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What Is Lewy Body Dementia


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What Is Lewy Body Dementia

  1. 1. Lewy Body Dementia An Emerging Disease Part 1: What is it? Presented by The Lewy Body Dementia Association, Inc . Increasing Knowledge Sharing Experience Building Hope
  2. 2. Dementia is: A set of symptoms that includes a decline in mental abilities Degenerative: Progressive decline Treatable but not curable Most common Alzheimer's: 50% of all dementias LBD: 15-20% of all dementias <ul><li>Non-progressive: </li></ul><ul><li>Abrupt decline </li></ul><ul><li>Often reversible </li></ul><ul><ul><ul><li>Most common </li></ul></ul></ul><ul><li>Vascular: 15-20% of all dementias </li></ul><ul><li>Many others </li></ul>Others Vascular LBD Alzheimer's
  3. 3. LBD isn’t Alzheimer’s Disease! But it may accompany Alzheimer’s not specifically yes Lethal selectively indiscriminately Kills brain cells fluctuating symptoms general decline Result extracts acetylcholine from nerve cells. weakens, then strangles Action Lewy bodies Placques and Tangles Brain Autopsy LBD AD  
  4. 4. Lewy body in neuron of brain. Red areas: where Lewy bodies are found in brain. Lewy bodies are: Very tiny abnormal protein structures. The kind of symptoms (and the disease) depends on where the bodies reside in the brain
  5. 5. Lewy body dementia (LBD) (often called Dementia with Lewy bodies (DLB) Parkinson’s disease (PD) Parkinson’s disease with dementia (PDD) LBD is a member of the Lewy Body Disease Family
  6. 6. Both Both Both PDD Movement problems Motor Substantia nigra PD Dementia Cognition (memory, thinking) Cerebral cortex LBD Symptoms Function controlled Location in brain Disease name
  7. 7. Why haven’t we heard of LBD before now? <ul><li>1912 Lewy discovered abnormal proteins in motor areas while looking for a cause for Parkinson’s disease. (First discovery of Lewy bodies) </li></ul><ul><li>1984 Kosaka found Lewy bodies in cognitive areas. (First description of Lewy body dementia) </li></ul><ul><li>1996 First formal clinical diagnosis of LBD published. </li></ul><ul><li>(When the neurologists began to recognize of LBD) </li></ul><ul><li>2004 “Dementia with Lewy bodies” received a CPT billing code. </li></ul><ul><li>(When the physicians began to diagnose LBD.) </li></ul><ul><li>2006 PDD-DLB Conference in Washington DC. Agreement that PDD and DLB are essentially the same disease. </li></ul><ul><li>(When the scientists began to equate LBD and PDD) </li></ul>
  8. 8. SPECT (Single-Photon Emission Computed Tomography ) <ul><li>Confirmed diagnosis only possible with brain autopsy </li></ul><ul><li>Clinical diagnosis is via a set of symptoms </li></ul><ul><li>Brain scans can be used to assist diagnosis </li></ul><ul><ul><li>Generally only in research studies in US </li></ul></ul><ul><ul><li>Available/reliable in Europe </li></ul></ul><ul><ul><li>PET (Positron Emission Tomography) </li></ul></ul>How do we know it’s LBD?
  9. 9. LBD Diagnosis Dementia: Must be present for any LBD/PDD diagnosis Core Features Fluctuating cognition Recurrent visual hallucinations Parkinsonism Suggestive Features REM sleep behavior disorder (RBD) Abnormal result on brain scans (PET, SPECT) Diagnosis Probable: Dementia and 2 core, or 1 core and 1 or more suggestive symptoms Possible: Dementia and only 1 core feature, or 1 or more suggestive symptoms
  10. 10. Other symptoms likely to occur with LBD (but not used for diagnosis) Autonomic problems Falls Unresponsiveness Other hallucinations Urinary system problems Delusions Anger, depression, sadness Difficulty swallowing Excessive daytime sleeping Restless Leg Syndrome
  11. 11. <ul><li>The Lewy Body Dementia Association also offers: </li></ul><ul><ul><ul><ul><ul><li>Part 2: Symptoms </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Part 3: Management and Treatment </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Part 4: The LBDA and other resources </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Part 5: Caregiver Care </li></ul></ul></ul></ul></ul>This concludes Part 1 of Lewy Body Dementia, An Emerging Disease
  12. 12. Office Phone: 404-935-6444 Office Email: [email_address] Website: Helpline phone: 800-539-9767 800-LEWY-SOS Helpline email: [email_address] P.O. Box 451429 Atlanta, GA 31145 Contacting the LBDA Thank You for your participation in this learning experience. Increasing Knowledge Sharing Experience Building Hope