Cornelius developed world

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Cornelius developed world

  1. 1. Improving Human Nutrition with Biotechnology-Derived Soybean Traits Biofortification Conference November 9, 2010 Joe Cornelius Monsanto Company 1
  2. 2. Monsanto Confidential The World Produces 133 MMT of Vegetable Oils 83% is Consumed for Food China India EU USA Indonesia Brazil Russia Japan Mexico Turkey Iran Malaysia Argentina Canada Thailand Ukraine Australia Philippin… 0 2 4 6 8 10 12 14 16 18 20 2009 Global Vegetable Oil Consumption in Food Was 110 MMT Palm 47 MMT 35% Soybean 40 MMT 30% Rapeseed 19 MMT 14% Sunflower, 11 Coconut, 3 Cotton, 5 Peanut, 5Corn, 2 2009 Global Vegetable Oil Production 2
  3. 3. Improving Soybean Oil Composition Provides Opportunity to Positively Impact US Diets • Soybean oil is a major component of US dietary oils & fats • For fried foods, baked goods, and snack products, soybean oil is hydrogenated to increase shelf life and flavor stability • Partial hydrogenation process creates trans fats U.S. Edible Oil Consumption (27 Billion lbs) Soybean (65%) (16.6 B Lbs) Coconut Corn Cottonseed Lard Olive Palm Palm Kernel Peanut Canola Safflower Sunflower Tallow, edible 2008 Soya & Oilseed Bluebook
  4. 4. Monsanto Confidential Mono- Unsaturated (Oleic) Saturated Fatty Acid (Palmitic) Nutritional Recommendations and Actual Intake 0 2 4 6 8 10 12 14 16 Dietary Recommendations Actual Consumption Poly- Unsaturated (Omega 3/6) Trans Fat Hydrogenation (Linolenic) (% of energy) We consume too little We consume too much Low as possible Vegetable Oil Consumption Impacts Nutrition 4
  5. 5. Technology Platforms Enable Innovation from Gene to Seed to Food Genomics Food & Nutrition Crop Analytics Molecular Breeding Conventional Breeding Biotechnology BREEDING BIOTECHNOLOGY Crop Germplasm Improved Seeds Two R&D pathways linked by shared tools 5Monsanto Confidential5
  6. 6. Vistive® Gold Soybean Oil High Stability, Low Saturated Fat, Zero Trans Fat Over 12 years development with Processors, Food Co’s and Nutrition Community OUTPUT TRAIT PRODUCT CONCEPT: • Consumer health (reduce trans fat & saturated fat) • Food product performance (increase oxidative stability) • Sustainable local source (renewable feedstock - food & industrial)) Soybean Oil - Fatty Acid Composition (%) 16:0 Palmitic 18:0 Stearic 18:1 Oleic 18:2 Linoleic 18:3 Linolenic Commodity Soybean Oil 11 4 20 55 8 Vistive Gold Soybean Oil* 3 3 74 15 < 3.5 Reduce Saturates (Total 60%, Palm 73%) Zero TransIncrease StabilityBenefits Discovery Phase 1 Proof of Concept Phase 2 Early Development Phase 3 Adv. Development Phase 4 Pre-Launch Launch Monsanto Company Confidential 6 NEW 2010 Dietary Guidelines: Reduce saturated fat from 10% en to 7% en 6 * Target fatty acid composition; final product specification range is contingent upon variety development and environment 6
  7. 7. 18:0 Stearic Saturate 18:1 Oleic Mono 18:2 Linoleic Omega 6 FATB Thioesterase 16:0 Palmitic Saturate 18:3 Linolenic Omega 3 FAD2 Δ-12 Desaturase FAD3 Δ-15 Desaturase Δ-9 Desaturase Fatty acid synthesis Palmitate (in trigly- cerides) CONVENTIONAL NOTE: relative sizes for illustrative purposes only- not proportional to actual composition Biotechnology + Breeding Enhance Soybean Oil Reduces Saturated Fatty Acids Increase Monounsaturates Reduces Polyunsaturates 18:0 Stearic Saturate 18:1 Oleic Mono 18:2 Linoleic Omega 6 FATB Thioesterase 16:0 Palmitic Saturate 18:3 Linolenic Omega 3 Conventional Breeding VISTIVE® GOLD Reduces 18:3, enabling frying without hydrogenation Activity Reduced- Biotech (RNAi) FAD2 Δ-12 Desaturase FAD3 Δ-15 Desaturase
