Lecture 1

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Lecture 1

  1. 1. Dr. Moona Mehboob Khan Ph.D (Pharmaceutical Chemistry) Assistant Professor D.C.O.P, Dow University of Health Sciences 1
  2. 2. Course Outline Introduction to Pharm chem & basic concepts Electrophillic & nucleophillc substitution reactions Orientations Organic reactions Carbonium ion Carbanion Free radicals Different functional groups 2
  3. 3. Learning Objectives Basic concept regarding pharmaceutical chemistry in health care system. 3
  4. 4. Introduction Introduction to Pharmaceutical chemistry Classification of pharm chem. Nomenclature of organic pharmaceutical compounds. 4
  5. 5. Basic concepts in Pharm chem Conjugation & hyperconjugation Steric effect Inductive effect Mesomeric effect Hydrogen bonding Theory of resonance Effect of structure on reactivity of compounds Tautomerization of carbonyl compounds 5
  6. 6. Carbonium Ion rearangement & their stability Pinacolone Wagner-Merrwein Wolf, Hofman & Beckmann rearrangement 6
  7. 7. Carbanions & their stability Condensation reactions Aldol condensation Favorskii rearrangement Witting reactions 7
  8. 8. Functional Groups Alcohols & phenols Ethers Ketones & aldehydes Carboxyllic acids Esters Amines, amide & imides Anilines Lactum & lactones Diazonium salts 8
  9. 9. Pharmaceutical chemistry What is science? What is chemistry? What is organic chemistry? What is Pharmacy? What is Pharmaceutical chemistry? 9
  10. 10. Pharmaceutical Chemistry-The science that deals with the discovery or design of new therapeutic chemicals and the development of these chemicals into useful medicine. 10
  11. 11. Medicine A compound that interacts with a biological system, and produces a biological response (ideally desired and positive). ORs According to world health organization medicine is defined as “ A medicine is any substance or product that is used to modify pathalogical states for benefit of recipient”. These compounds may be organic & inorganic 11
  12. 12. Types of Pharm.chem Organic Inorganic Physical chemistry Analytical chemistry Synthetic chemistry Instrumental chemistry Medicinal chemistry Bio-stats Maths 12
  13. 13. References Organic chemistry by IL Finar Organic chemistry by Solomons & Fryhle Organic chemistry by Brown Foote Inversion 13

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