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Patent landscape report on optogenetics by PatSeer

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This Patent Landscape Report on Optogenetics analyzes research trends with a focus on Targeting Techniques, Sensors, Light Equipments, Actuators and Applications and also highlights the key Applicants involved in this space

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Patent landscape report on optogenetics by PatSeer

  1. 1. OPTOGENETICS PATENT LANDSCAPE REPORT BY PATSEER Disclaimer: The analysis and charts shown in this report have been prepared using PatSeer. This report should not be construed as business advice and the insights are not to be used as the basis for investment or business decisions of any kind without your own research and validation. Gridlogics Technologies Pvt. Ltd disclaims all warranties whether express, implied or statutory, of reliability, accuracy or completeness of results, with regards to the information contained in this report.
  2. 2. © 2019 Gridlogics. All Rights Reserved. Page 2 of 43 OPTOGENETICS - OVERVIEW Optogenetics is a method that uses light to modulate molecular events in a targeted manner in living cells or organisms. It relies on the use of genetically-encoded proteins that change conformation in the presence of light to alter cell behaviour, for example, by changing the membrane voltage potential of excitable cells. It can also be defined as a biological technique that involves the use of light to control cells in living tissue, typically neurons that have been genetically modified to express light-sensitive ion channels. It is a neuromodulation method that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue even within freely moving animals and to precisely measure these manipulation effects in real-time. The key reagents used in optogenetics are light-sensitive proteins. Neuronal control is achieved using optogenetic actuators like channelrhodopsin, halorhodopsin, and archaerhodopsin, while an optical recording of neuronal activities can be made with the help of optogenetic sensors for calcium (GCaMP), vesicular release (synapto-pHluorin), neurotransmitter (GluSnFRs), or membrane voltage (arc lightning, ASAP1), Control (or recording) of activity is restricted to genetically defined neurons and performed in a spatiotemporal-specific manner by light. Optogenetics provides millisecond-scale temporal precision which allows the experimenter to keep pace with fast biological information processing (for example, in probing the causal role of specific action potential patterns in defined neurons). Indeed, to probe the neural code, optogenetics by definition must operate on the millisecond timescale to allow addition or deletion of precise activity patterns within specific cells in the brains of intact animals, including mammals. By comparison, the temporal precision of traditional genetic manipulations (employed to probe the causal role of specific genes within cells, via "loss-of-function" or "gain of function" changes in these genes) is rather slow, from hours or days to months. It is important to also have fast readouts in optogenetics that can keep pace with the optical control. This can be done with electrical recordings ("optrodes") or with reporter proteins that are biosensors, where scientists have fused fluorescent proteins to detector proteins.
  3. 3. © 2019 Gridlogics. All Rights Reserved. Page 3 of 43 PATENT SEARCH STRATEGY Using PatSeer, we searched individual publications and then collapsed them to one member per Invention (Simple Families). Patent families are a group of patent applications in multiple countries which represent the same invention. The publications included in the report are updated as of 14th January 2019. Summary of Search Results:  We started with a set of 3452 search results  We then deduplicated them to unique inventions (Families) and got 1728 Families  We browsed through the resulting set of record to remove any record that was irrelevant to the search topic  We then filtered, analyzed and came across some unwanted terms/Keywords. These records were then removed from the resulting set.  We flagged/rated each individual record using Search Recall™ option present in PatSeer NOTE: All analysis in this report has been done on Simple Family (one member per family) and so the data in the charts should be construed accordingly.
  4. 4. © 2019 Gridlogics. All Rights Reserved. Page 4 of 43 TECHNICAL SEGMENTATION (PATENT CATEGORIZATION) To know the detail of Technical Segmentation image Contact us here:
  5. 5. © 2019 Gridlogics. All Rights Reserved. Page 5 of 43 INNOVATION TRENDS The chart below shows a number of filings and grants for optogenetics. The chart was generated on overall records (3452 Records) and the trend analysis is for the last 15 years. Trend analysis based on the filing of priority application indicates a gradual increase in number of applications being filed post-2013. The maximum number of patent applications (236) taking/having priority were filed during 2016. How we did it? Application and patents with their respective counts were exported as CSV and were converted to a column chart from excel. “Maximum number of patent applications (236) taking/having priority were filed during 2016” OPTOGENETICS: TRENDS
