicinal diketones over cinchona alkaloid modified platinum catalysts. Variations of the reactant and modifier structure, kinetic experiments and modeling, dynamic NMR studies, investigation of the organic molecules adsorption on the surface of metal catalysts by IR spectroscopic techniques, DFT investigation of the ligands have been carried out in order to clarify the important structure-selectivity relationships involved in enantiodifferentiation over modified solid catalysts. 02/1998 – ■ Undergraduate and Graduate Research Assistant, Laboratory of Organic Synthesis, Department of 01/2003: Chemistry, Lomonosov Moscow State University, Russia In the laboratory of Professor Nikolay S. Zefirov, I utilized the 2-amino-thiazole core to constrain two main recognition groups of arginine-glycine-aspartic acid tripeptide. A library of new peptidomimetics using traditional synthetic chemistry approaches and parallel chemistry techniques was synthesized. 06/2001 – ■ Summer Intern, Institute of Organometallic Chemistry and Technology (GNIIHTEOS), Moscow 07/2001: I studied process control and intensification in the middle scale industrial production of Methazidium (1,1'-Methylene-bis(2-isonicotinylhydrazine)). RESEARCH EXPERIENCE Chemical small- and middle-scale high pressure and high/low temperature catalytic units; flow reactors; catalysts Engineering: synthesis, characterization and evaluation; kinetic data analysis and modeling; process development Organic Full repertoire of synthetic organic skills with expertise in single crystal growing; handling air-, and Chemistry: moisture sensitive compounds using glovebox and Schlenk techniques; transition metal complexes and cluster chemistry; application of chiral technologies Polymer ring-opening polymerization; copolymerization; coordination polymerization; Chemistry: heterogeneous/homogeneous polymerization catalysis Analytical NMR spectroscopy including 2D & non-standard experiments; FT-IR spectroscopy of solids (analysis of Techniques: adsorbed species), liquids and gases (including trace impurities with detection limit of 200 ppm); methods of thermal analysis including in-line TGA/MS/IR; TEM; surface area; GC, HPLC, MS and GPC analysis Other: Swagelok tubing and fitting TEACHING EXPERIENCE Research Mentor undergraduate researchers at ÅA (2005–2007), MSU (2001–2002) and UCB (2010) Teaching Assistant organic chemistry IIB, ÅA 2007 Reviewer Journal of Organic Chemistry, 2009 – PERSONAL SCIENTIFIC GRANTS AND AWARDS 2009 Selected as Top 5 candidates for the European Federation of Catalysis Societies (EFCATS) thesis award. 2008 International Association of Catalysis Societies (IACS) Young Scientist Award 2007 Magnus Ehrnrooth Postdoctoral Research Fellowship 2007 Rector of Åbo Akademi University Predoctoral Research Fellowship 2006 PhD Scholarship of the Ministry of Education, Finnish National Graduate School of Organic Chemistry and Chemical Biology PROFESSIONAL AFFILIATIONS American Chemical Society (ACS): Division of Industrial & Engineering Chemistry, Division of Organic Chemistry, Division of Inorganic Chemistry, Division of Polymer Chemistry April 28, 2010 Busygin CV Page 2 of 6
