Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Paget’S Disease Of Bone

27,435 views

Published on

Published in: Health & Medicine
  • Finally, it's been revealed how you can increase your breast size by two cup sizes... All FULLY Naturally. Just see for yourself... ☺☺☺ https://t.cn/A6Li7eze
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • The "END OF GOUT" extensively goes over the nature-based solution that achieves just this. You'll be able to say goodbye to gout, and feel better than ever before, in just 7 days or less!  https://t.cn/A6AZCtO2
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • I would HIGHLY recommend the bulimia recovery program. Shaye and the girls on the site are beyond amazing. Without even meeting anyone, I have felt kindness, love, and incredible support. For that reason alone it is worth it. But the guides, information, meal planning tools, binge tracker, blog, forums, and vidoes are more reasons to join. I truly think that if you struggle with an eating disorder this program will help you overcome it and change your life for the better.  http://scamcb.com/bulimiarec/pdf
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • I purchased your e-book, How to Reverse Diabetes. This is really an amazing life-saving book, it's a blessing beyond words. I've downloaded your program because my dad has been suffering from diabetes for a very long time but now, thanks to your help, his blood sugar level is well within normal range and all his symptoms are gone. I cannot explain in words how much this book has meant to me and my family. I just want to let you know that your program has totally changed my life; you truly are a blessing for humanity. People need to hear your message because it can save many many people’s lives. The world needs more people like you. From the bottom of my heart, thank you thank you thank you! ●●● http://t.cn/A6vI6Tyi
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here

Paget’S Disease Of Bone

  1. 1. Paget’s Disease of Bone (Osteitis Deformans) Hosain Bouallouch Shen Zhou University 10 maart 2006
  2. 2. What is Paget’s disease? <ul><li>It’s a chronic disease of the skeleton </li></ul><ul><li>Normal growth of bone is changed </li></ul><ul><li>*Bone breaks down more quickly </li></ul><ul><li>*Bone can grow larger than before </li></ul>
  3. 3. Bone consists of: Osteoblasts: bone forming cells Osteoclasts: Bone breaking cells Osteocytes: present in the matrix Matrix: collagen, calcium, osteocalcin
  4. 4. Bone remodeling
  5. 5. 2 forms of Paget’s disease <ul><li>Too much bone is formed, so gets larger and breaks easier </li></ul><ul><li>Bone that’s replaced is soft and porous </li></ul>
  6. 6. Bones commonly affected by Paget’s disease
  7. 7. Symptoms <ul><li>Pain in or over a bone </li></ul><ul><li>The affected area may feel extra warm </li></ul><ul><li>The shape of the bone may change </li></ul><ul><li>-the bone in the legs may bend or bow out </li></ul><ul><li>-the bone in the skull may get bigger </li></ul>
  8. 9. Skull of patient with paget’s disease normal skull
  9. 10. <ul><li>Bone breaks more easily </li></ul><ul><li>In late stages hipjoint may damage </li></ul><ul><li>Hearing problems may occur because the bone expands and heart problems may also occur </li></ul>Symptoms
  10. 11. What causes Paget’s disease <ul><li>Unknown; evidence favors an infection of genetically predisposed individuals with a measles virus of the paramyxovirus family </li></ul><ul><li>Studies have demonstrated that abnormal virus-infected osteoclasts generate IL-6, a resorptive cytokine from the bone marrow of patients with Paget’s disease </li></ul>
  11. 12. How common is Paget’s disease <ul><li>The exact number of Paget’s disease is not known </li></ul><ul><li>Men are more likely to be affected than woman </li></ul><ul><li>It usually affects people over the age of 40 years </li></ul><ul><li>It’s estimated to affect 3% of people over the age of 40 </li></ul>
  12. 13. Epidemiology <ul><li>Prevalence </li></ul><ul><li>High: United Kingdom, United States, Australia, New Zealand, Western Europe </li></ul><ul><li>Low: Scandinavia, China, Japan, India </li></ul><ul><li>Family History: positive in as many as 40% of patients </li></ul>
  13. 14. Treatment <ul><li>At this time there is no cure for Paget’s disease. Therefore treatment is designed to control the symptoms and change the rate of bone growth </li></ul>
  14. 15. Treatment <ul><li>Biphosphonates </li></ul><ul><li>heplfull in rebuilding bone </li></ul><ul><li>Inhibits bone resorption and mineralisation by promoting apoptosis of osteoclasts </li></ul><ul><li>for example Didronel, Fosamex and Actonel </li></ul>
  15. 16. Treatment <ul><li>Calcitonin </li></ul><ul><li>Slows bone loss and bone growth </li></ul><ul><li>Gives relieve of bone pain </li></ul><ul><li>Reduces skin temperature over affected bone sites </li></ul><ul><li>For example acetaminophen (Tylenol, Panadol) </li></ul>
  16. 17. Treatment <ul><li>Surgery </li></ul><ul><li>1. fractures: to allow fractures to heal in better position </li></ul><ul><li>2. bone deformity: cutting and realigning of the affected bones </li></ul><ul><li>3. severe degenerative arthritis: joint replacement of the hips, knees </li></ul>
  17. 18. <ul><li>Shall I tell you what true knowledge is? </li></ul><ul><li>If you know </li></ul><ul><li>Knowing that you know </li></ul><ul><li>And if you don’t know </li></ul><ul><li>Knowing that you don’t know </li></ul><ul><li>That is true knowledge </li></ul><ul><li>Confucius Analecten </li></ul>

×