Marie de' Medici, 1573–1642, queen of France, second wife of King Henry IV and daughter of Francesco de' Medici, grand duke of Tuscany. She was married to Henry in 1600. After his assassination (1610) she became regent for her son Louis XIII. Marie de Médicis, the daughter of the Grand Duke of Tuscany and the Archduchess of Austria, was born in Florence. After the assassination of her husband in 1610, Marie was made regent by the Parlement of Paris.