Adopting Tibco Spotfire in Bio-Informatics


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  • Adopting Tibco Spotfire in Bio-Informatics

    1. 1. Adopting Tibco Spotfire in Bio-Informatics Herwig Van Marck
    2. 2. Tibotec – Virco Who we are and what we do <ul><ul><li>Virco applies advanced technologies to improve the diagnosis and management of infectious diseases </li></ul></ul><ul><ul><ul><li>Virco TYPE HIV-1 </li></ul></ul></ul><ul><ul><ul><li>VircoNet </li></ul></ul></ul><ul><ul><ul><li>Antivirogram </li></ul></ul></ul>Footer <ul><ul><li>Tibotec aims to discover innovative and effective drug candidates against a range of life-threatening infectious diseases </li></ul></ul><ul><ul><ul><li>HIV </li></ul></ul></ul><ul><ul><ul><li>Tuberculosis </li></ul></ul></ul><ul><ul><ul><li>HCV </li></ul></ul></ul>
    3. 3. People & locations Footer <ul><li>Employees </li></ul><ul><li>Tibotec & Virco 550 </li></ul><ul><ul><li>Drug Discovery </li></ul></ul><ul><ul><li>Drug Development </li></ul></ul><ul><ul><li>Virco </li></ul></ul><ul><ul><li>Shared Services </li></ul></ul><ul><li>Facilities </li></ul><ul><li>Tibotec, Virco </li></ul><ul><ul><li>Mechelen, Belgium </li></ul></ul><ul><li>VircoLab, Inc </li></ul><ul><ul><li>Raritan, NJ; Durham, NC </li></ul></ul><ul><li>Tibotec, Inc. </li></ul><ul><li>Yardley, PA </li></ul><ul><li>Tibotec Pharmaceuticals Ltd </li></ul><ul><ul><li>Cork, Ireland </li></ul></ul>
    4. 4. Correlation Analysis (dummy data) Footer
    5. 5. Overview <ul><ul><li>Advantages TIBCO Spotfire over DecisionSite </li></ul></ul><ul><ul><ul><li>Improved formatting </li></ul></ul></ul><ul><ul><ul><ul><li>Better use of display real estate </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Output closer to a report </li></ul></ul></ul></ul><ul><ul><ul><li>Custom expressions </li></ul></ul></ul><ul><ul><ul><li>Details visualisations </li></ul></ul></ul><ul><ul><ul><li>Multiple data tables </li></ul></ul></ul><ul><ul><ul><li>Column from marked </li></ul></ul></ul><ul><ul><ul><li>Text area for annotations and shortcuts </li></ul></ul></ul><ul><ul><ul><li>Tags </li></ul></ul></ul><ul><ul><li>Disadvantages </li></ul></ul><ul><ul><ul><li>No support for chemical structures yet </li></ul></ul></ul>Footer
    6. 6. Custom Expressions <ul><ul><li>Avoid columns that are only used in a particular visualisation to clutter the data </li></ul></ul><ul><ul><li>Different labels for different visualisations </li></ul></ul><ul><ul><ul><ul><li>Count() as [# viruses per bin] </li></ul></ul></ul></ul><ul><ul><li>Aggregation </li></ul></ul><ul><ul><ul><ul><li>Covariance([pFC],[pFC (2)]) / (StdDev([pFC]) * StdDev([pFC (2)])) as [Correlation] </li></ul></ul></ul></ul>Footer
    7. 7. Details visualisations <ul><ul><li>Data selection depends on marked data in other visualisation </li></ul></ul><ul><ul><ul><li>Use trellis to provide title </li></ul></ul></ul>Footer
    8. 8. Using Multiple Data Tables <ul><ul><li>Different data sources </li></ul></ul><ul><ul><ul><li>One-to-many relations between different data tables </li></ul></ul></ul><ul><ul><li>Same data in different pivot state </li></ul></ul><ul><ul><li>Refreshing data or using files as templates </li></ul></ul><ul><ul><li>Cartesian product </li></ul></ul>Footer
    9. 9. Using Multiple Data Tables: Cartesian product <ul><ul><li>Duplicate the source data by adding a data table using the “Existing data table …” option </li></ul></ul>Footer
    10. 10. Multiple Data Tables: Cartesian product <ul><ul><li>Create the Cartesian product by inserting columns with the “Existing data table …” option </li></ul></ul>Footer
    11. 11. Using Multiple Data Tables: saving <ul><ul><li>Use “Linked …” when saving so data from existing data tables stays linked </li></ul></ul><ul><ul><li>“ Setting for Linked Data” allows you to specify which tables to fix </li></ul></ul><ul><ul><li>Non linked data sources can always be replaced with new data </li></ul></ul>Footer
    12. 12. Column From Marked <ul><ul><li>Column used on an axis depending on what you mark in a different visualisation </li></ul></ul><ul><ul><ul><li>Used together with details visualisation to provide axis labels </li></ul></ul></ul><ul><ul><ul><ul><li>&quot;pFC &quot; & [DRUG] as [pFC DRUG] </li></ul></ul></ul></ul>Footer
    13. 13. Text Area <ul><ul><li>Extra information on the analysis </li></ul></ul><ul><ul><li>Shortcuts to specific selections and markings </li></ul></ul><ul><ul><li>To improve the overall layout </li></ul></ul>Footer
    14. 14. Using Tags <ul><ul><li>Editable labels </li></ul></ul><ul><ul><ul><li>Use Tag Collection column as the “Labels by” column </li></ul></ul></ul><ul><ul><ul><li>Configure the key columns ! </li></ul></ul></ul>Footer
    15. 15. Simple Structure Viewer <ul><ul><li>Uses the map chart </li></ul></ul><ul><ul><ul><li>WMF image background </li></ul></ul></ul><ul><ul><ul><ul><li>Powerpoint slide saved as WMF </li></ul></ul></ul></ul><ul><ul><ul><li>Auto-zooming details visualisation </li></ul></ul></ul><ul><ul><ul><ul><li>Coordinates of 2 corners in separate data table </li></ul></ul></ul></ul>Footer
    16. 16. Questions? Footer