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  1. 1. About this lecture <ul><li>Composition of Blood </li></ul><ul><li>Plasma make up and roles </li></ul><ul><li>Various cell types, origin and roles </li></ul><ul><li>Red blood cells, hemoglobin & iron metabolism </li></ul>
  2. 2. Blood Components: Plasma Transports Solutes <ul><li>Water, ions, trace elements </li></ul><ul><li>Gasses: O 2 & CO 2 </li></ul><ul><li>Organic Molecules </li></ul><ul><ul><li>Glucose </li></ul></ul><ul><ul><li>N–wastes </li></ul></ul><ul><ul><li>Proteins </li></ul></ul><ul><ul><li>Antibodies </li></ul></ul><ul><ul><li>Hormones </li></ul></ul>
  3. 3. Blood Components: Plasma Transports Solutes Figure 16-1: Composition of blood
  4. 4. Blood Components: &quot;Blood Count&quot; – % of Each Component Figure 16-2: The blood count
  5. 5. Blood Components: Cells <ul><li>Erythrocytes </li></ul><ul><ul><li>Red Blood Cells (RBC) </li></ul></ul><ul><ul><li>O 2 & CO 2 transport </li></ul></ul><ul><li>White Blood Cells (WBC) </li></ul><ul><ul><li>Immune defense </li></ul></ul><ul><ul><li>Phagocytosis </li></ul></ul><ul><li>Platelets: clotting </li></ul>
  6. 6. Hematopoiesis: Blood Cell Formation <ul><li>Mostly in bone marrow from stem cells </li></ul><ul><li>Rate regulated by cytokines & growth factors </li></ul>
  7. 7. Hematopoiesis: Blood Cell Formation Figure 16-3: Hematopoiesis
  8. 8. Focus on RBCs: Figure 16-5c: Bone marrow
  9. 9. Focus on RBCs: Figure 16-7a, b: Bone marrow
  10. 10. Iron Metabolism: Key to Hemoglobin O 2 Transport Figure 16-8: Iron metabolism
  11. 11. Some Diseases of RBCs and O 2 Transport Table 16-3: Causes of Anemia