Sharing and Open Knowledge and the Future of Scientific Research Hiroaki Kitano The Systems Biology Institute Sony Compute...
 
EGF Receptor Cascade Oda, et al. Molecular Systems Biology, 2005
Architectural Feature Kitano, Nature Reviews Genetics, Nov. 2004
Copyright ©2007 by the National Academy of Sciences Kim, Pan-Jun et al. (2007) Proc. Natl. Acad. Sci. USA 104, 13638-13642...
Ma et al, Molecular Systems Biology, Sept 2007
Bow-Tie Architecture of Wikipedia links Capocci, et al., Phys Rev. E 74, 036116, 2006
EGF Receptor Cascade Oda, et al. Molecular Systems Biology, 2005
Oda, et al. Molecular Systems Biology, 2005
 
TLR Bow-Tie Structure Oda and Kitano, Molecular Systems Biology, April 2006
低下する製薬産業の生産性
Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100,  7977-...
Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100,  7977-...
Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100,  7977-...
 
朝鮮人参の成分分析 Wang, M. et al., Phytother Res. 2005 Mar;19(3):173-82
Open Pharma <ul><li>Combination of Generic compounds to generate highly effective drugs </li></ul><ul><li>Equivalent effic...
“ PAYAO” Web 2.0 Community Tagging System to SBML models Okinawa Institute of Science and Technology The Systems Biology I...
“PAYAO” <ul><li>an artificial floating raft where fish congregate  </li></ul>
Payao: Web2.0 Community-Based Biological Knowledge Accumulation System
SBML Models Tagging System Manage  Models,  Users, Groups Register a model Store  models,  Tags,  Comments Login Users Vis...
Model View
Model View with Tag Marks
Tag
View a Tag
Add Comments to a Tag
View Comments to a Tag
PubMed ID Link
Healthcare & Wellness Concierge Genome Diagnosis (23 and me) Wellness (India, etc) Personalized & Preventive medicine How ...
Summary <ul><li>Networks are complex but has sort of “design principles” </li></ul><ul><li>Long tail drug need to be pursu...
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Sharing and Open Knowledge and the Future of Scientific Research by Hiroaki Kitano

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Sharing and Open Knowledge and the Future of Scientific Research by Hiroaki Kitano

  1. 1. Sharing and Open Knowledge and the Future of Scientific Research Hiroaki Kitano The Systems Biology Institute Sony Computer Science Laboratories, Inc.
  2. 3. EGF Receptor Cascade Oda, et al. Molecular Systems Biology, 2005
  3. 4. Architectural Feature Kitano, Nature Reviews Genetics, Nov. 2004
  4. 5. Copyright ©2007 by the National Academy of Sciences Kim, Pan-Jun et al. (2007) Proc. Natl. Acad. Sci. USA 104, 13638-13642 Fig. 1. Characteristics of essential and nonessential metabolites in E. coli metabolism
  5. 6. Ma et al, Molecular Systems Biology, Sept 2007
  6. 7. Bow-Tie Architecture of Wikipedia links Capocci, et al., Phys Rev. E 74, 036116, 2006
  7. 8. EGF Receptor Cascade Oda, et al. Molecular Systems Biology, 2005
  8. 9. Oda, et al. Molecular Systems Biology, 2005
  9. 11. TLR Bow-Tie Structure Oda and Kitano, Molecular Systems Biology, April 2006
  10. 12. 低下する製薬産業の生産性
  11. 13. Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7977-7982 Multicomponent therapeutics that prevent proliferation of fluconazole-resistant C. albicans CombinatoRX (CRXX: NASDAQ) cHTS
  12. 14. Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7977-7982 Chlorpromazine , an antipsychotic agent, and pentamidine , an antiprotozoal agent, together selectively prevent tumor cell growth in vitro and in vivo Phase 1/2A Stage
  13. 15. Copyright ©2003 by the National Academy of Sciences Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7977-7982 Chlorpromazine , an antipsychotic agent, and pentamidine , an antiprotozoal agent, together selectively prevent tumor cell growth in vitro and in vivo Phase 1/2A Stage Efficacy
  14. 17. 朝鮮人参の成分分析 Wang, M. et al., Phytother Res. 2005 Mar;19(3):173-82
  15. 18. Open Pharma <ul><li>Combination of Generic compounds to generate highly effective drugs </li></ul><ul><li>Equivalent efficacy by partial replacement of compounds </li></ul><ul><li>Value lies in “Combination” rather than compound itself. </li></ul><ul><li>Toward open source pharmaceutical industry </li></ul>The Rule of the Game Will Change
  16. 19. “ PAYAO” Web 2.0 Community Tagging System to SBML models Okinawa Institute of Science and Technology The Systems Biology Institute
  17. 20. “PAYAO” <ul><li>an artificial floating raft where fish congregate </li></ul>
  18. 21. Payao: Web2.0 Community-Based Biological Knowledge Accumulation System
  19. 22. SBML Models Tagging System Manage Models, Users, Groups Register a model Store models, Tags, Comments Login Users Visitors Model Owner Add Comments Add/Edit Tags to the model View Models with CellDesigner notation Group A Group B *CellDesigner files PAYAO SBML Models Tagging System SBML files
  20. 23. Model View
  21. 24. Model View with Tag Marks
  22. 25. Tag
  23. 26. View a Tag
  24. 27. Add Comments to a Tag
  25. 28. View Comments to a Tag
  26. 29. PubMed ID Link
  27. 30. Healthcare & Wellness Concierge Genome Diagnosis (23 and me) Wellness (India, etc) Personalized & Preventive medicine How to integrate medicine and wellness? Herbal medicine, meditation, etc. Novel Drug Design and Integrated Healthcare Support
  28. 31. Summary <ul><li>Networks are complex but has sort of “design principles” </li></ul><ul><li>Long tail drug need to be pursued to create more effective drugs </li></ul><ul><li>Open Pharma may open up a whole new paradigm of drug design, distribution, and services. </li></ul><ul><li>Open infrastructure is the key for success </li></ul>

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