Chronic Fatigue causing Virus (HHV-6)Human Herpes Virus 6 linked to ChronicLyme disease:Its Link to Chronic Fatigue Syndrome, Fibromyalgia, Fatigue, andCancerFirst reported in 1986, human herpesvirus 6 (HHV-6) has since become one of the most widespreadmembers of human herpes viruses and comes in two related variants: HHV-6A and HHV-6B. And thoughsimilar, there areclear differences in their epidemiology and pathogenicity.HHV-6B is acquired in early childhood (often in daycare centers) and is responsible for infecting up to90% of most populations during infancy. HHV-6A behaves quite differently as it is generally not seenuntil adulthood. Both versions of the virus can be found in saliva and are presumably spread this way aswell.The HHV-6 virus is of greatest concern to immunocompromised patients. Among those at the greatestrisk of severe HHV-6 complications are those who have undergoneorgan or bone marrow transplants orwho are HIV positive and those with chronic Lyme disease.
How Does HHV-6 Work?HHV-6 is known to attack specific cells including but not limited to CD 4 lymphocytes, NKTs,oligodedrocytes, CD8 cells, and microglial cells. Moreover, this virus is immune suppressive and alsoactivates other viruses in the process. While HHV-6 can remain latent for long periods of time, it canreactivate and cause infection quickly. The virus can lie in wait in the salivary glands, kidneys, or brainuntil reactivated.CFS, Fibromyalgia and AutoimmuneDisease Symptoms Linked to HHV-6Maladies resultant of HHV-6 are many, and includes the idiopathic illness Chronic Fatigue Syndrome(CFS). Patients who suffer with CFS potentially face immunologic abnormalities and neurologicproblems. It was observed in one study that 30 percent of CFS patients tested positive for HHV-6 andafter a series of follow-up tests, it was discovered that an additional 20-40 percent were also positiveafter initially showing no trace of the virus. The obvious association between HHV-6 and CFS reaffirms amuch broader link between infection and chronic disease.HHV-6 is one of the infections found invirtuallyall Chronic Lyme Disease patients – a chief contributor to fatigue and other neurological symptoms.Antibiotics do not affect this or other herpetic viruses.HHV-6 as a Potential Causative toChronic Lyme Disease, Parkinson’s, andAlzheimer’sNeurodegenerative diseases such as Alzheimers, Parkinson’s, and Multiple Sclerosis (MS) lookincreasingly appear to be catalyzed by viral infections. More specifically, neurotropic virus HHV-6 hasbeen clinically shown to be tied to many neurologic problems including encephalitis, mesial temporallobe epilepsy, and many others.Nevertheless, HHV-6’s route into the central nervous system remains inconclusive. However, amongvarious brain regions examined, the highest frequency of HHV-6 DNA can be routinely identified in theolfactory bulb/tract region. While further tests must be conducted, the olfactory pathway does seemlikely as at least one pathway for HHV-6 to move into the CNS.HHV-6 Infection: Its Role in One Child’s
Acute Lymphoblastic LeukemiaIn one case, a child’s acute lymphoblastic leukemia came only two months after an HHV-6 infection wasdetected.Evidence continues to mount that suggests viral infections could play a major causative role insome childhood leukemia.HHV-6 Attacks p53 giving rise to cancersProtein p53 regulates the cell cycle and thereby serves as an invaluable tumor suppressor – one thatplays a vital role in helping the body prevent cancer development and growth.How does p53 work?p53 snaps into action when it detects DNA damage. Typically low levels of the protein rise immediately,initiating protective measures by binding to sites in the genome and halting cell division until thedamage can be repaired. Should the damage have progressed too far for repair, p53 will triggerapoptosis, or cell self-destruction, eradicating the problem swiftly and completely.HHV-6 Viral Co-infection of ChronicLyme Disease: Immunity and CancerImplicationsRegulatory influences in cell proliferation, studies show, can be altered definitively by viral infections.HHV-6 is a common perpetrator for such significant and impactful changes drawing additional attentionfrom researchers across the globe.Envita’s Fully Engages Chronic LymeDisease Complex and Its DangerousHHV-6 Co-infectionEnvita clinical experience in testing chronic Lyme disease patients shows many have activated forms ofco-infection viruses such as HHV-6. That means that many Lyme sufferers are likely carriers of thisinfection as well as others. Biofilm communities and immunodeficiencies could make HHV-6 and othervirus actively replicate.
Envita employs only the most advanced diagnostic tools to test for a variety of infections like HHV-6, andexamine whether it is a causative factor for other maladies, such as Chronic Fatigue Syndrome. Weutilize the most effective therapies from around the world to modulate and boost immune function inpatients suffering with HHV-6 or those who are immunocompromised and at risk of contracting it.References: • Abel-Haq, N.M. and Asmar BI. Human herpesvirus 6 (HHV-6) infection. Indian J. Pediatr. 2004 Jan; 71(1): 89-96 • Secchiero, Paola, et al. HHV-6 Infection in Immunocompromised Patients. Infections in Medicine.2005; 22(3). • Wisconsin Viral Research Group, Ltd. wisconsinlab.com • Institute of Human Virology, University of Maryland, Baltimore, Baltimore, MD, (citations for the above) • http://www.medicalnewstoday.com/releases/112548.php this source to site • Seror E, DeVillartay P, Leverger G, Lenoir G. SourceService de pédiatriegénérale, hôpital Necker- Enfants-Malades, AP-HP, 149, rue de Sèvres, 75743 Paris cedex 15, France • Dr. David Bell in 2008 on research by Dr. L. Flammand to citation Source Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. • Journal of the American Society of Hematology citations for above