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Theories of aging, anti aging


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Theories of aging, anti aging

  1. 1. Dr Ling Sien Ngan Anti Aging, Aesthetic Medical Practitioner
  2. 2. Theories of Ageing <ul><li>Edith Cowan University </li></ul><ul><li>Faculty of Communications, Health & Science </li></ul><ul><li>Post Graduate Study in Andrology & Men’s Health </li></ul>Ee 5 December 2004
  3. 3. <ul><li>Every single day, as we age , more and more people are dying of cancer, or simply of old age </li></ul>
  4. 4. <ul><li>Are you doing something about it? </li></ul>
  5. 5. Lowel Anti Aging + Aesthetic Clinic , SS2 ,PJ
  6. 6. Mission: <ul><li>to enhance QoL </li></ul><ul><li>through comprehensive & integrated </li></ul><ul><li>anti aging & aesthetic healthcare services. </li></ul>
  7. 7. Anti Aging & Aesthetic medical practitioner 1. Anti Aging medicine 2. Men’s health & Andrology 5. Cosmetic surgery 4. Cosmetic Dermatology 3. Holistic complimentary medicine Aesthetic / External Anti aging
  8. 8. 1) Anti aging medicine <ul><li>Balanced diet </li></ul><ul><li>Nutritional supplementations + antioxidants </li></ul><ul><li>Detoxification  ( chelation, colon hydrotherapy, FIR sauna, ozoniser okamizu </li></ul><ul><li>Correct, moderate exercise. </li></ul><ul><li>Weight management </li></ul><ul><li>Syndrome X + Mx of chronic deg dse -CDD </li></ul><ul><li>Osteoporosis </li></ul><ul><li>Bio –identical hormones </li></ul><ul><li>Occupational health  noise , chemical </li></ul><ul><li>Stress Mx: relaxation  meditation , yoga </li></ul><ul><li>Chemoprevention & cancer </li></ul>
  9. 9. vs Wellness Industry Sickness Industry Anti Aging Medicine is Even here can still anti age !
  10. 10. Visible Oxidation damage in action <ul><li>Free radical damage/oxidative stress, same process causing: </li></ul><ul><li>-Iron to rust </li></ul><ul><li>- Cut apple turning brown </li></ul><ul><li>-Underlying initiator of diseases, e.g.: </li></ul>Pigmentation, wrinkle   repairable by cream CAD Multiple sclerosis Cancer Alzheimer’s dementia Stroke Macular degeneration
  11. 11. Theories of Ageing <ul><li>Biologic, epidemiologic, + demographic data – an attempt to identify a cause or process; </li></ul><ul><li>Ageing: an extremely complex, multifactorial process; </li></ul><ul><li>Different theories not mutually exclusive; </li></ul><ul><li>Definition of ageing: open to various interpretations. </li></ul>
  12. 12. Summary of Presentation <ul><li>Life span and Life expectancy. </li></ul><ul><li>Definition of Ageing. </li></ul><ul><li>What causes ageing? </li></ul><ul><li>Clinical approach to ageing. </li></ul>
  13. 13. Theories of Ageing <ul><li>Life span and Life expectancy. </li></ul><ul><li>Definition of Ageing. </li></ul><ul><li>What causes ageing? </li></ul><ul><li>Clinical approach to ageing. </li></ul>
  14. 14. Life Span <ul><li>Maximum life span is the theoretic species specific, longest duration of life, excluding premature unnatural life. </li></ul><ul><ul><li>Jeanne Calment, died July 1997 at age of 122. </li></ul></ul>Lowland gorilla: 47 yrs Horse: 35 yrs American hookworm: 15 yrs Earthworm: 6 yrs
  15. 15. Life Expectancy <ul><li>Life expectancy is the average number of additional years expected for a member of a population, regardless of cause of death. </li></ul>
  16. 16. Theories of Ageing <ul><li>Life span and Life expectancy. </li></ul><ul><li>Definition of Ageing. </li></ul><ul><li>What causes ageing? </li></ul><ul><li>Clinical approach to ageing. </li></ul>
  17. 17. What is Ageing?
  18. 18. Ageing vs Senescence <ul><li>“ Senescence”: </li></ul><ul><ul><li>deteriorative processes that constitute natural causes of death. </li></ul></ul><ul><li>“ Ageing”: </li></ul><ul><ul><li>processes of accruing maturity with the passage of time, including... </li></ul></ul>George Martin. In: The ageing process, 1984
  19. 19. Ageing vs Senescence <ul><li>Positive aspects like: </li></ul><ul><ul><li>- becoming wiser </li></ul></ul><ul><ul><li>- mellow </li></ul></ul><ul><ul><li>- evolution of life style </li></ul></ul>… “ just like wine, improves as it ages but not as it senesces”.
