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Selenium compounds boost immune system to fight against cancer

Selenium compounds boost immune system to fight against cancer

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Selenium compounds boost immune system to fight against cancer

  1. 1. Selenium CompoundS booSt immune SyStem to fight againSt CanCer
  2. 2. Chemical element Symbol -- Se Nonmetal In small amounts -- key role in metabolism and also anti-oxidant properties Too much selenium -- toxic to the body
  3. 3. From decades – Garlic and some other vegetables – anticancer Researchers found some foods Anticancer properties Contain some natural selenium
  4. 4. Prostate CanCer
  5. 5. MelanoMa
  6. 6. leukeMia
  7. 7. Modify the immune response Modify the immune response and fight cancers like and fight cancers like melanoma, prostate cancer and certain types of leukaemia melanoma, prostate cancer and certain types of leukaemia
  8. 8. Immune system is designed to remove things not normally found in the body. Cells undergoing change, e.g. precursors of cancer cells, are therefore normally recognized and removed by the immune system. Unfortunately, the different cancer cells contain mechanisms that block the immune system's ability to recognize them, allowing them to freely continue cancer development.
  9. 9. Continue…. Certain cancer cells over express immunostimulatory molecules in liquid form  Such over-stimulation -- negative impact Researchers -- found a way to weaken this effect through selenium
  10. 10. Professor Søren Skov, Department of Veterinary Disease Biology, University of Copenhagen “You can say that the stimulating molecules over-activate the immune system and cause it to collapse, and we are, of course, interested in blocking this mechanism. We have now shown that certain selenium compounds, which are naturally found in, e.g., garlic and broccoli, effectively block the special immunostimulatory molecule that plays a serious role for aggressive cancers such as melanoma, prostate cancer and certain types of leukemia"
  11. 11. Different Researchers Said, “For decades, selenium research has been focused on the identification of active metabolites, which are crucial for selenium chemoprevention of cancer. In this context, the metabolite methylselenol (CH3SeH) is known for its action to selectively kill transformed cells through mechanisms that include increased formation of reactive oxygen species, induction of DNA damage, triggering of apoptosis, and inhibition of angiogenesis"
  12. 12. In this study, the researchers -- focused on NGK2D ligands Eight variants one in particular has caught the researchers' attention, because it assumes liquid form Molecular dissolution that causes serious problems, once the cancer is raging. Entire bloodstream – infected Molecule -- marker of serious illness
  13. 13. Professor Søren Skov, Department of Veterinary Disease Biology, University of Copenhagen "Molecules (Ligands) are found both on the surface of the cancer cells and dissolved in the blood of the affected person. We are now able to show that selenium compounds appear to have a very beneficial effect when it comes to neutralizing the special variant of the NGK2D ligand -- both in soluble form and when the molecule is placed on the cell surface"
  14. 14. The researchers are constantly learning more about the disease mechanisms causing aggressive cancers in the skin, blood and reproductive organs
  15. 15. Professor Søren Skov, Department of Veterinary Disease Biology, University of Copenhagen “The over expression seen in cancers such as melanoma, prostate cancer and certain types of leukemia significantly impairs the immune system. If we can find ways to slow down the over-stimulation, we are on the right track. The new results are yet another small step towards better cancer drugs with fewer adverse effects”
  16. 16. The study received support from the Danish Council for Independent Research and the European Marie Curie Initial Training Network. Aside from Skov, other authors include:  Bente Gammelgaard  Lars Ellgaard  Charlotte Gabel-Jensen  Lars Andresen  Stephanie Kehlet  Franziska Uhlenbrock  Michael Hagemann-Jensen
  17. 17. A balanced diet with a variety of vegetables can reduce risk of cancer

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