  6. 6. © 2019 Gridlogics. All Rights Reserved. Page 6 of 43 TREND FOR VARIOUS APPLICATION AREAS OF OPTOGENETICS OVER THE LAST 15 YEARS  The chart below represents the growth of different applications of optogenetics in the last 15 years  Research for the cure of neurological diseases like Alzheimer’s, epilepsy, seizure or depression using optogenetics has seen an exponential increase since 2014. How we did it? First records were classified under different application areas. Then these were added as layer on the application year chart. The resulting chart was exported as an image. Note that for analysis the records of 2017 and onwards were excluded as there is a time gap of 18 months for new filings to be published. “Exponential increase in research for the cure of neurological diseases like Alzheimer’s, epilepsy, seizure or depression using optogenetics from 2014” OPTOGENETICS: TRENDS
  7. 7. © 2019 Gridlogics. All Rights Reserved. Page 7 of 43 TREND FOR VARIOUS TARGETING TECHNIQUES OF OPTOGENETICS OVER THE LAST 15 YEARS  The chart below represents the growth of different targeting techniques of optogenetics in the last 15 years  Targeting techniques such as Transgene and Recombinase are more researched and used techniques as companied to Viral Vectors(Retroviruses, Lentiviruses, Adenoviruses) How we did it? First records were classified according to different targeting techniques. Then these were added as layer on the application year chart. The resulting chart was exported as an image. Note that for analysis the records of 2017 and onwards were excluded as there is a time gap of 18 months for new filings to be published. OPTOGENETICS: TRENDS
  8. 8. © 2019 Gridlogics. All Rights Reserved. Page 8 of 43 INVENTIONS ABANDONED AND RENEWED  The chart below gives an account of the inventions abandoned or renewed for optogenetics in the last eight years  Rate of abandonments was high in 2010 but has reduced considerably after that How we did it? First records were added using a query within the Search Query option. Then from the Dashboard for the particular query, the chart for inventions Abandoned or Renewed was downloaded OPTOGENETICS: TRENDS
  9. 9. © 2019 Gridlogics. All Rights Reserved. Page 9 of 43 TECHNOLOGY CYCLE TIME  The chart below gives the measure of how quickly new technologies/inventions are replacing the older once in optogenetics  It is the median age of the patents cited on the front page of a patent document. The measure assumes that the more recent the age of the cited patents, the more quickly one generation of inventions is replacing another  At the current rate it can be seen that the average time technology cycle time is 5.9 years. How we did it? First records were added using a query within the Search Query option. Then from the Dashboard for the particular query, the chart for Technology Cycle Time was downloaded. “Average technology cycle time is 5.9 years.” OPTOGENETICS: TRENDS
  10. 10. © 2019 Gridlogics. All Rights Reserved. Page 10 of 43 KEY AREAS OF RESEARCH FOR OPTOGENETICS RESEARCH ACTIVITY AROUND THE WORLD  Map below represents the geographical filing relating to Optogenetics. The map helps provide an indication of where innovation in this area is originating from.  United States is the leading country in this field with 926 families followed by Japan (119) and China (109). The strength of the coloring represents the proportion of patent applications. How we did it? The map was generated using the Priority country tab under the Quick Stats option. Country Total US 926 JP 119 CN 109 KR 56 DE 54 OPTOGENETICS: CURRENT RESEARCH LANDSCAPE
  11. 11. © 2019 Gridlogics. All Rights Reserved. Page 11 of 43 ACTUATORS ACROSS DIFFERENT TYPES OF APPLICATIONS  The chart below shows the different types of actuators used in various optogenetics applications to trigger the manipulation of neuronal activity with light activation  Channelrhodopsin along with Halorhodopsin are used primarily for neurodegenerative diseases How we did it? First records were classified under different actuators and applications of optogenetics. Then using co-occurrence tool a matrix was generated for the actuators and applications and the resulting matrix was converted to a Stacked Column Chart. “Channelrhodopsin along with Halorhodopsin are used primarily for neurodegenerative diseases” OPTOGENETICS: CURRENT RESEARCH LANDSCAPE
  12. 12. © 2019 Gridlogics. All Rights Reserved. Page 12 of 43 SENSORS ACROSS DIFFERENT TYPES OF APPLICATION  The chart below shows the different types of sensors used in various optogenetics applications  pH sensors are mainly used for cardioversion and neurotransmitter sensors are used to monitor conditions in live tissues for neurodegenerative diseases How we did it? First records were classified under different sensors and applications of optogenetics. Then using co-occurrence tool a matrix was generated for the sensors and applications and the resulting matrix was converted to a Column Chart. “pH sensors are mainly used for cardioversion and neurotransmitter sensors are used to monitor conditions in live tissues for neurodegenerative diseases” OPTOGENETICS: CURRENT RESEARCH LANDSCAPE
