Cancer connection chronic lyme disease co-infection ehrlichiosis often ignored


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Cancer connection chronic lyme disease co-infection ehrlichiosis often ignored

  1. 1. Cancer Connection -Chronic Lyme DiseaseCo-infection Ehrlichiosis often ignored:Cancer Connection -Chronic Lyme DiseaseCo-infection Ehrlichiosis often ignored:Because Ehrlichiosis is rarely tested for, chronic Ehrlichiosis patients are widelymisdiagnosed with autoimmune disorders or other chronic diseases with similarsymptomologies. Symptoms of associated with Ehrlichiosis can include high fever,headache, chills, in addition to muscular aches and pains. These closely mimic those ofother tick-borne diseases.Key Points on EhrlichiosisEhrlichiosis is caused by rickettsial-type (specific bacteria) organisms and comes in twospecific forms:  Human Monocytic Ehrlichiosis (HME)  Human Granulocytic Ehrlichiosis (HGE)The bite of the Lone Star tick (Amblyomma Americanum) bite is said to be the origin ofHME, while HGE has been linked to both Deer tick (Ixodes Scapularis) and Westernblacklegged tick (Ixodes Pacificus) bites. The dog tick (Dermacentor Variabilis) is knownto transmit both HME and HE varieties of Ehrlichiosis.
  2. 2. The ticks that pass Ehrlichiosis are also Lyme disease transmitters so those whocontract the disease should immediately be tested for Lyme as well – the likelihood isgreat.Can Ehrlichiosis be Spread in Blood Transfusion? Yes!Unlike some other blood-borne pathogens, Ehrlichiosis and other tick borne infectionscan be passed on through transfusions. This happens as the demand for blood supplylimits testing to hepatitis and HIV. Lyme and its co-infections are suspected to exist ingreat numbers among donors and their resultant transfusion supplies.Ehrlichiosis – Creating Central Nervous System ProblemsIn routine central nervous system (CNS) radiological studies, analyses of cerebrospinalfluid (CSF) samples are seldom pursued. Typically, such tests are prompted only whenprimary care physicians detect specific symptoms or signs that tip the need for moreinformation. In such circumstance when CSF samples were examined (in 15 of 57patients,) 8 of the 15 were found abnormal. The most common abnormalities foundamong the abnormal 15 percent were lymphocytic pleocytosis and elevated proteinlevels.Ehrlichiosis – Cancer ConnectionThere are four bacteria known to survive and propagate within human neutrophils andtheir bone marrow origins - Ehrlichiosis is one of them.This tick-transmitted rickettsialpathogen, anaplasma phagocytophilum, is a causative agent of human granulocyticanaplasmosis and is found in the direct family line of Ehrlichiosis.About 70 percent of all white blood cells are neutrophils – cells considered to beunsuitable hosts by intracellular bacteria as they are short-lived and serve as primarydefense cells, armed with significant antimicrobial apparatus.A. phagocytophilum infection can alter neutrophil functions and result in clinical disease.Moreover, this infection can inhibit or retard apoptosis, oxidative burst, andphagocytosis, while activating degranulation and cytokine/chemokine production – oftenleading to cancer. At this time it is impossible to say how many infections are cancercausatives, but this one certainly seems to have a link suggesting that leukemia andother lymphatic cancers are catalyzed by epigenetic shifts resultant of Ehrlichiosis.Choi KS, Grab DJ, Dumler JS (2004) Anaplasma phagocytophilum infection induces protracted neutrophildegranulation. Infect Immun 72: 3680–3683.Ehrlichiosis and Immune system problems in Patients:The zoonotic illness Ehrlichiosis is caused by Ehrlichia species - bacteria that aredecidedly pleomorphic, intracellular, rickettsia-like organisms.[2-4] Ehrlichia present a
  3. 3. clinical spectrum, or symptomology that can vary from a mild, influenza-like illness, to afulminant sepsis syndrome. Typically, we find that Ehrlichiosis is self-limiting and notfatal with death rates in large, unselected series ranging from 1 to 8 percent [3,6-8] -contrasting sharply with the high death rate of patients suffering with the disease whowere already immunocompromised.Emerging Infectious Diseases. 2002;8(3) © 2002 Centers for Disease Control and Prevention(CDC)The Central Nervous System Invader, EhrlichiosisNeurologic manifestations effect up to 20 percent of Ehrlichiosis patients who can sufferwith a spectrum of symptoms including everything from confusion to frank meningitis. Inone recent case, a patient dealt with persistent obundation and delirium even after feverhas dissipated post-doxycycline administration.Ehrlichia should be considered in the event that headache and confusion come withpancytopenia and transaminase elevation - particularly if the patient has had potentialtick exposures.It should not be surprising that an Ehrlichiosis diagnosis is often because of itsnonspecific clinical and laboratory manifestations. Among patients who were previouslyimmunocompromised, diagnosis can be further delayed because the search foropportunistic infections may further obscure the recognition that Ehrlichia is present.Empiric antimicrobial regimens that are often administered for suspected cryptogenicbacterial and fungal sepsis to immunocompromised subjects rarely include drugseffective against Ehrlichia.Emerging Infectious Diseases. 2002;8(3) © 2002 Centers for Disease Control andPrevention (CDC)Considering a Diagnosing EhrlichiosisFor any patient with potential tick exposure in an endemic area who is suffering withfever, transaminase elevations, new-onset thrombocytopenia, or leucopenia, anEhrlichiosis diagnosis should be considered. For those who could be categorized asimmunocompromised, the clinical manifestations are far more severe and can includeneurologic deterioration, multiorgan failure, and even a TTP-like illness. Moreover, thedoxycycline therapy response could be delayed. The use of PCR for confirmatorydiagnosis and early empiric therapy can be life-saving.Emerging Infectious Diseases. 2002;8(3) © 2002 Centers for Disease Control and Prevention (CDC) The Immune System is vitalA host’s best defense against rickettsial infection is its cellular immunity. Inf fact,Ehrlichia clearance from peripheral blood in patients with HGE comes from elevatedlevels of interferon gamma.
  4. 4. In a recent mouse model of Ehrliciosis, results showed that immunocompromised micesuffered with persistent infection. Most of them eventually did succumb to the disease. Itshould be pointed out that cellular immunity, whether begotten of immunosuppressivetherapies or underlying disease, can compromise recovery and result in more severedisease and oftentimes death.Emerging Infectious Diseases. 2002;8(3) © 2002 Centers for Disease Control and Prevention (CDC)Welcome to Envita Medical CentersEhrlichia is a regular participant in the Lyme disease Complex of infections. Patientsmust be made aware of all infections, toxins, and heavy metals involved in theirdisease. Moreover, in chronic Ehrlichia cases, patient treatments must incorporatemuch higher doses of antibiotics than typically prescribed; something that Envita takesgreat care to administer. We invite those interested in state-of-the-art treatment tocontact Envita Medical Centers - a world leader in Lyme disease treatment.