  20. 20. Stages of Lifespan <ul><li>Prenatal life </li></ul><ul><li>Birth </li></ul><ul><li>Postnatal life </li></ul><ul><ul><li>neonatal </li></ul></ul><ul><ul><li>infancy </li></ul></ul><ul><ul><li>childhood </li></ul></ul><ul><ul><ul><li>early </li></ul></ul></ul><ul><ul><ul><li>middle </li></ul></ul></ul><ul><ul><ul><li>late </li></ul></ul></ul><ul><ul><li>adolescence </li></ul></ul><ul><ul><li>adulthood </li></ul></ul><ul><ul><li>senescence </li></ul></ul><ul><li>Death </li></ul><ul><li>fertilisation-10months </li></ul><ul><li>birth thru’week 2 </li></ul><ul><ul><li>3 wks - 1st birthday </li></ul></ul><ul><ul><ul><li>2 - 6 yrs </li></ul></ul></ul><ul><ul><ul><li>7 - 10 yrs </li></ul></ul></ul><ul><ul><ul><li>prepubertal </li></ul></ul></ul><ul><ul><li>6 yrs following puberty </li></ul></ul><ul><ul><li>20 - 65 yrs </li></ul></ul><ul><ul><li>from 65 yrs </li></ul></ul>Ee
  21. 21. What is Ageing? <ul><li>A ubiquitous biologic process, characterised by a progressive, inevitable evolution and maturation until death. </li></ul>Ee Susan A Gaylord, Mark E Williams. In: Geriatrics Review Syllabus, 1990
  22. 22. Theories of Ageing <ul><li>Life span and Life expectancy. </li></ul><ul><li>Definition of Ageing. </li></ul><ul><li>What causes ageing? </li></ul><ul><li>Clinical approach to ageing. </li></ul>Ee
  23. 23. Ageing Process <ul><li>primary ageing </li></ul><ul><li>secondary ageing </li></ul>Ee True primary ageing is an ongoing normal process.
  24. 24. Environmental hazards <ul><li>Ionising radiation? </li></ul><ul><li>Pollutants? </li></ul><ul><li>Chemicals </li></ul><ul><li>Diet? </li></ul><ul><li>Ambient temperature? </li></ul><ul><li>Diseases? </li></ul>Ee
  25. 25. Theories of Ageing <ul><li>“ The scientific study of ageing has been an odd mixture of the accumulation of mountains of dismal evidence that shows that almost anything you can think of goes wrong with age, and proposals of simplistic theories that try to explain ageing in terms of single processes, ranging from defective testicles to shortened telomeres.” </li></ul>Ee Brian Charlesworth, an evolutionary biologist
  26. 26. Theories of Ageing <ul><li>Research in ageing: </li></ul><ul><ul><li>Traditional gerontologist </li></ul></ul><ul><ul><li>Evolutionary biologist </li></ul></ul><ul><li>300 over theories till date! </li></ul>Ee
  27. 27. Theories of Ageing <ul><li>“ Programmed” theories – the biological clocks. </li></ul><ul><li>“ Error” theories – identify environmental insults. </li></ul>Ee
  28. 28. Theories of Ageing <ul><li>Evolutionary </li></ul><ul><li>Molecular </li></ul><ul><li>Cellular </li></ul><ul><li>Systemic </li></ul>Ee Brian T. Weinert and Poala S. Timiras . Theories of Ageing. J Appl Physiol 95: 1706-1716, 2003.
  29. 29. Evolutionary Theories of Ageing <ul><li>Mutation accumulation </li></ul><ul><li>Disposable soma </li></ul><ul><li>Antagonistic pleiotropy </li></ul>Ee
  30. 30. Molecular Theories of Ageing <ul><li>Gene regulation </li></ul><ul><li>Codon restriction </li></ul><ul><li>Error catastrophe </li></ul><ul><li>Somatic mutation </li></ul><ul><li>Dysdifferentiation </li></ul>Ee
  31. 31. Cellular Theories of Ageing <ul><li>Cellular senescence – Telomere theory </li></ul><ul><li>Free radical </li></ul><ul><li>Wear-and-tear </li></ul><ul><li>Apoptosis </li></ul>Ee
  32. 32. System Theories of Ageing <ul><li>Neuroendocrine </li></ul><ul><li>Immunologic </li></ul><ul><li>Rate-of-living </li></ul>Ee
  33. 33. Theories of Ageing <ul><li>Biological theories </li></ul><ul><ul><li>genotropic </li></ul></ul><ul><ul><li>environmental </li></ul></ul><ul><li>Psycho-social theories: </li></ul><ul><ul><li>Disengagement </li></ul></ul><ul><ul><li>Exchange </li></ul></ul><ul><ul><li>Labelling </li></ul></ul><ul><ul><li>Social Stratification </li></ul></ul><ul><ul><li>Political economy </li></ul></ul><ul><ul><li>Continuity </li></ul></ul>Ee
  34. 34. Summary of Presentation <ul><li>Life span and Life expectancy. </li></ul><ul><li>Definition of Ageing. </li></ul><ul><li>What causes ageing? </li></ul><ul><li>Clinical approach to ageing. </li></ul>Ee
  35. 35. Clinical Approach to Ageing Ee True ageing vs disease states Biologic ageing vs chronologic ageing Promoting positive ageing
  36. 36. Positive Ageing: Pre-requisites <ul><li>Ageing is not denied; </li></ul><ul><li>Perceptions and understanding of ageing are not disempowering; </li></ul><ul><li>Differences between people are acknowledged. </li></ul>Ee Mary Davies
  37. 37. Reconceptualisation of Ageing? <ul><li>Ageing exclusively characterised by declines in function & in health? </li></ul><ul><li>Substantial heterogeneity? </li></ul><ul><li>Existence of positive trajectories of ageing? </li></ul><ul><li>Possible avoidance of age-related diseases and disabilities? </li></ul>Ee
  38. 38. Mechanisms of successful ageing <ul><li>Persistence of normal function and plasticity </li></ul><ul><li>Compensatory responses to restore function </li></ul><ul><li>Interventions to replace deficient function </li></ul><ul><li>Changing of health outcome by modifying risk profiles </li></ul><ul><li>Prevention of diseases </li></ul><ul><li>Strengthening of social interactions and support </li></ul>Ee Brian T. Weinert and Poala S. Timiras .
