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Cell Cycle Control Mechanisms


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Cell Cycle Control Mechanisms

  1. 1. Cell Cycle Controls<br />Biology 3 Kawashima<br />Philippine Science High School<br />SY 2009-2010<br />
  2. 2. Key Terms and Concepts<br />Checkpoints<br />Cyclins<br />Cyclin-dependent kinases<br />
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  4. 4. G1 Checkpoint<br />Also known as “Restriction Point” in mammalian cells<br />Cells that go through G1 usually complete the cell cycle<br />Cells that do not receive the go-signal exit the cell cycle<br />Quiescent non-dividing stage called G0 phase<br />
  5. 5. G1 checkpoint<br />Continue with G1 and proceed to S<br />Exit cycle; switch to nondividing state<br />
  6. 6. G2 Checkpoint<br />MPF or maturation promoting factor drives the cell past the G2 checkpoint<br />MPF is a protein complex composed of cyclins and cyclin-dependent kinases (Cdk)<br />Accumulated cyclin in G2 associate with cyclin-dependent kinases<br />
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  9. 9. M Phase Checkpoint<br />Ensures that chromosomes are properly attached to mitotic spindle (composed of microtubules)<br />Anaphase promoting complex (APC) is inactive until kinetochores have interacted with microtubules<br />Activation of APC indirectly triggers breakdown of cyclins<br />
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  11. 11. External Signals Affect Regulation<br />