  3. 3. LANGUAGE SKILLS Russian (mother tongue), English (fluent), Swedish (basics) COMPUTER SKILLS Operating systems: Windows, Linux Kinetic modeling: ModEst, gProms, DynaFit, Matlab Quantum chemical calculations: Accelrys Materials Studio, Turbomole, Spartan Applications: Bruker XWinNMR/XWinPlot, Topspin NMR, Perch Software, LabVIEW, WinGPC, OMNIC software, Ortep Office: MS Office, OpenOffice, ChemOffice, Origin, ACD Labs Languages: BASH Programming, HTML, Pascal PARTICIPATION AT TRAINING SCHOOLS ■ IDECAT Advanced Course on Catalysis “From Molecular to Reactor Design”, Villars-sur-Ollon, Switzerland, February 1-6, 2009 ■ “Advanced polymer analysis” organized by PSS, Aachen, Germany, November 4, 2008 ■ 15th Jyväskylä Summer School, Jyväskylä, Finland, August 15-26, 2005 ■ “Materials Studio workshop” organized by CSC (Finnish IT center for science), Espoo, Finland, June 14- 15, 2005 ■ International academic summer school “Advanced Experimental Methods in Chemical Engineering”, Kuressaare, Estonia, August 5-9, 2004 ■ “MDL Crossfire-course” organized by CSC (Finnish IT center for science), Turku, Finland, April 29, 2003 ■ Symposium in Supported Catalysts, Åbo Akademi University, Turku, Finland, February 21, 2003 PERSONS WHO CAN BE CONTACTED FOR THE REFERENCE ■ Prof. Dmitry Yu. Murzin Laboratory of Industrial Chemistry, Åbo Akademi University, Biskopsgatan 8, 20500 Turku, Finland. Tel.: +358-(2)-215-4985; Fax: +358-(2)-215-4479 dmurzin@abo.fi ■ Prof. Reko Leino Laboratory of Organic Chemistry, Åbo Akademi University, Biskopsgatan 8, 20500 Turku, Finland. Tel.: +358-(2)-215-4132; Fax: +358-(2)-215-4866 rleino@abo.fi ■ Prof. Walter Leitner Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 1, 52074 Aachen Germany. Tel: +49-(241)-802-6480 Fax: +49-(241)-802-2177 leitner@itmc.rwth-aachen.de ■ Prof. Leonid M. Kustov Head of the Laboratory of Development and Study of Polyfunctional Catalysts, N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia. Tel./Fax: +7-(499)-137-2935 lmk@ioc.ac.ru April 28, 2010 Busygin CV Page 3 of 6
  4. 4. LIST OF PUBLICATIONS (ORIGINAL PAPERS) 1. Igor Busygin, Antti Taskinen, Ville Nieminen, Esa Toukoniitty, Thomas Stillger, Reko Leino, Dmitry Yu. Murzin: Experimental and Theoretical Analysis of Asymmetric Induction in Heterogeneous Catalysis: Diastereoselective Hydrogenation of Chiral α-Hydroxyketones over Pt Catalyst, J. Am. Chem. Soc. 2009, 131, 4449–4462. 2. Igor Busygin, Antti Taskinen, Ville Nieminen, Jari Sinkkonen, Esa Toukoniitty, Reijo Sillanpää, Dmitry Yu. Murzin, Reko Leino: A Combined NMR, DFT and X-ray Investigation of Some Cinchona Alkaloid O-Ethers, J. Org. Chem. 2008, 73, 6559–6569. 3. Igor Busygin, Johan Wärnå, Esa Toukoniitty, Dmitry Yu. Murzin, Reko Leino: Hydrogenation of 1-Phenyl-1,2-propanedione over Pt Catalysts Modified by Cinchona Alkaloid O-Ethers and the Kinetic Resolution of the 1-Hydroxyketones Generated, J. Catal. 2008, 254, 339–348. 4. Igor Busygin, Olga P. Tkachenko, Ville Nieminen, Victor Yu. Borovkov, Reijo Sillanpää, Esa Toukoniitty, Dmitry Yu. Murzin, Leonid M. Kustov, Reko Leino: Interaction of Cinchonidine and 1- Phenyl-1,2-Propanedione on the Surface of a Chirally Modified Pt/Al2O3 Hydrogenation Catalyst, J. Phys. Chem. C 2007, 111, 9374–9383. 5. Igor Busygin, Michael Rosenholm, Esa Toukoniitty, Dmitry Yu. Murzin, Reko Leino: Hydrogenation of 1,2-Indanedione over Heterogeneous Cinchonidine-Modified Platinum Catalysts, Catal. Lett. 2007, 117, 91–98. 6. Igor Busygin, Esa Toukoniitty, Reko Leino, Dmitry Yu. Murzin: Effect of Modifier Structure in Asymmetric 1-Phenylpropane-1,2-dione Hydrogenation, J. Mol. Catal. A: Chem. 2005, 236, 227–235. 7. Igor Busygin, Esa Toukoniitty, Reijo Sillanpää, Dmitry Yu. Murzin, Reko Leino: Synthesis of Chiral Catalyst Modifiers by Hydrosilylation of Cinchonidine and Their Application in the Hydrogenation of 1-Phenylpropane-1,2-dione and Ethyl Pyruvate over a Supported Pt/Al2O3 Catalyst, Eur. J. Org. Chem. 2005, 2811–2821. 8. Esa Toukoniitty, Igor Busygin, Reko Leino, Dmitry Yu. Murzin: Asymmetric Hydrogenation of 1- Phenylpropane-1,2-dione Over Cinchona-Modified Pt: Role of the C-9 OH Group of Cinchonidine, J. Catal. 2004, 227, 210–216. 