  13. 13. © 2019 Gridlogics. All Rights Reserved. Page 13 of 43 TOP CPC CLASSIFICATIONS  The chart below shows the top 10 CPC classifications around which the patents for optogenetics were filed How we did it? Top CPC classifications were loaded form the Quick Stats and converted to a Table Chart. OPTOGENETICS: CURRENT RESEARCH LANDSCAPE
  14. 14. © 2019 Gridlogics. All Rights Reserved. Page 14 of 43 PROMINENT AREAS OF RESEARCH  The chart below shows top technology extracted from the records filed for optogenetics How we did it? Top topics were loaded for the Technology tab within the Quick Stats tab and downloaded as an image. OPTOGENETICS: CURRENT RESEARCH LANDSCAPE
  15. 15. © 2019 Gridlogics. All Rights Reserved. Page 15 of 43 TOP APPLICANTS* PORTFOLIO ANALYSIS (QUANTITATIVE) * Analysis is shown by Ultimate Owners. So the applications of subsidiaries have been merged into their parent organizations
  16. 16. © 2019 Gridlogics. All Rights Reserved. Page 16 of 43 PatSeer 360 correlates patents, business and legal data points in a powerful business-friendly dashboard that makes it easy to identify technology and competitor trends, gaps and opportunities and predict your next move. It includes specialized scoring models which incorporate more than 40 different quality parameters to give you an accurate perspective of the market challengers, leaders, and niche players. For more information on scoring model visit appendix. TOP APPLICANTS - PORTFOLIO SIZE AND QUALITY  The chart represents the top 20 applicants for optogenetics  The 360° Quality score is the weighted average of all the 3 scores, i.e. Citation score (CQ), Legal score (LQ) and Document score (DQ).  It can be seen that there are more number of Universities and research originations in the top applicants with the University of Stanford leading the record count  The pie chart represents the total percentage of the applicant type with all the companies clubbed under Firm. It suggested that even if there more number of universities with the top applicants but the overall filings are dominated by the Firms followed by universities Note: For details about the PatSeer 360 Quality scores please refer the section at end of this report “More number of Universities and research originations in the top applicants with University of Stanford leading the record count” OPTOGENETICS: TOP APPLICANTS* PORTFOLIO ANALYSIS (QUANTITATIVE)
  17. 17. © 2019 Gridlogics. All Rights Reserved. Page 17 of 43 INVENTOR GROUPS OF TOP APPLICANTS FOR OPTOGENETICS  The generated maps below highlight the key inventor groups of top five applicants. In the map below the groups are created using network relationships between the Applicants and the inventors listed on the graph  Key inventors present in the map, for instance, Boyden Edward who appears in between the two clusters of University of Stanford and MIT has collaborative research for the neurodegenerative application for both the universities and hence it is in between the two respective clusters. Similar is the case with Alder Jon Elliot who has filings for University of California and Synomix Inc and Lee Jin Hyung who has filings for University of California and University of Stanford. How we did it? Using the VizMAP tool, patents of top five applicants were loaded on the map. These were then expanded by their respective inventor names. The VizShade option was used to shade the inventors and assignees with potential overlapping patents between them. OPTOGENETICS: TOP APPLICANTS* PORTFOLIO ANALYSIS (QUANTITATIVE)
  18. 18. © 2019 Gridlogics. All Rights Reserved. Page 18 of 43 PORTFOLIO ANALYSIS OF APPLICANTS ACROSS TECHNICAL SEGMENTS APPLICANTS ACROSS DIFFERENT TYPES OF APPLICATIONS  The table below shows research activity of top applicants across different applications of optogenetics  Univ Stanford leads the records count for research around neurodegenerative disease and cardioversion  Acucela has optogenetics application for only retinal diseases How we did it? First records were classified under different application of optogenetics. The applicants were normalized with the help of custom fields. Then using co-occurrence tool a matrix was generated for the applicants and their applications and the resulting matrix was converted to a Column Chart. “Univ Stanford leads the records count for research around neurodegenerative disease and cardioversion” OPTOGENETICS: TOP APPLICANTS* PORTFOLIO ANALYSIS (QUANTITATIVE)
  19. 19. © 2019 Gridlogics. All Rights Reserved. Page 19 of 43 APPLICANTS ACROSS DIFFERENT TARGETING TECHNIQUES  The table below shows research activity of top applicants across different targeting techniques for the use optogenetics  Viral vector is the most popular targeting technique for optogenetics How we did it? First records were classified under different targeting techniques of optogenetics. The applicants were normalized with the help of custom fields. Then using co-occurrence tool a matrix was generated for the applicants and targeting techniques and the resulting matrix was converted to a Bar Chart. OPTOGENETICS: TOP APPLICANTS* PORTFOLIO ANALYSIS (QUANTITATIVE)
