Normal Pain Sensation
In the presence of
What’s the need to inhibit synthesis of “prostaglandins”….?
Actions of PROSTAGLANDINS Actions Of ASPIRIN
1. Sensitize spinal nerves to pain.
2. Regulate inflammatory mediation.
3. Act on thermoregulation centers in
hypothalamus to produce fever.
4. Act on glomerular cells to increase
5. Act on parietal cells in stomach to
inhibit acid secretion.
rate, can cause Renal
can cause GI-
Thromboxane causes platelet aggregation. Aspirin prevents blood clot formation by
inhibiting thromboxane synthesis. Therefore ASPIRIN is used by cardiac patients to prevent
heart attack. These patients have a slogan “An Aspirin A Day, Keeps The Doctor Away”.
Aspirin toxicity or SALICYLISM is acute or
chronic poisoning with overdose of aspirin.
o10-30 mg/d L: Therapeutic level (No
Poisoning)o>30 mg/d L : 1st
Sign of toxicity
o if >100mg/d L: Early hemodialysis should be considered
•Uncoated tabs (therapeutic doses): 15-20 mins.
• Enteric coated tabs: 18-24 hours
children or elderly
1. Suicidal Attempt by
adults or teenagers.
August 12, 1977
Theodore Hirschberg vs. State Of
New York Court Of Claims
•Examination revealed toxicity
symptomology but doctor
•No diagnostic tests done.
•No physical examination.
•Physician thought his
colleague had seen the patient.
•Gave patient anti-psychotic
and put him on suicide alert.
•Later investigations revealed
that the doctor was not
$ 35,000/-•Suicide Attempt….why?
•Because the person faces
Symotomology does reveal;
FEVER, TINNITUS, NAUSEA,
• Respiratory Alkalosis
Krebs Cycle and
Glucose cannot be
to synthesize more
of GLUCOSE from
plasma by cells
as alternate energy
Results in respiratory alkalosis
as compensation for metabolic