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Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

This document discusses how advances in genome sequencing and gene editing technologies will impact humans by 2020. Key points include: genomes can now be sequenced for $100, with the goal of sequencing 100,000 genomes by 2020; this data will provide opportunities to understand and construct the human genome; gene editing allows modifying genomes by targeting specific genes, though challenges remain around immune response and safety; gene editing could enhance human traits like strength and endurance through targeting genes like IGF-1 and myostatin.

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Humansin2020,[object Object],Ramez Naam,[object Object],@ramez,[object Object]
Three Ingredients,[object Object]
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Motivation is Medical,[object Object]
Acceptable,[object Object],Human Baseline,[object Object]
?,[object Object],Human Baseline,[object Object],Questionable!,[object Object]
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
External != Internal,[object Object]
?,[object Object],?,[object Object],Human Baseline,[object Object]
The Power to Heal=The Power to Enhance,[object Object]
Our Population is Aging,[object Object]
A Worldwide Phenomenon,[object Object]
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Disability as a Function of Age,[object Object]
Lost With Age,[object Object]
A Very Large Motivator,[object Object]
Order:  Trillions of $’s,[object Object]
Ten Thousand Dollars,[object Object]
One Million Dollars,[object Object]
One Billion Dollars,[object Object]
One Trillion Dollars,[object Object],You Are Here,[object Object]
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
So What?,[object Object]
Opportunity?,[object Object]
Knowledge,[object Object]
Understanding,[object Object]
Human Construction,[object Object]
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Goal:  100,000 Genomes by 2020,[object Object]
2020: $100 Genome,[object Object]
Millions of Genomes Sequenced,[object Object]
Millions of Individual Humans,[object Object]
Every Mammalian Species,[object Object]
Lots of Data to Mine,[object Object]
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
What Will We Find?,[object Object]
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Knowing is Half the Battle,[object Object]
The Other Half is Doing,[object Object]
If the Genome is Digital,[object Object]
Can We Edit It?,[object Object]
Sometimes,[object Object]
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Some Challenges,[object Object]
Immune Response,[object Object]
Cancer (from retroviral vectors),[object Object]
Number of Cells Changed,[object Object]
Progress,[object Object]
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Strength & Endurance: IGF-1, Myostatin, PPAR-Delta,[object Object]
Oxygen Capacity: EPO,[object Object]
“About half the emails I get now are from athletes”,[object Object],       - Gene Therapy Researcher Lee Sweeney,[object Object]
More Provocative Changes are Likely Possible,[object Object]
In Summary,[object Object]
We Are Approaching the Day of the Editable Genome,[object Object]
Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard
Humansin2020,[object Object],Ramez Naam,[object Object],@ramez,[object Object]

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Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

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Editor's Notes

  1. Dawkins: Biology in One Word: Digital
  2. Venter: Most Important Research Tool: The Computer
  3. George Church
  4. Venter, artificial life = Gene Printing
  5. Belgian Blue Bull – mutated form of MyostatinMouse on Lower Right – PPAR-Delta
  6. EeroMantyranta, 1964 cross country skiing gold medalist, had a mutation of his EPO genes that led to greater endurance