  20. 20. © 2019 Gridlogics. All Rights Reserved. Page 20 of 43 APPLICANTS ACROSS DIFFERENT SENSORS  The heat map below shows research activity of top applicants across different sensors used in optogenetics  Synomix leads the research for voltage sensitive and neurotransmitter sensors followed by University of California  pH sensors are widely used for optogenetic applications How we did it? First records were classified under different sensors used for optogenetics. The applicants were normalized with the help of custom fields. Then using co-occurrence tool a matrix was generated for the applicants and sensors and the resulting matrix was converted to a Column Heat Map. “Synomix leads the research for voltage sensitive and neurotransmitter sensors” OPTOGENETICS: TOP APPLICANTS* PORTFOLIO ANALYSIS (QUANTITATIVE)
  21. 21. © 2019 Gridlogics. All Rights Reserved. Page 21 of 43 APPLICANTS ACROSS DIFFERENT LIGHT EQUIPMENTS  The map below shows research activity of Applicants across different light equipments used for optogenetics to expose the cells to light  Univ Stanford has the maximum records for light equipments amongst the universities and Acucela leads the research for the same amongst the Applicants How we did it? First records were classified under different light equipments used for optogenetics. The applicants were normalized with the help of custom fields. Then using co-occurrence tool a matrix was generated for the applicants and light equipments and the resulting matrix was converted to a Tree Map. OPTOGENETICS: TOP APPLICANTS* PORTFOLIO ANALYSIS (QUANTITATIVE)
  22. 22. © 2019 Gridlogics. All Rights Reserved. Page 22 of 43 APPLICANTS ACROSS DIFFERENT ACTUATORS  The heat map below shows research activity of Applicants across different actuators used to control genetically targeted cells. These are primarily light driven actuator proteins  University of Stanford, MIT and Friedrich Miescher Institute lead the research for developing Channelrhodopsin and Halorhodopsin derivatives for the facilitation of neuronal activity which provides insights into light drivable How we did it? First records were classified under different actuators used for optogenetics. The applicants were normalized with the help of custom fields. Then using co-occurrence tool a matrix was generated for the applicants and actuators and the resulting matrix was converted to a Column Chart. “University of Stanford, MIT and Friedrich Miescher Institute lead the research for developing Channelrhodopsin and Halorhodopsin” OPTOGENETICS: TOP APPLICANTS* PORTFOLIO ANALYSIS (QUANTITATIVE)
  23. 23. © 2019 Gridlogics. All Rights Reserved. Page 23 of 43 TECHNOLOGY LANDSCAPE FOR OPTOGENETICS  The landscape map below represents key concepts for different Applicants generated across title, abstract and claims. Themes are collection of prominent topics extracted from the patent data and grouped under relevant parent tags.  Clusters for Taste Receptors and Taste Gene are together as both the clusters are related to each other with high degree of relevance with respect to the text. The nodes were then colored by the assignees. How we did it? The VizMAP tool in PatSeer Pro was used for this analysis. First the clusters were generated on title, abstract and claims using the Advanced Clustering option. Once the clusters were generated these were loaded using the Landscape mode and then the themes were colored by assignees. TECHNOLOGY LANDSCAPE FOR OPTOGENETICS The nodes colored red are for Senomyx which has the maximum number of filings for taste receptor and gene encoding out of the top applicants. Out of its total portfolio 95% relates to the above mentioned technology theme. Some of those family members are US10114009B2, EP3312194A1, CA2827128C, and AU2011236059A1
  24. 24. © 2019 Gridlogics. All Rights Reserved. Page 24 of 43 TOP APPLICANTS PORTFOLIO ANALYSIS (QUALITATIVE)
  25. 25. © 2019 Gridlogics. All Rights Reserved. Page 25 of 43 TOP APPLICANTS THAT ARE COMPANIES (FIRMS) AND THEIR QUALITY ANALYSIS INNOVATION SUMMARY OF TOP APPLICANTS  The chart below shows innovation summary for the top 10 applicants for optogenetics  It compares the 360 quality of the portfolio of the top companies with their invention age.  Bristol Myers has the largest portfolio but the overall invention age for its portfolio is more than 20 years  While companies like Immunolight and Acucela have better 360 quality and their invention age is around 6 and 9 years respectively; which can be considered as being the new challengers in the field of optogenetics How we did it? Once the records were added to the interface click on Companies-By ownership to load the overview. Then click on Innovation Summary to generate the chart. The chart was downloaded as an image after marking the individual companies on the chart “Bristol Myers has the largest portfolio but the overall invention age for its portfolio is more than 20 years” OPTOGENETICS: TOP APPLICANTS PORTFOLIO ANALYSIS (QUALTITATIVE) The 360° score is the weighted average of all the 3 scores, i.e. Citation score (CQ), Legal score (LQ) and Document score (DQ). The patent with a higher 360° score indicates the impact to the market, technological strength, defensiveness, aggressiveness of the company. Invention age is the number of years since filing of the invention Note: For details about the PatSeer 360 Quality scores please refer the section at end of this report