  8. 8. Vistive Gold Technology in the Seed Lowers Saturated Fat in a Soybean Acre Each acre of Vistive Gold Soybeans reduces: •Saturated Fat 60% •Palmitic Acid 75% 0 10 20 30 40 50 60 70 80 Commodity Soy 15% Sat Fat Palmitic Palmitic Stearic Stearic LbsofSaturatedFat/Acre Vistive Gold Soy 6% Sat Fat Average annual U.S. per capita consumption of soybean oil is 54 lbs; Average U.S. lifespan is 77.7 years Monsanto Confidential Over a persons lifetime Vistive Gold could reduce saturated fat intake 377 LBS 8
  9. 9. Vistive Gold Technology in the Seed Increases Soybean Oil Fry Life 77% Commodity Soybean Acre 0 10 20 30 40 50 60 70 80 90 100 51 Hrs Commodity Oil Fry Life 90 Hrs Vistive Gold Oil Fry Life HrsofFryLifeinFoodApplication Vistive Gold Soybean Acre Monsanto Confidential French Fries and Fried Chicken 9
  10. 10. Nutrition Facts Serving Size 114 g Amount Per Serving Calories 384 Calories from Fat 183 % daily Value* Total Fat 20g 31% Saturated Fat 2.5g Trans Fat 0g Nutrition Facts Serving Size 114 g Amount Per Serving Calories 384 Calories from Fat 183 % daily Value* Total Fat 20g 31% Saturated Fat 4g Trans Fat 1g French Fry in Partial Hydrogenated Oil Vistive Gold Delivers Consumer Nutrition Benefit • Vistive oil reduced saturated fat 43% and trans fat 98% in french fries • Vistive oil enables Zero Trans Fat on nutrition facts label • Food Co’s striving for “Clean Label’s” (no trans-fat, no PHSBO, low saturated fat) 10 10 French Fry Study French Fry in Vistive Gold Oil 0 5 10 15 20 25 30 35 40 Vistive GoldHydrogenated Source: 2009, Merlin Development and Monsanto Sat Fat 23.4% Trans Fat 15.7% Trans 0.3% Sat 13.2% Percent % Trans & Saturated Fat in French Fries 39.1% 13.5% Monsanto Confidential
  11. 11. Soybean Oil - Fatty Acid Composition (%) 16:0 Palmitic 18:0 Stearic 18:1 Oleic 18:2 Linoleic 18:3 Linolenic 18:4ω3 Stearidonic Commodity Soy 11 4 24 52 8 0 SDA Omega 3 Soy* 11 4 20 24 10 20 Soymega Soybean Oil for Food (SDA Omega-3 Enriched Soybeans) Over 12 years development with Processors, Food Co’s and Nutrition Community OUTPUT TRAIT PRODUCT CONCEPT: • Consumer nutrition benefit (bioactive omega 3 – heart health) • Improve food product performance (taste and shelf life) • Sustainable source of omega 3 in food (renewable supply – non marine) Increase Omega-3 Discovery Phase 1 Proof of Concept Phase 2 Early Development Phase 3 Adv. Development Phase 4 Pre-Launch Launch Monsanto Company Confidential TM 11 * Target fatty acid composition; final product specification range is contingent upon variety development and environment
