Nutraceuticals2 130304233911-phpapp02

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Future of Medicine

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Nutraceuticals2 130304233911-phpapp02

  1. 1. BySwetha .k(170212887009)Under the guidance ofDr. SnehaGRCP( DEPT OF PHARMACOLOGY) 1
  2. 2. DEFINITIONThe term nutraceutical was coined by StephenDefelice .“A NEUTRACEUTICAL is any substance thatis a food or a part of food and provides medical orhealth benefits, including the prevention andtreatment of disease”.GRCP( DEPT OF PHARMACOLOGY) 2
  3. 3. CLASSIFICATIONNeutraceuticals can be classified based on: Natural source Pharmacological conditions Chemical constitutionGRCP( DEPT OF PHARMACOLOGY) 3
  4. 4. CLASSIFICATION BASED ON CHEMICAL GROUPSs.no Class Examples1 Inorganic mineralsupplementsMinerals2 Probiotics Helpful bacteria3 Prebiotics Digestive enzymes4 Dietary fibres Fibres5 Antioxidants Natural antioxidants6 PhytochemicalsFatty acids Omega 3 fatty acidsPhenolics Tea polyphenolsIsoprenoids carotenoidsLipids SphingolipidsProteins soyaproteins7 Herbs as functional food --------
  5. 5. INORGANIC MINERAL SUPPLEMENTCalciumMagnesiumManganeseBoronCopperZincPhosphorusGRCP( DEPT OF PHARMACOLOGY) 5
  6. 6. PROBIOTICSLive microorganisms which, whenadministered in adequate amounts, confer a healthbenefit on the host Species of Lactobacillus Bifidobacterium yeast Saccharomyces cerevisiae some E. coli and Bacillus species are also used asprobioticsGRCP( DEPT OF PHARMACOLOGY) 6
  7. 7. PREBIOTICSNondigestible substances that provide a beneficialphysiological effect for the host by selectivelystimulating the favorable growth of a limitednumber of indigenous bacteria.Commonly known prebiotics are: Oligofructose Inulin Galacto-oligosaccharides LactuloseGRCP( DEPT OF PHARMACOLOGY) 7
  8. 8. DIETARY FIBRESDietary fibers are of two types: Water insoluble fibers Water soluble fibersDaily recommended intake is 30-40 gms.SOURCES:Whole grain cereals, wheat products.Oats , dried beans, legumes.GRCP( DEPT OF PHARMACOLOGY) 8
  9. 9. ANTIOXIDANTSAntioxidants are of 3 categories:True antioxidantsReducing agentsAntioxidant synergistsDeficiency causes diseases like cancers,rheumatoid arthritis, alzheimers disease,cardiovascular diseases.GRCP( DEPT OF PHARMACOLOGY) 9
  10. 10. ANTIOXIDANT SOURCEVITAMINSvitamin C Citrus fruits, vegetablesvitamin E Grains ,nuts, oilsCAROTENOIDSLycopene TomatoesBeta carotene Carrots, sweet potatoXANTHOPHYLLSBeta cryptoxanthin Mango ,papaya,orangesFLAVANOIDSRutin Tobacco, eucalyptus speciesLuteolin Lemon, red pepper, oliveQuercitin Onion, apple skin ,black grapesKaempferol Grape fruit , teaLiquiritin liquoriceGRCP( DEPT OF PHARMACOLOGY) 10
  11. 11. HERBS AS FUNCTIONAL FOODSFLAX SEEDSSOURCE : Linum usitatissimum.FAMILY : Linaceae.CHEMICAL CONSTITUENTS :Gamma linolenic acidAlpha linolenic acidSecoisolariciresinol(SDG)Lignans, proteins.GRCP( DEPT OF PHARMACOLOGY) 11
  12. 12. FLAX SEEDSUSES : Prevents mammary, colon andrectal cancers. Reduces BP in hypertensive patients. Reduces diabetes and coronaryheart diseases.GRCP( DEPT OF PHARMACOLOGY) 12
  13. 13. GINKGO BILOBAFAMILY : GinkgoaceaeCHEMICAL CONSTITUENTS :Bilobelin, ginkgetin,isoginkgetin, flavanols,ginkgolides A,B,C.USES : In treating asthma,impairment of memory. Leaves are able to alleviate the adverse effectsof PAF.GRCP( DEPT OF PHARMACOLOGY) 13
  14. 14. MECHANISM OF ACTION14
  15. 15. SPIRULINASOURCE :Spindina platensis or s.maximaFAMILY :OscillatoriaceaeCHEMICAL CONSTITUENTSGamma linoleic acid,Oleic acid ,Glycolipids and sulpholipids.Rich in vitamin B andbetacarotenes.Phycocyanin.GRCP( DEPT OF PHARMACOLOGY) 15
