Molecular Imaging


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Molecular Imaging

  1. 1. GHUCCTS: Translational Technology Resources (TTR) Molecular Imaging Laboratory (MIL, HU) Paul Wang, PhD. Director
  2. 2. Molecular Imaging Laboratory (HU) Provides: <ul><li>High resolution, high sensitivity MRI </li></ul><ul><ul><li>Small animal Bruker 400 MHz (9.4T) 89mm and Varian 200 MHz (4.7T) MRI/MRS systems </li></ul></ul><ul><ul><li>Clinical 3T GE MRI/MRS system </li></ul></ul><ul><ul><li>In vitro and/or In vivo studies </li></ul></ul><ul><li>Experimental design </li></ul><ul><ul><li>Nanoparticle with ligands </li></ul></ul><ul><ul><li>Protein or biochemical pathways </li></ul></ul><ul><li>Multi-photon confocal microcopy </li></ul>
  3. 3. Molecular Imaging Laboratory (HU) Mission Statement <ul><li>The mission of the Howard University Biomedical Imaging Core Facility is to train the new generation young scientists, and foster multidisciplinary research using modern imaging technologies, to study the underline disease processes, and to investigate means to alleviate grave suffering. </li></ul>
  4. 4. Molecular Imaging Laboratory (HU) MRI/MRS Systems In vivo high resolution mouse brain imaging In vivo mouse white/grey matter of spinal cord Varian 4.7T Horizontal bore Bruker 9.4T 89 mm bore MR angiography of mouse brain MR imaging of mouse heart
  5. 5. Molecular Imaging Laboratory (HU) Optical Imaging System Bioluminescence Imaging of Secondary Tumors in Lung, MDA-MB-231-luc cells (BLI able to detect ~ 50 cells in vivo) Emission filter wheel Excitation filter wheel Lens assembly Optical switch Transillumination Fiber bundle Scanning laser Heated sample stage CCD, TE-cooled to -90C 10 excitation and 18 emission filters Tf NIR -Lip NBD -CA Probe for Fluorescense NIR Optical Imaging (a) (b)
  6. 6. Objectives: <ul><li>To provide state-of-the-art instrumentation, technical expertise and essential services for molecular, cellular, and in vivo imaging </li></ul><ul><li>To provide a broader training experience for students and faculty in biomedical imaging through methodology-centered seminars, workshops, mini-courses, and internships </li></ul><ul><li>To foster new multidisciplinary research collaborations using modern imaging technologies. </li></ul>
  7. 7. Areas of Investigations: <ul><li>In vivo MRI and optical imaging of small animals with disease models </li></ul><ul><li>Molecular imaging of disease processes at molecular, subcellular, cellular, and live animal levels </li></ul><ul><li>Development of nanoparticles for diagnostic and therapeutic use </li></ul><ul><li>Novel probe design for targeted drug delivery </li></ul><ul><li>Ex vivo cell imaging by electron microscopy </li></ul>
  8. 8. Molecular Imaging Laboratory (MIL, HU) Contacts: <ul><li>Alexandru Korotcov, PhD </li></ul><ul><li>Manager </li></ul><ul><ul><li>Phone: 202-865-3742 </li></ul></ul><ul><ul><li>Email: [email_address] </li></ul></ul><ul><ul><li> </li></ul></ul>
  9. 9. Support Provided by: <ul><li>Shared Resources are partially supported by the Georgetown Howard University Center for Clinical and Translational Studies (GHUCCTS) 1UL1RR031975-01    In your publications, remember to mention support provided from the GHUCCTS. </li></ul>