Basic pharmacology. hamza


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Basic pharmacology. hamza

  1. 1. Hamza HemalRadiant Pharmaceuticals Ltd.
  2. 2. Brand Name•Trade name•Given by the Manufacturer company•To distinguish products from each other.Example:ACOS (Radiant)ZIMAX ( Square)
  3. 3. Generic NameOfficial medical name for the active ingredient of the medicine.Example:AzithromycinEsomeprazole Hamza
  4. 4. API• Active Pharmaceutical Ingredient• Any component that provides pharmacological activity Hamza
  5. 5. Dosage Form• A dosage form is the physical form in which a drug is produced and dispensed.• Example: – Tablet, – Capsule, – PFS (Powder for Suspension) – Injection Hamza
  6. 6. StrengthAmount of the active ingredient is present in each dosage. Example: 500mg Tablet 200mg/5ml PFS Hamza
  7. 7. Brand Name Strength Generic NameDosageForm Hamza
  8. 8. COGS• Cost of Goods sold• Raw material + Packaging Material + Utility cost + Per head costTP•Trade Price•COGS + ProfitInvoice PriceTP+ VATMRPMaximum Retail Price HamzaTP+ VAT+ Chemist Profit
  9. 9. Pharmacodynamicswhat the drug does to the body Pharmacokineticswhat the body does to the drug Hamza
  10. 10. Bioavailability• Amount of drug that present in blood after administration.• INTRAVENOUS Route- Bioavaiability 100% Hamza
  11. 11. Peak Plasma concentration, CmaxThe maximum plasma concentration of the drug achieved in blood after a doseTmaxThe time when themaximum plasmaconcentration (Cmax) isreached. Hamza
  12. 12. Plasma half life/Elimination Half Life, T1/2Time necessary for the drug to be reduced to half of its plasma concentration 11 10 9 8 7 6 5 4 3 2 1 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 T1/2
  13. 13. Area Under the Curve (AUC)The area under the plot of plasma concentration of drug against time after drug administration.
  14. 14. MEC• Minimum Effective Concentration• The smallest concentration of a drug that will induce the desired pharmacological effect MIC• Minimum inhibitory concentration• MIC is defined as the minimum concentration of antibiotic which will inhibit the growth of the microorganism Hamza
  15. 15. Hamza
  16. 16. First pass effect/ First pass metabolismThe removal of a drug by the liver, before the drug has become available for use, is called the first pass effect. Hamza
  17. 17. EfficacyPower or capacity to produce a desired effectPotencyAmount of drug required to produce a particular responseAffinity:Tendency of a drug to combine with receptor Hamza
  18. 18. Therapeutic doseThe dose that may be required to produce a desired effect.Sub Therapeutic doseIndicating a dosage of a drug, less than the amount required for a therapeutic effect. Hamza
  19. 19. BacteriostaticAntibiotics that inhibit the growth or reproduction of bacteriaBactericidalAntibiotic that kills the bacteria Hamza
  20. 20. Hamza