  12. 12. SDA-Omega 3 Soybean Oil a Better Solution Dietary EPA has been demonstrated in clinical trials to benefit heart health* * Yokoyama et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised openlabel, blinded endpoint analysis. Lancet 2007; 369: 1090–98 Algae Produce EPA Marine Route to Omega 3 in Human Diet is via Algae and Fish Oil 20:5 EPA Omega 3 18:1 Oleic Mono 18:2 Linoleic Omega 6 18:3 ALA Omega 3 18:4 SDA Omega 3 20:5 EPA Omega 3 20:5 EPA Omega 3 Fish consume algae and deposit EPA Humans consume fish and deposit EPA Rate limiting step is ALA conversion to SDA in fish and mammals 18:1 Oleic Mono 18:2 Linoleic Omega 6 18:3 ALA Omega 3 18:4 SDA Omega 3 + Delta-15 desaturase + Delta-6 desaturase Soybeans Produce SDA Biotech Route to Omega 3 in Human Diet is via Soybean Oil (overcomes rate limiting step) 20:5 SDA Omega 3 A wide variety of foods made with SDA soy oil 20:5 EPA Omega 3 Humans consume good tasting SDA foods and produce their own EPA 12 Monsanto Confidential
  13. 13. Monsanto Confidential SDA Omega-3 Soybean Oil Clinical Study Confirms Heart Health Benefit 0 0.2 0.4 0.6 0.8 1 1.2 1.4 %EPAINREDBLOODCELLS Control 12Weeks Control 12Weeks Control 12Weeks Conventional Soy Oil Diet EPA Oil Control Diet SDA Soy Oil Diet * * *Per protocol population of 157 subjects; p<0.001 compared to soy oil control; SDA and EPA not different p=0.101 Presented at: American Heart Association Scientific Sessions Nov. 14, 2009 by Dr. William Harris •SDA is GRAS (Generally Recognized As Safe) •SDA diet more than doubles heart healthy EPA levels compared to commodity soy •In addition, SDA diet exhibited a significant reduction in triglycerides • 26-30% reduction versus control subjects with high baseline triglycerides CLINICAL STUDY RESULTS DEMONSTRATE SDA CONVERSION TO HEART HEALTHY EPA 13 Mean (+ SEM) for per protocol population of 157 subjects •p<0.001 compared to soy oil control; delta for SDA and EPA not different p=0.101; ANCOVA 13
  14. 14. Soymega SDA is Compatible with Food Systems 14 Monsanto Confidential Soymega flavor profile outperforms alternative sources of Omega-3 3.5 3.5 4.0 5.0 5.0 7.5 Control Soy SDA Soy Flax Algal Fish Encapsulated Fish 0-15 Scale =National Food Laboratory. Nut and Berry Granola Bar Sensory Results. July 2008. Low Score = Better Taste! Granola Bar Shelf Life Results Baking Breads Muffins Cookies/Crackers Pastries/Cakes Baked Cereal Bars Snack Foods Granola/Cereal Bars Nutritional Bars Snacks Confectionery Prepared Foods Processed Meats Processed Fish Entrees/Sides Soups/Sauces Pet Foods Beverages Soy Milk/Smoothies Fruit Juices/Drinks Vegetable Juices/Drinks Enhanced Waters Dairy Products Dairy Drinks Yogurt/Yogurt Drinks Cheese Products Sour Cream/Dips Ice Cream/Frozen Desserts Non Dairy Creamers Oil Based Foods Margarine/Spreads Shortenings Mayonnaise Salad Dressings Peanut Butter Broad Range of Food Applications Excellent Stability and Clean Neutral Flavor
  15. 15. * Each salmon icon represents 100 servings of fish Omega-3 Soybeans a Path to Sustainable Supply Just one acre of Omega-3 SDA- enriched soybeans is equal to ~10,000, 3 oz. servings of salmon Monsanto Company Confidential 151515
  16. 16. Monsanto Confidential Summary: Improving Human Nutrition with Biotechnology-Derived Soybean Traits 2010 Dietary Guidelines Recommendations • Avoid industrial trans fat • Substitute with MUFA and PUFA • Reduce saturated fat in diet • Reduce to less than 7% en. • Substitute with MUFA and PUFA • Consume LC sources of Omega-3 • Two 4 oz. servings of fatty fish/week • Average of 250mg LC PUFA/week 16 16 Soymega™ SDA Omega-3 Soybean Oil Vistive® Gold Low Saturate High Oleic Low Linolenic Soybean Oil

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