Hemolytic crisis• Acute acclerated drop in hemoglobin level.• Occur in patients with co-existent G6PDdeficiency.
Chest• Lung:• Consolidation due to chestinfection.• Heart:• Cardiomegaly and heart failure dueto increased cardiac out put.• Mediastinum:• Posterior mediastinal mass lesiondue to extramedullary hemopoiesis.
Skeletal manifestations of sickle cellanemia• Bone marrow hyperplasia.• Bone infarction.• Bone infection.• Growth disturbances.
Bone marrow hyperplasia• Less sever than thalassemia.
Long bones• Diffuse osteoporosis,• Medullary expansion,• Cortical thinning,• Coarse trabeculations (honey comb)• (reactive sclerosis of the secondary trabeculae afterdestruction of the primary trabeculae),• Endosteal apposition, (another response todestruction of the medullary trabeculae by inwardcortical thickening, then cortical splitting giving bonewithin bone appearance). &• Wide vascular channels.
• MRI:• Diffuse low signal on T1 & T2 WIs• (due to persistent red marrow).• Bone scan:• Diffuse symmetrical increased uptake.