9. Malena E. Sandberg, Denise Schellmann, Gerda Brunhofer, Thomas Erker, Igor Busygin, Reko Leino, Pia M. Vuorela, Adyary Fallarero: Pros and Cons of Using Resazurin Staining for Quantification of Viable Staphylococcus Aureus Biofilms in a Screening Assay J. Microbiol. Methods 2009, 78, 104–106. 10. Igor Busygin, Reko Leino, Dmitry Yu. Murzin: Relative Adsorption Strength of the Modifier and Substrate in the Orito Reaction manuscript in preparation LIST OF PUBLICATIONS (PATENTS) 1. Anthony Kermagoret, Yvonne Dienes, Igor Busygin, Burkhard Köhler, Walter Leitner: Aliphatische Polycarbonate durch immortale Polymerisation von cyclischen Carbonaten (Aliphatic Polycarbonates by Immortal Polymerization of Cyclic Carbonates) patent pending (to Bayer Material Science) PRESENTATIONS (INVITED SPEAKER) 1. I. Busygin: Hydrogenation of Ketones over Chirally Modified Metal Catalysts, BMS Catalysis Center Aachen, March 4, 2008 2. I. Busygin: Understanding Chiral Induction in Cinchona Alkaloid Modified Metal Catalysis, Centre for the Theory and Application of Catalysis (CenTACat), School of Chemistry and Chemical Engineering, Queen's University Belfast, October 31, 2008 April 28, 2010 Busygin CV Page 4 of 6
  5. 5. LIST OF PUBLICATIONS (CONFERENCE PRESENTATIONS) 1. W. Offermans, I. Busygin, G. Erre, C. Gürtler, A. Kermagoret, W. Leitner, A. Subhani, T. E. Müller: Quantum Chemical Investigations into the Catalytic Copolymerisation of CO2 and Epoxides. EUROPACAT IX, Salamanca, Spain, August 30-September 4, 2009 (poster). 2. W. Offermans, I. Busygin, G. Erre, C. Gürtler, A. Kermagoret, A. Subhani, W. Leitner, T. E. Müller: Kinetic and Mechanistic Model for the Copolymerization of Epoxides and Carbon Dioxide. 42 Jahrestreffen Deutscher Katalytiker, Weimar, Germany, March 11-13, 2009 (poster). 3. I. Busygin, G. Erre, C. Gürtler, A. Kermagoret, W. Leitner, W. Offermans, A. Subhani, T. E. Müller: Investigations into the Polymerization of CO2 and Epoxides. Coordination Chemistry Congress of the French Chemistry Society, Reims, France, January 22-23, 2009 (poster). 4. I. Busygin, A. Taskinen, V. Nieminen, R. Leino, D. Yu. Murzin: Chiral Induction in the Hydrogenation of α-Hydroxyketones over Pt Catalyst. 14th International Congress on Catalysis, 14th ICC, Seoul, Korea, July 13-18, 2008 (poster). 5. I. Busygin, A. Taskinen, V. Nieminen, R. Leino, D. Yu. Murzin: Chiral Induction in the Hydrogenation of α-Hydroxyketones over Pt Catalyst. 12th International Conference on Theoretical Aspects of Catalysis, ICTAC-12, Varna, Bulgaria, June 25- 29, 2008 (oral presentation). 6. I. Busygin, E. Toukoniitty, V. Nieminen, A. Taskinen, D. Yu. Murzin, R. Leino: Hydrogenation of Vicinal Diketones over Cinchona Alkaloid Modified Platinum. Abstracts of Papers, 235th ACS National Meeting, New Orleans, LA, United States, April 6-10, 2008 (oral presentation). 7. I. Busygin, J. Sinkkonen, V. Nieminen and R. Leino: Dynamic NMR Investigation of Cinchona Alkaloid O-Ethers, The XXIX Finnish NMR Symposium, Herrankukkaro, Rymättylä, June 13-15, 2007 (oral presentation). 8. I. Busygin, D. Yu. Murzin and R. Leino: Hydrogenation of Vicinal Diketones over Cinchona Alkaloid Modified Platinum: An Update, INNOVATION I, COST-D40 Action in Innovative Catalysis: New Processes and Selectivities, Dublin, May 21-22, 2007 (oral presentation). 9. I. Busygin, E. Toukoniitty, J. Wärnå, D. Yu. Murzin and R. Leino: Hydrogenation of 1-Phenyl-1,2- Propanedione over Pt/Al2O3 Modified by Cinchona Alkaloid C9-O-Ethers, Book of Abstract, p. 258, APCAT 4, Singapore, December 6-8, 2006 (poster). 