Faster Cures For All

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  • KEY CORPORATE AND INSITTUTIONAL PARTICIPANTS IN CITIZEN SCIENCE
  • -cutsdowb
  • Faster Cures For All

    1. 1. Faster Cures For All Geoffrey H. Siwo Co-Founder Fit2Cure Lurie Medical Research Center Northwestern University, Chicago, IL
    2. 2. A century of exponential progress in Health
    3. 3. In 100 years, Life expectancy increased 100%
    4. 4. 93% reduction in child mortality
    5. 5. Time from bench to bedside much shorter
    6. 6. ~200 years since discovery of scurvy-lemon juice association to implementation
    7. 7. Faster time to clinic, last 100 years
    8. 8. But….
    9. 9. 7 million children die before age of 5
    10. 10. Bench to bedside still takes too long
    11. 11. 17 years $1 Billion 90% Failure
    12. 12. >10,000 Monogenic diseases
    13. 13. We don’t even have data for most of these diseases
    14. 14. Cystic Fibrosis
    15. 15. >95% of diseases have no cures
    16. 16. Most medicines don’t work in most people Allen Roses, GSK VP Genetics
    17. 17. Why?
    18. 18. Human Genetic Diversity is Massive
    19. 19. Current system can’t cope
    20. 20. We must empower millions to be part of discovery
    21. 21. Can we really? What if we do? Are we ready for it? Is our policy ready for it?
    22. 22. Can we?
    23. 23. ~3 billion people online by end of this year
    24. 24. What if each computer/ mobile was a lab?
    25. 25. Yes, it’s possible…
    26. 26. … in Africa 2003: Undergraduate in Africa doing computational modeling of HIV on a pay-to-go computer 2003 to 2005: organized Bioinformatics training for fellow students 2010: Students in 2003 group organize First Virtual Bioinformatics Conference in Africa
    27. 27. …in USA • 15 year old Jack Andraka develops pancreatic cancer test: 100 times more sensitive and 28 times cheaper
    28. 28. Even more complex experiments will be possible
    29. 29. Virtual Physiological Human
    30. 30. Virtual Heart- Cardiod project • Near-cellular resolution Real-time simulation of the electrophysiology of the human heart
    31. 31. Virtual Brain
    32. 32. These complex experiments will come to your computer
    33. 33. Everywhere
    34. 34. 628,000 members 2.5 million devices 796,000 years of computing
    35. 35. Something from the Nobel prize in Chemistry 2013
    36. 36. >Half a billion people play computer/ video games for at least 1 hour a day
    37. 37. Why not solve science problems in games?
    38. 38. Fit2Cure A lab and a scientist on every computer
    39. 39. Computers are incredibly fast, accurate and stupid. Human beings are incredibly slow, inaccurate and brilliant. Together they are powerful beyond imagination
    40. 40. With Co-Founders Ian Sander and Victoria Lam
    41. 41. Drug discovery pipeline Identify disease Isolate protein involved in disease (2-5yrs) Foldit Find a drug effective against disease protein (2-5yrs) Fit2Cure Preclinical Testing (1-3yrs) Formulation & Scale-up FILE IND: Human clinical trials (2-10yrs) FILE NDA: FDA approval (2-3yrs)
    42. 42. Game interface
    43. 43. Competition! + Social Impact Compete with friends! In the future: For our top scoring players, we will be donating (real) money to an approved research center or rare & neglected disease institute of your choosing, and in your name.
    44. 44. Emergent patterns in play trace • Expectation-maximization (EM) based mining of player data -user interface design - novel scientific insights
    45. 45. Players can do real science! Time (Mins) HIV-1 Protease
    46. 46. Drug discovery algorithms I.P. of integrating human cognition Drug Binding simulation models Web-based gaming sessions Analytics New Insights New Drugs
    47. 47. Design your medicine in future
    48. 48. Connecting Fit2Cure to Your Genetics: Fit2CureMyDisease • Fit2Cure links personal genome data from the company 23andMe • Fit2Cure can alert you when you are playing with a protein in which you have mutations or allergic drug reactions
    49. 49. Print your own medicine
    50. 50. Or send to robot scientists online to make it and mail it to you
    51. 51. Remote controlled chemistry lab
    52. 52. Hypothesis generating and testing robot scientists
    53. 53. Adam- The Robot Scientist • Adam designed hypotheses, experiments and tested them to discover function of novel yeast genes
    54. 54. Who owns the discoveries?
    55. 55. Who decides which disease should be studied first?
    56. 56. Should players be compensated?
    57. 57. What if players design dangerous chemical from game?
    58. 58. Discoveries are going to happen faster than policy
    59. 59. What are the challenges?
    60. 60. • Fast discovery will outpace our ability to build policy • Policy must anticipate, there will be no time • Central regulation will be extremely difficult since tools will be available to many
    61. 61. What are the opportunities?
    62. 62. • Allow millions to engage in experimentation in what affects them • Democratized and rapid discovery • Realistic simulations of your own health (Personalized medicine) • Preparing the world for an unknown pandemic
    63. 63. Acknowledgements Charles Edison Fund DynamoidApps Fit2Cure Players

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