  26. 26. © 2019 Gridlogics. All Rights Reserved. Page 26 of 43 TOP APPLICANTS WITH CITATION AND LEGAL QUALITY  The chart below shows top applicants with the citation and legal quality of their portfolio  Applicants like Canon and Cardiome have low citation and legal quality which indicates that their offensive and defensive potential against any lawsuit is low  Senomyx and Euro Celtique have high citation as well as legal Quality so these companies are high on their defensive and offensive quality How we did it? Once the records were added to the interface click on Companies-By ownership to load the overview. Then click on Assert Vs Defend to generate the chart. The chart was then downloaded as an image after marking the individual companies on the chart OPTOGENETICS: TOP APPLICANTS PORTFOLIO ANALYSIS (QUALTITATIVE) Citation quality indicate the impact of the record in the technology. The probability of a record with a higher citation score being used in company’s offensive strategy or for monetization is higher Legal quality indicate the aggressiveness and investments of the company to protect the invention and also a measure of its perceived threat to the competition Note: For details about the PatSeer 360 Quality scores please refer the section at end of this report
  27. 27. © 2019 Gridlogics. All Rights Reserved. Page 27 of 43 TOP APPLICANTS THAT ARE UNIVERSITIES (UNIV) AND THEIR QUALITY ANALYSIS INNOVATION SUMMARY OF TOP UNIVERSITIES  The chart below shows innovation summary for the top 10 Universities for optogenetics  Its compares the 360 quality of the portfolio of the top Universities with their invention age.  University of Stanford has the largest portfolio and 360 quality, which indicates that it can challenge other innovators in this field How we did it? Once the records were added to the interface click on Companies-By ownership to load the overview. Filter the top universities for the filters available by clicking on Company Type option within the filters. Then click on Innovation Summary to generate the chart. The chart was downloaded as an image after marking the individual companies on the chart Note: For details about the PatSeer 360 Quality scores please refer the section at end of this report “University Of Stanford has the largest portfolio and 360 quality, which indicates that it can challenge other innovators in this field” OPTOGENETICS: TOP UNIVERSITIES QUALITY ANALYSIS
  28. 28. © 2019 Gridlogics. All Rights Reserved. Page 28 of 43 TOP UNIVERSITIES AND THEIR RESEARCH CALIBER  The chart below shows top 10 universities with respect to their Originality and Generality scores  University of Stanford has the largest portfolio size amongst the top universities but still it is behind University TUFTS in terms of the overall radical idea of its invention and its applications  MIT also has a large portfolio but their inventions cannot be considered as radical or unique owing to its Originality score thereby earning limited economic potential How we did it? Once the records were added to the interface click on Companies-By ownership to load the overview. Filter the top universities for the filters available by clicking on Company Type option within the filters. Then click on the Citation tab and then on R&D Caliber to generate the chart. The chart was downloaded as an image after marking the individual companies on the chart OPTOGENETICS: TOP UNIVERSITIES QUALITY ANALYSIS Originality shows a measure of how radical an invention is Generality shows a measure of how generic (applicable to multiple areas) an invention is Note: For details about the PatSeer 360 Quality scores please refer the section at end of this report
  29. 29. © 2019 Gridlogics. All Rights Reserved. Page 29 of 43 TOP UNIVERSITIES RANKED BY ORIGINALITY  The chart below represents the top universities ranked on the basis of their radical ideas  It can be seen that University Florida has a small portfolio but its inventions are radical and at the same time have high generality value which indicates that the inventions will have multiple applications  University TUFTS has the Generality amongst the top universities innovating in optogenetics How we did it? Once the records were added to the interface click on Companies-By ownership to load the overview. Filter the top universities for the filters available by clicking on Company Type option within the filters. The resulting table was downloaded as an image. “University Florida has a small portfolio but its inventions are radical and at the same time have high generality value which indicates that the inventions will have multiple applications” OPTOGENETICS: TOP UNIVERSITIES QUALITY ANALYSIS
  30. 30. © 2019 Gridlogics. All Rights Reserved. Page 30 of 43 NEW ENTRANTS PORTFOLIO ANALYSIS (QUANTITATIVE)
