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Development of spinal cord

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Development of spinal cord

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Development of spinal cord

  1. 1. EMBRYOLOGY By; RazaRehman, 152 Maria Ilyas, 148 Isfandyar; 156 S p i n a l C o r d
  2. 2. Neural Tube ■ Arises from the ectoderm overlying the notochord ■ Gives rise to the brain and spinal cord
  3. 3. Neural Tube Formation ■ The neural plate folds to form neural groove with prominent neural folds ■ The neural folds approach each other with deepening of the neural groove
  4. 4. Neural Tube Formation ■ The neural folds fuse and a neural tube is formed ■ The tube, then, separates from the overlying ectoderm
  5. 5. Development of Spinal Cord Nueroepithilial cells form: •Ventricular zone - Ependymal cells •Intermediate zone - Form from neuroblasts •Marginal zone - Forms white matter
  6. 6. Development of the Spinal Cord ■ The cells of the neural tube migrate to form the mantle layer o f gray matter which differentiates into Q An alar plate, mostly sensory neurons Q A basal plate, mostly motor neurons. Q Separated by sulcuc limitans
  7. 7. Development of the Spinal Cord ■ The cells of the mantle layer have axons which collect in the marginal layer o f white matter
  8. 8. Meninges •Dura mater -External layer •Pia arachnoid - Separated by arachnoid trabeculae Develop from neural crest cells
  9. 9. Neural Crest Cells ■ Originate from cells of neural folds. ■ Lie between the neural tube and surface ectoderm.
  10. 10. Neural Crest Cells ■ They, then, migrate to new locations; gives many derivatives G A M E S ■ Ganglion cells (DRG, Cranial sensory, Autonomic) ■ Arachnoid and pia maters ■ Melanocytes, Mesenchyme of the pharyngeal arches ■ Enteric ganglia ■ Schwann cells, Suprarenal medulla cells

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