Can	
  we	
  extract	
  a	
  mind	
  from	
  a	
  
  plas3c-­‐embedded	
  brain?	
  
         Kenneth	
  Hayworth,	
  PhD
...
Mouse	
  brain




                         4.5mm




                 1.2mm
38nm	
  thick	
  mouse	
  cortex

Cor2cal	
  surface




   Layer	
  2,3	
  cell	
  
   bodies




    Layer	
  4	
  axons...
Automatic Tape-collection Mechanism
Automatic Tape-collection Mechanism
~3mm
30nm	
  stack




     200Sections_30nmCortex_Uncompressed_7fps.avi
FEI	
  DualBeam
Focused	
  Ion	
  Beam	
  +	
  Scanning	
  Electron	
     “Serial	
  Sec;on	
  Scanning	
  Electron	
  Mic...
FIBSEM	
  Stack




         Movie	
  from	
  “Serial	
  Sec;on	
  Scanning	
  Electron	
  
         Microscopy	
  of	
  A...
200	
  –	
  300	
  micron	
  thick	
  sec;on	
  of	
  
         newborn	
  mouse	
  brain




Same	
  thick	
  sec;on	
  w...
2	
  +	
  2	
  =	
  4
www.BrainPreserva3on.org
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard
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Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard

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Ken Hayworth
Can we extract a mind from a plastic-embedded brain?

We now have a good working theory of consciousness – the phenomenal self model (Metzinger 2009), and we have a good understanding of the human cognitive architecture (Anderson 2007) within which this self model is implemented. The key components of this cognitive architecture are declarative memory chunks and productions – thought to be implemented as stable attractors in the neural networks of the cortex and basal ganglia. According to neural network theory, such stable attractors are robustly defined by the synaptic connectivity between neurons. In small pieces of tissue such synaptic connectivity is easily preserved using chemical fixation and embedding in plastic, and it should be relatively easy to adapt these protocols into a surgical procedure performed in hospitals to preserve whole human brains. Such plastic embedded brain tissue can be imaged at the nanometer level using new automated techniques (SBFSEM, FIBSEM, Tape-to-SEM), and we can directly extrapolate these techniques to future ones that will enable all the synaptic connections within a human brain to be mapped allowing a fully accurate simulation of the original preserved mind. In short, we have a complete sketch of how mind uploading will work and we have a mandate to implement emergency brain preservation in hospitals for all who desire access to this future technology.

Kenneth Hayworth, a postdoctoral fellow at Harvard University, is the inventor of several technologies for high-throughput volume imaging of neural circuits at the nanometer scale. He received a PhD in Neuroscience from the University of Southern California for research into how the human visual system encodes spatial relations among objects. Hayworth is a vocal advocate for brain preservation and mind uploading, and runs a website (www.brainpreservation.org) calling for the implementation of an Emergency Glutaraldehyde Perfusion procedure in hospitals, and for the development of a Whole Brain Plastic Embedding procedure which can demonstrate perfect ultrastructure preservation across an entire human brain.

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Can we extract a mind from a plastic-embedded brain? - Kenneth Hayworth - H+ Summit @ Harvard

  1. 1. Can  we  extract  a  mind  from  a   plas3c-­‐embedded  brain?   Kenneth  Hayworth,  PhD June  12,  2010
  2. 2. Mouse  brain 4.5mm 1.2mm
  3. 3. 38nm  thick  mouse  cortex Cor2cal  surface Layer  2,3  cell   bodies Layer  4  axons Images thanks to Bobby Kasthuri, Richard Schalek, Juan Carlos Tapia, Daniel Berger and Jeff Lichtman
  4. 4. Automatic Tape-collection Mechanism
  5. 5. Automatic Tape-collection Mechanism
  6. 6. ~3mm
  7. 7. 30nm  stack 200Sections_30nmCortex_Uncompressed_7fps.avi
  8. 8. FEI  DualBeam Focused  Ion  Beam  +  Scanning  Electron   “Serial  Sec;on  Scanning  Electron  Microscopy   Microscope   of  Adult  Brain  Tissue  Using  Focused  Ion  Beam   Milling”  (KnoD  et  al.  2008  )
  9. 9. FIBSEM  Stack Movie  from  “Serial  Sec;on  Scanning  Electron   Microscopy  of  Adult  Brain  Tissue  Using   Focused  Ion  Beam  Milling”(KnoD  et  al.  2008  )
  10. 10. 200  –  300  micron  thick  sec;on  of   newborn  mouse  brain Same  thick  sec;on  with  blocks  removed  for   ultrathin  sec;oning  and  TEM   reconstruc;on.
  11. 11. 2  +  2  =  4
  12. 12. www.BrainPreserva3on.org

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