  31. 31. © 2019 Gridlogics. All Rights Reserved. Page 31 of 43 NEW ENTRANTS IN THE LAST 5 YEARS The New Entrants in this section are the new entrants in the field of optogenetics in the last five years. 1. CIRCUIT THERAPEUTICS INC 2. CARIS SCIENCE INC 3. GALVANI BIOELECTRONICS 4. ALDEYRA THERAPEUTICS INC 5. FUNCTIONAL NEURMODULATION INC 6. AXION BIOSYSTEM INC 7. DR NONA INTERNATIONAL LTD 8. INSCOPIX INC 9. KYUNGPOOK NAT UNIV IND ACAD INNOVATION TIMELINE FOR THE NEW ENTRANTS  The chart below shows the innovation timeline representing patenting activity for the new entrants for optogenetics in the last 5 years  Kyungppok National University was one of the early fliers and had its first filing in the year 2013, but their filings have dropped in the last five years  Circuit Therapeutics leads the list of new entrants How we did it? Once the patents were added to PatSeer Projects, key assignees (identified by online research) were filtered and a filter set was created for the same. Then from the Quick Stats Tab innovation timeline was generated and converted to a bubble chart. NEW ENTRANTS PORTFOLIO ANALYSIS (QUANTITATIVE)
  32. 32. © 2019 Gridlogics. All Rights Reserved. Page 32 of 43 INNOVATIONS ACROSS DIFFERENT TARGETING TECHNIQUES FOR THE NEW ENTRANTS IN OPTOGENETICS  The chart below shows number of patents held by new entrants across various Targeting techniques of optogenetics How we did it? First new entrants in optogenetics were identified by online review and these were analyzed with respect to the targeting techniques of optogenetics. The resulting matrix was the converted to a Tree Map and the chart was exported as an image. NEW ENTRANTS PORTFOLIO ANALYSIS (QUANTITATIVE)
  33. 33. © 2019 Gridlogics. All Rights Reserved. Page 33 of 43 NEW ENTRANTS ACROSS SENSORS  The chart below shows activity of new entrants across different sensors used for optogenetics  Functional Neuromodulation Inc leads the records count for neurotransmitter and pH sensors How we did it? Once the patents were added to PatSeer Projects, key assignees were filtered and a filter set was created for the same. Co-occurrence analyzer was used to generate a matrix for new Applicants and sensors. The resulted matrix was then converted to a Bar Chart and exported as image. “Functional Neuromodulation Inc leads the records count for neurotransmitter and pH sensors” OPTOGENETICS: COMPANY SPOTLIGHT WRT NEW ENTRANTS
  34. 34. © 2019 Gridlogics. All Rights Reserved. Page 34 of 43 NEW ENTRANTS ACROSS ACTUATORS  The chart below shows activity of new entrants across actuators used for optogenetics  Circuit Therapeutics Inc leads the records count for all the actuators used in optogenetics How we did it? Once the patents were added to PatSeer Projects, new assignees were filtered and a filter set was created for the same. Co-occurrence analyzer was used to generate a matrix for key Applicants and actuators. The resulted matrix was then converted to a Column Chart and exported as an image. OPTOGENETICS: COMPANY SPOTLIGHT WRT NEW ENTRANTS
  35. 35. © 2019 Gridlogics. All Rights Reserved. Page 35 of 43 NEW ENTRANTS ACROSS APPLICATIONS  The chart below shows activity of new entrants across different applications of optogenetics  Circuit Therapeutic Inc and Functional Neuromodulation Inc have research interest for the cures of neurodegenerative diseases  Caris Science Inc leads the research for cardioversion and retinal diseases How we did it? Once the patents were added to PatSeer Projects, new entrants were filtered and a filter set was created for the same. Co-occurrence analyzer was used to generate a matrix for key Applicants and application. The resulted matrix was then converted to a Column Chart and exported as an image. “Caris Science Inc leads the research for cardioversion and retinal diseases” OPTOGENETICS: COMPANY SPOTLIGHT WRT NEW ENTRANTS
  36. 36. © 2019 Gridlogics. All Rights Reserved. Page 36 of 43 NEW ENTRANTS SUMMARY REPORT  The chart below shows summary report for new entrants with respect to their technology sub domain and industry Parent Assignee Total Current Assignee Tech Sub Domain Industry CIRCUIT THERAPEUTICS INC 9(0.52)% CIRCUIT THERAPEUTICS INC : 9 BOARD OF TRUSTEES OF LELAND STANFORD : 1 STAHLER KATHRYN J : 1 UNIV LELAND STANFORD JUNIOR : 1 MEDICAL TECHNOLOGY : 9 PHARMACEUTICALS : 6 BIOTECHNOLOGY : 1 IRRADIATION, ELECTROMEDICAL AND ELECTROTHERAPEUTIC EQUIPMENT: 9 BASIC PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL PREP. : 6 MEDICAL AND DENTAL INSTRUMENTS AND SUPPLIES : 4 CARIS SCIENCE INC 6(0.35)% CARIS SCIENCE INC : 6 BIOTECHNOLOGY : 5 ANALYSIS OF BIOLOGICAL MATERIALS : 4 ORGANIC FINE CHEMISTRY : 2 PHARMACEUTICALS : 1 BASIC PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL PREP. : 6 MEASURING, TESTING AND NAVIGATION INSTRUMENTS; WATCHES AND CLOCKS : 4 OTHER CHEMICAL PRODUCTS : 1 ALDEYRA THERAPEUTICS INC 4(0.23)% ALDEYRA THERAPEUTICS INC : 4 ORGANIC FINE CHEMISTRY : 3 PHARMACEUTICALS : 3 BASIC PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL PREP. : 4 AXION BIOSYSTEM INC 3(0.17)% AXION BIOSYSTEM INC : 3 ANALYSIS OF BIOLOGICAL MATERIALS : 3 MEASUREMENT : 2 CHEMICAL ENGINEERING : 1 DIGITAL COMMUNICATION : 1 MEDICAL TECHNOLOGY : 1 MEASURING, TESTING AND NAVIGATION INSTRUMENTS; WATCHES AND CLOCKS : 3 MEDICAL AND DENTAL INSTRUMENTS AND SUPPLIES : 2 COMMUNICATION EQUIPMENT : 1 INSCOPIX INC 3(0.17)% INSCOPIX INC : 3 MEASUREMENT : 3 OPTICS : 3 MEDICAL TECHNOLOGY : 2 AUDIO-VISUAL TECHNOLOGY : 1 COMPUTER TECHNOLOGY : 1 MEASURING, TESTING AND NAVIGATION INSTRUMENTS; WATCHES AND CLOCKS : 3 OPTICAL INSTRUMENTS AND PHOTOGRAPHIC EQUIPMENT : 3 MEDICAL AND DENTAL INSTRUMENTS AND SUPPLIES : 2 COMMUNICATION EQUIPMENT : 1 COMPUTERS AND PERIPHERAL EQUIPMENT : 1 KYUNGPOOK NAT UNIV IND ACAD 3(0.17)% KYUNGPOOK NAT UNIV IND ACAD : 3 ANALYSIS OF BIOLOGICAL MATERIALS : 3 MEASURING, TESTING AND NAVIGATION INSTRUMENTS; WATCHES AND CLOCKS : 3 DR NONA INTERNATIONAL LTD 2(0.12)% DR NONA INTERNATIONAL LTD : 2 PHARMACEUTICALS : 2 BASIC PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL PREP. : 2 OPTOGENETICS: COMPANY SPOTLIGHT WRT NEW ENTRANTS