  16. 16. SPIRULINAUSES :Immunostimulant activity.Management of HIV and other viralinfections such as herpes,cytomegalovirus, influenza, mumpsTo treat arthritis, atherosclerosis, diabetes andaging processGRCP( DEPT OF PHARMACOLOGY) 16
  17. 17. KARELASOURCE :Momordica charantiaFAMILY :CucurbitaceaeUSES : Hypoglycemic effect Extract of karela increasesrate of glycogen synthesisby 4-5 fold in liver.GRCP( DEPT OF PHARMACOLOGY) 17
  18. 18. TURMERIC CURCUMINOIDSSOURCE : Rhizomes of Curcuma longaFAMILY : ZingiberaceaeCHEMICAL CONSTITUENTS :Curcumin, desmethoxy curcumin,bisdesmethoxy curcuminUSES : Antimicrobial activity Recent findings indicatethat it has integraseenzyme inhibitor activityGRCP( DEPT OF PHARMACOLOGY) 18
  19. 19. SOYA PRODUCTSSOURCE : Glycine maxFAMILY: LeguminoseaeCHEMICAL CONSTITUENTS:Daidzein, genisteinUSES : Prevents estrogen–dependant cancers Geinstein inhibits protein tyrosine kinaseand DNA topoisomerase-IIGRCP( DEPT OF PHARMACOLOGY) 19
  20. 20. GARLICSOURCE :Bulbs of Allium sativumFAMILY: LiliaceaeCHEMICAL CONSTITUENTS :Allicin , allin , ajoeneUSES : In treatment of hyperlipidaemia. It shows antihypertensive, hypoglycemic,anti spasmodic activity. Prevents colon and lung cancers.GRCP( DEPT OF PHARMACOLOGY) 20
  21. 21. TOMATO LYCOPENESSOURCE : Lycopersicon esculentumFAMILY: SolanaceaeCHEMICAL CONSTITUENTS : LycopeneUSES : Prevents prostate cancer Reduces risk of cancers of digestive tract,pancreas, cervix, bladder and skin.GRCP( DEPT OF PHARMACOLOGY) 21
  22. 22. FENUGREEKSOURCE :Trigonella foenum-graecumFAMILY: LeguminoseaeCHEMICAL CONSTITUENTS : Alkaloids(gentianine and trigonelline)flavanoids,coumarins,proteins,amino acids,steroid saponins.GRCP( DEPT OF PHARMACOLOGY) 22
  23. 23. FENUGREEKUSES : In treatment of anorexia,gastritis.Fenugreek possesslaxative, expectorant, demulcentproperties. Shows hypoglycemic andhypocholesterolemic propertiesGRCP( DEPT OF PHARMACOLOGY) 23
  24. 24. GINSENGSOURCE : Panax ginsengFAMILY: AraliaceaeCHEMICAL CONSTITUENTS:ProtopanaxadiolPolysaccharidesStarch, sterolsPolyacetylenes, choline,Vitamins B1,B2,B12,Pantothenic acid, biotin.GRCP( DEPT OF PHARMACOLOGY) 24
  25. 25. GINSENGUSES :Ginseng helps the body to copewith stress and fatigueIn treatment of hypertensionand hypoglycemiaModifies liver function andmetabolism.GRCP( DEPT OF PHARMACOLOGY) 25
  26. 26. EXAMPLES OF NUTRACEUTICALSCURRENTLY AVAILABLE IN MARKETVITAMIN AND MINERAL SUPPLEMENTS :VitaminA (Beta- Carotene)ADDITIONAL SUPPLEMENTS :cod liver oil, primrose oil,glucosamine, garlic etc.SPORTS PRODUCTS-Glucon-D (Heinz),Glucose D (Dabur)GRCP( DEPT OF PHARMACOLOGY) 26
  27. 27. MARKETED PREPARATIONSGRCP( DEPT OF PHARMACOLOGY) 27
  28. 28. REFERENCES Text book of pharmacognosy and phytochemistry by Biren shah andA.K.Seth, pg.no-471-479. Probiotics: Applications in Gastrointestinal Health & Disease Presentedin conjunction with the American College of Gastroenterology’s 72ndAnnual Scientific Meeting, Autumn 2007) http://www.fao.org/ag/agn/agns/micro_probiotics_en.asp De Felice L Stephen. The nutraceutical revolution, itsimpact on food industry. Trends in Food Sci. and Tech1995; 6:59-61. Jack DB. Keep taking the tomatoes - the exciting world ofnutraceuticals. Mol Med Today 1995; 1(3):118-21. Brower B. Nutraceuticals: poised for a healthy slice of themarket. Nat Biotechnology 1998; 16: 728-33.Mannion M. Nutraceutical revolution continues atfoundation for innovation in medicine conference. Am JNat Med 1998; 5:30-3.GRCP( DEPT OF PHARMACOLOGY) 28
  29. 29. GRCP( DEPT OF PHARMACOLOGY) 29

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