Neurobehavioral risk factors
• Degree of metabolic control.
• Adults in poor control manifest
subtle changes on measures of
• Poor sophisticated information-
Neurobehavioral risk factors in
• Age of onset at diagnosis .
• Occurrence of school room-related
• lower than expected on verbal IQ tests and
school achievement tests.
• severe episodes of hypoglycemia--is known
to disrupt functioning in diabetic subjects
of any age
Prevalence of cognitive
• Dementia estimated from the
screening tests were high
• Activities of daily living (ADL)
was reported by 53% of the
• Problems included urinary and
faecal incontinence .
Cognitive consequences and
associated brain correlates
• Presence of microvascular
• Occurrence of severe
• Poor metabolic control.
• Depression appears to increase the risk of
developing diabetes by approximately 23%
in younger adults.
• Depression reported in DM by 14.2%.
but 50.2% of the remainder reported one or
more depressive symptoms.
Antidepressants and Diabetes
• If high risk for getting type 2 diabetes,
antidepressant drugs can boost that risk.
• Patients on antidepressants had a two-to-
three times greater risk of getting type 2
• Depression causes diabetes, or vice versa,
has been unresolved.
• The antidepressant may reduce the risk
of recurrent depression and increase the
period of time between episodes of
depression in patients with diabetes
* Increased risk of diabetes in
patients taking AAPs.
• MONITORING RECOMMENDATIONS
1. Monitoring weight.
2. Fasting blood glucose.
3. Blood pressure.