  37. 37. © 2019 Gridlogics. All Rights Reserved. Page 37 of 43 BOARD OF TRUSTEES OF LELAND STANFORD 1(0.06)% BOARD OF TRUSTEES OF LELAND STANFORD : 1 CIRCUIT THERAPEUTICS INC : 1 UNIV LELAND STANFORD JUNIOR : 1 MEDICAL TECHNOLOGY : 1 PHARMACEUTICALS : 1 BASIC PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL PREP. : 1 IRRADIATION, ELECTROMEDICAL AND ELECTROTHERAPEUTIC EQUIPMENT : 1 FUNCTIONAL NEURMODULATION INC 2(0.06)% FUNCTIONAL NEURMODULATION INC : 2 FUNCTIONAL NEUROMODULATION INC : 2 MEDICAL TECHNOLOGY : 2 IRRADIATION, ELECTROMEDICAL AND ELECTROTHERAPEUTIC EQUIPMENT :2 MEDICAL AND DENTAL INSTRUMENTS AND SUPPLIES : 2 GALVANI BIOELECTRONICS LTD 1(0.06)% GALVANI BIOELECTRONICS LTD : 1 MEDICAL TECHNOLOGY : 1 IRRADIATION, ELECTROMEDICAL AND ELECTROTHERAPEUTIC EQUIPMENT : 1 MEDICAL AND DENTAL INSTRUMENTS AND SUPPLIES : 1 STAHLER KATHRYN J 1(0.06)% CIRCUIT THERAPEUTICS INC : 1 STAHLER KATHRYN J : 1 MEDICAL TECHNOLOGY : 1 PHARMACEUTICALS : 1 BASIC PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL PREP. : 1 IRRADIATION, ELECTROMEDICAL AND ELECTROTHERAPEUTIC EQUIPMENT : 1 MEDICAL AND DENTAL INSTRUMENTS AND SUPPLIES : 1 UNIV LELAND STANFORD JUNIOR 1(0.06)% BOARD OF TRUSTEES OF LELAND STANFORD : 1 CIRCUIT THERAPEUTICS INC : 1 UNIV LELAND STANFORD JUNIOR : 1 MEDICAL TECHNOLOGY : 1 PHARMACEUTICALS : 1 BASIC PHARMACEUTICAL PRODUCTS AND PHARMACEUTICAL PREP. : 1 IRRADIATION, ELECTROMEDICAL AND ELECTROTHERAPEUTIC EQUIPMENT : 1 How we did it? First new entrants in the last 5 years in optogenetics were identified by online review and these were filtered from the Apply Filter option present. Once this was done then Summary Report option was selected. Then under “generate report for” option Applicants (under custom fields) option were selected. Parameters required for analysis were selected from the option “Patent Fields” and the resulting chart was generated and then exported as an excel file.
  38. 38. © 2019 Gridlogics. All Rights Reserved. Page 38 of 43 NEW ENTRANTS PORTFOLIO ANALYSIS (QUALITATIVE)
  39. 39. © 2019 Gridlogics. All Rights Reserved. Page 39 of 43 INNOVATION SUMMARY OF NEW ENTRANTS IN THE LAST 5 YEARS  The chart below shows the new entrants and their innovation summary  Axion Biosystem has its originality at 0.8; which means that even if its portfolio size or the total inventions are less but the inventions are radical or original How we did it? New entrants were identified from PatSeer 360 and online research. Once the records for those were added to the interface click on Companies-By ownership to load the overview. Then click on Innovation Summary to generate the chart. The chart was downloaded as an image after marking the individual companies on the chart “Axion Biosystem has its originality at 0.8; which means that even if its portfolio size or the total inventions are less but the inventions are radical or original” OPTOGENETICS: NEW ENTRANTS PORTFOLIO ANALYSIS (QUALITATIVE)
  40. 40. © 2019 Gridlogics. All Rights Reserved. Page 40 of 43 SUMMARY This report analyzes research trends of optogenetics with a focus on Targeting Techniques, Sensors, Light Equipments, Actuators and Applications and also highlights the key Applicants involved in this space. The field of optogenetics has furthered the fundamental scientific understanding of how specific cell types contribute to the function of biological tissues such as neural circuits in vivo (see references from the scientific literature below). Moreover, on the clinical side, optogenetics-driven research has led to insights into Parkinson's disease and other neurological and psychiatric disorders. Indeed, optogenetics papers in 2009 have also provided insight into neural codes relevant to autism, Schizophrenia, drug abuse, anxiety, and depression. The use of the optogenetic tools is mostly seen in the American and European region. The awareness about the products of optogenetic is increasing in the other region as compared to the developed regions. To get this project shared with you via PatSeer’s Patent Dashlet and to obtain access of dataset behind this report, Contact us here:
  41. 41. © 2019 Gridlogics. All Rights Reserved. Page 41 of 43 PATSEER 360° QUALITY SCORES The Legal Quality Score factors the following parameters:  Legal Status: Alive or Dead - Legal Quality Score is 0 if record is Dead  Alive Status: Granted / Pending - Positive Correlation  Invention Coverage: Distinct Countries the invention is filed in - Positive Correlation  Countries where the invention is filed - Higher GDP countries have higher weightage  Count of family members - Positive Correlation  Remaining Life of Invention - Positive Correlation  Litigations - Positive Correlation PATSEER 360° QUALITY SCORES PatSeer 360° includes a 360° Quality Score that comprehensively represents the overall quality of the patent family. It covers a total of 30+ different parameters associated with the patent family. The 360° Score is calculated as a weighted average of three scores that cover three independent viewpoints to the patent family – namely Citation, Legal and Document (Intrinsic) Qualities. Each Score is evaluated for an invention (= patent simple family) and is a value between 0 and 100. The scores calculated are absolute values and are not relative to the analyzed dataset. The Scoring Model comprises: 1. Citation Quality Score (CQ) 2. Legal Quality Score (LQ) 3. Document/Intrinsic Quality Score (DQ) 4. 