  39. 39. Promote Positive Ageing <ul><li>Acceptance of ageing </li></ul><ul><li>empowerment </li></ul><ul><li>individuality </li></ul><ul><li>physical activity </li></ul><ul><li>social contact/friendship </li></ul><ul><li>developing coping skills </li></ul><ul><li>valuing experience, knowledge etc. </li></ul><ul><li>Denial of ageing </li></ul><ul><li>disempowerment </li></ul><ul><li>being stereotyped </li></ul><ul><li>sedentary lifestyle </li></ul><ul><li>social withdrawal </li></ul><ul><li>psychological stress </li></ul><ul><li>overvaluing paid work </li></ul>Ee Brendan Kennelly Encourage Avoid
  40. 40. Conclusion <ul><li>Ageing process is multifactorial and complex; </li></ul><ul><li>Research is still ongoing to determine the cause(s) or explain the process of ageing; </li></ul><ul><li>None is conclusive; </li></ul><ul><li>One important goal: how does intervention signals the body to delay ageing? </li></ul><ul><li>“ Successful” ageing is possible. </li></ul>Ee
  41. 41. Reading List <ul><li>Brian T. Weinert and Poala S. Timiras . Theories of Ageing. J Appl Physiol 95: 1706-1716, 2003. </li></ul><ul><li>Ageing: A natural history; 1995, RE Ricklefs, CE Finch (WH Freeman & Co). </li></ul><ul><li>Evolutionary biology of aging; 1991, MR Rose (New York: Oxford University Press). </li></ul><ul><li>The Aging Process: therapeutic implications; 1984, RN Butler, AG Bearn (Raven Press). </li></ul><ul><li>Geriatrics Review Syllabus: A core curriculum;1989, JC Beck (American Geriatrics Society). </li></ul><ul><li>Aging as a biological phenomenon: Review in Clinical Gerontology, Vol 1, No. 1, 1991. </li></ul>Ee
  42. 42. How to choose Miss universe supplements ? <ul><li>GMP --Supp manufacturing : poorly regulated </li></ul><ul><li>--Pharm factory adherence > food factory  pharm grade OTC sure better </li></ul><ul><li>Label, full disclosure + address </li></ul><ul><li>--Contain actual amount stated </li></ul>
  43. 43. Choose Ms universe supplement <ul><li>Where products marketed ? </li></ul><ul><li>--Only locally in USA , < stringent </li></ul><ul><li>--To Canada, Australia, Europe > stringent  send on-site inspection regularly </li></ul><ul><li>--3 rd party certification on Quality of manufacturing </li></ul><ul><li>QC testing ( dissolvability ) </li></ul><ul><li>--3/9 prenatal Vit ever dissolved – Uni of marryland </li></ul>
  44. 44. Antioxidant help good cell <ul><li>Side effect of chemo, radio = oxidative stress to normal cell </li></ul><ul><li>Taking ^ dose antioxidant  ^ defense of normal cell while on chemo </li></ul><ul><li> while chemo work at peak, side effect @ minimal---  win-win </li></ul><ul><li>Cancer cell receive double whammy </li></ul><ul><ul><li>Oxidative stress from antioxidant (now pro-oxidant) </li></ul></ul><ul><ul><li>Chemo stress </li></ul></ul>
  45. 45. Vit E Co Q10 B-carotene + vit A Against damage by chemo to lung, liver, kidney, heart, skin Against damage by Adriamycin to heart < side effect of chemo + radio Rx All these antioxidant  protect against damage to DNA of normal cell  From chemo + Radio Rx
  47. 47. If ageing can be halted... Ee The Lost Horizon Would you choose to be in it?
  48. 48. SEEKING A GOOD LIFE STYLE ? <ul><li>Physically and emotionally strong </li></ul><ul><li>Age gracefully </li></ul><ul><li>Feel good factor </li></ul>
  49. 50. Be all that you are Show it off <ul><li>VIBRANT </li></ul><ul><li>RADIANT </li></ul><ul><li>VITALITY </li></ul>Thank you
  50. 51. My contact <ul><li>E mail; [email_address] </li></ul><ul><li>Web; </li></ul><ul><li>You tube; </li></ul><ul><li>Face book; </li></ul>