10. I. Busygin, M. Rosenholm, E. Toukoniitty, D. Yu. Murzin and R. Leino: A Study of Heterogeneous Hydrogenation of 1,2-Indanedione over Cinchonidine-Modified Platinum Catalysts, J. Mex. Chem. Soc. 2006, Special Issue 1, 50, p.228, IUPAC ICOS-16, 16th International Conference on Organic Synthesis, Mérida, Yucatán, México (poster). 11. I. Busygin, E. Toukoniitty, D. Yu. Murzin, and R. Leino: Synthesis of Chiral Catalyst Modifiers by Hydrosilylation of Cinchonidine and their Application in the Hydrogenation of 1-Phenylpropane-1,2- dione and Ethyl Pyruvate over a Supported Pt/Al2O3 Catalyst, Book of Abstracts, p.34, VIII Spring Meeting of Synthetic Chemistry, Turku, Finland, March 17-18, 2005 (poster). 12. I. Busygin, E. Toukoniitty, R. Sjöholm, R. Leino and D. Yu. Murzin: Asymmetric Hydrogenation of 1-Phenylpropane-1,2-dione: Structure-Selectivity Relationships Involved in the Enantiodifferentiation over Chirally Modified Solid Catalyst, Book of Abstracts, p.55, International Conference Highly-Organized Catalytic Systems, HOCS-2004, Moscow, Russia, June 14-17, 2004 (poster). 13. I. Busygin, E. Toukoniitty, R. Sjöholm, D. Yu. Murzin and R. Leino: Asymmetric Hydrogenation of 1- Phenylpropane-1,2-dione: From Reaction Kinetics to Mechanism, Book of Abstracts, p. 22, VII Synthetic Chemistry Meeting and XXVI Finnish NMR Symposium, Keuruu, Finland, June 8-11, 2004 (poster). 14. I. Busygin, E. Toukoniitty, D. Yu. Murzin, R. Sjöholm and R. Leino: New Chiral Catalyst Modifiers by Hydrosilylation of Cinchonidine, Book of Abstracts, p. 95, 13th European Symposium on Organic Chemistry, Cavtat-Dubrovnik, Croatia, September 10-15, 2003 (oral presentation). April 28, 2010 Busygin CV Page 5 of 6
  6. 6. LIST OF PUBLICATIONS (CONFERENCE PRESENTATIONS, CONTD) 15. E. Toukoniitty, I. Busygin, A. Taskinen, V. Nieminen, B. Toukoniitty, J. Wärnå, R. Leino, J.-P. Mikkola, D. Yu. Murzin, T. Salmi: Towards Understanding of Three-Phase Catalysis for Fine Chemicals Production: Interdisciplinary Combination of Theory, Practice and Chemical Engineering, 18th International Congress of Chemical and Process Engineering, CHISA-2008, Praha, Czech Republic, 24- 28 August, 2008 (oral presentation). 16. E. Toukoniitty, V. Nieminen, I. Busygin, A. Taskinen, M. Hotokka, R. Leino and D. Yu. Murzin: Systematic Kinetic And Theoretical Study Of Enantioselective 1-Phenylpropane-1,2-Dione Hydrogenation, Book of Abstracts, The 19th North American Meeting, Philadelphia, Pennsylvania, May 22–27, 2005 (oral presentation). 17. E. Toukoniitty, I. Busygin, S. Franceschini, R. Leino, A. Vaccari, D. Yu. Murzin: New Catalyst Modifiers for 1-Phenylpropane-1,2-dione, Ethyl Pyruvate and Tiglic Acid Hydrogenation over Pt/Al2O3 and Pd/Al2O3 Catalysts, Book of Abstracts, 7th International Symposium on Catalysis Applied to Fine Chemicals, Bingen/Mainz, Germany, October 23–27, 2005 (poster). 18. V. Nieminen, A. Taskinen, J. Sinkkonen, I. Busygin, E. Toukoniitty and D. Yu. Murzin: The Role Of Modifier Structure And Conformation In Heterogeneous Enantioselective Hydrogenation, EUROPACAT VIII, Turku, Finland, August 26-31, 2007 (oral presentation). 19. J. Sinkkonen, V. Nieminen, I. Busygin, E. Toukoniitty: Conformational Analysis of Cinchonine, Cinchonidine and Their Methoxy Derivatives by NMR and Computational Methods. Book of Abstracts p.268, EUROMAR 2005 /EENC 2005, Veldhoven, The Netherlands, July 3-8, 2005 (poster). 20. V. Nieminen, A. Taskinen, J. Sinkkonen, I. Busygin, E. Toukoniitty, D. Yu. Murzin: Revealing Enantioselectivity in Hydrogenation of Ketones on Heterogeneous Catalysts, VIII International Symposium on Catalysis Applied to Fine Chemicals, CAFC-8, Verbania-Pallanza, Italy, September 16-20, 2007 (oral presentation). April 28, 2010 Busygin CV Page 6 of 6

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