360° Quality Score Patents ranking higher on score tend to be of better quality and the probability of higher quality patents being used for assertion, licensing or litigation, in a company's IP strategy is higher. CITATION QUALITY SCORE (CQ) CQ Scores indicate the impact of the record in the technology. The probability of a record with a higher citation score being used in company’s offensive strategy or for monetization is higher. Citation Quality Score considers all the citation related parameters to quantify the quality of a document. These are:  No. of Forward citations (Family) - Positive Correlation  Last 5 years forward citation count - Positive Correlation  X, Y, I category forward citations - Positive Correlation  Generality - Positive Correlation  Originality - Positive Correlation  Number of References - Positive Correlation  Number of Backward Citations - Positive Correlation  Examiner vs Inventor Citations – Negative Correlation For each patent family its individual values are ranked statistically against the reference technology domain it falls into and the final Quality Score is the Weighted Average of the ranking of the family across the parameters. LEGAL QUALITY SCORE (LQ) The legal score indicate the aggressiveness and investments of the company to protect the invention and also a measure of its perceived threat to the competition. A higher LQ portrays that the invention is well covered across different geographies and reflects the patenting strategies of innovators and peculiarities in the different patenting systems providing insightful indicator of the value of patented innovations.
  42. 42. © 2019 Gridlogics. All Rights Reserved. Page 42 of 43  Oppositions - Positive Correlation  Re-examinations - Positive Correlation  NPE owned? - Positive Correlation  Ongoing Collateral – Negative Correlation DOCUMENT/INTRINSIC QUALITY SCORE (DQ) Document Quality Score is the technical quality indicator of the patent. A likelihood of a patent with higher DQ indicates innovation quotient and the capabilities of the company to innovate. Some of the parameters taken in consideration are:  Science linkage - Positive Correlation  Co applicants - Positive Correlation  Technological Scope: Unique 4 digit IPC/CPC Classes - Positive Correlation  Number of total and independent claims - Positive Correlation  First Claim word count – Negative Correlation  Count of Inventors - Positive Correlation  SEP - Positive Correlation  Orange Book - Positive Correlation  Time to grant - Positive Correlation DQ scores indicate the corporate technical strength and the R&D quality of the company. 360° QUALITY SCORE The 360° score is the weighted average of all the 3 scores, i.e. Citation score (CQ), Legal score (LQ) and Document score (DQ). The patent with a higher 360° score indicates the impact to the market, technological strength, defensiveness, aggressiveness of the company. The probability of company using the patents with good 360° scored for their products, economic progress and their core strategies is higher.
  43. 43. © 2019 Gridlogics. All Rights Reserved. Page 43 of 43 ABOUT PATSEER PatSeer is a web based global patent database and research platform with integrated analytics, project workflow, and collaboration capabilities. Built using latest web technologies, PatSeer hides the complexities of searching across worldwide data with its intuitive interface. With updates and features added almost monthly / bimonthly PatSeer is serving the varying operational and strategic needs of IP community. ABOUT PATSEER 360 PatSeer 360 correlates patents, business and legal data points in a powerful business-friendly dashboard that makes it easy to identify technology and competitor trends, gaps and opportunities and predict your next move. It provides unique insights into technologies, companies and the quality and quantity of patent portfolios they hold, with a pioneering dashboard, PatSeer 360 opens a whole new realm of possibilities for IP decision making. For more information visit: www.patseer.com/360-edition/ ABOUT PATSEER PRO PatSeer Pro is a powerful and flexible web-based Patent Search, Analytics and Landscaping Platform. It includes a comprehensive set of analytical tools needed for precise technology landscaping and competitive intelligence projects such as Assignee cleanup tools, Co- occurrence Matrices, configurable Chart Dashboards, multi-generation Citation Analysis, Text Clustering and VizMAP – a spatial exploration and contour mapping visualization engine. For more information visit: www.patseer.com/pro-edition/ © 2019 Gridlogics. All Rights Reserved. PatSeer™ is a trademark of Gridlogics Technologies Pvt. Ltd. Feedbacks and Comments on this report can be sent to feedback_tr@patentinsightpro.com PATSEER EDITIONS

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