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Rudy Guerra, PhD Department of Statistics, Rice University

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Statistical Genetics <ul><li>Heritability - phenotype caused in part by genes </li></ul><ul><li>Genotype-phenotype correlations </li></ul><ul><li>Genetic Linkage (family studies) </li></ul><ul><li>Linkage disequilibrium (association) </li></ul><ul><li>- Population based samples </li></ul><ul><li>Genes and environment </li></ul><ul><li>Genome scans </li></ul>Problems center on identifying and characterizing associations between genes and phenotypes (diseases, cholesterol, plant height).

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Bioinformatics: The New Era The National Center for Biotechnology Information (2001) Bioinformatics is the field of science in which biology , computer science , and information technology merge into a single discipline. There are three important sub-disciplines within bioinformatics: the development of new algorithms and statistics with which to assess relationships among members of large data sets ; the analysis and interpretation of various types of data including nucleotide and amino acid sequences, protein domains, and protein structures; and the development and implementation of tools that enable efficient access and management of different types of information.&quot;

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Hot spots Block

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Microarray Corner of 2-sample cDNA slide Corner of Affymetrix Human chip

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Areas of significant correlation on chr 4

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Down Syndrome (Trisomy 21)

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DNA copy number profiles of 57 medulloblastomas based on SNP array Tumor Chromosome 6 7 17 1 22 Gain Loss

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Rice Statistics Department: Statistical Genetics & Bioinformatics Major Research Components of Research Rudy Guerra Dennis Cox Marek Kimmel Javier Rojo Marina Vannucci Collaborators Applications Intra-department Cancer, heart disease, metabolic syndrome, MD Anderson, BCM-TCH genomic disorders, obesity, cholesterol