<ul><li>Provenge
PAP – GM-CSF
Take dendritic cells out of patient and ship to company
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Review 4.30.2010

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Review 4.30.2010

  1. 1. <ul><li>Provenge
  2. 2. PAP – GM-CSF
  3. 3. Take dendritic cells out of patient and ship to company
  4. 4. PAP – antigen w/ epitopes on prostate cancer cell
  5. 5. GM-CSF – growth factor activator of dediritic cells
  6. 6. Inject person with 3 injections
  7. 7. Autophagy
  8. 8. Main role
  9. 9. ER buds and forms a vacuole around an organelle
  10. 10. Forms an autosome/autophagosome
  11. 11. Fuses with lysosome
  12. 12. Making an autophagosolysosome
  13. 13. Digestive enzymes break apart
  14. 14. Bits can be reused by cell or spit out
  15. 15. Apoptosis
  16. 16. Extrinisic
  17. 17. Fas/FasL
  18. 18. FADD
  19. 19. Procaspase 8 activated
  20. 20. Cleaves and activates procaspase 3
  21. 21. Leads to apoptosis
  22. 22. Perforin/granzyme pathways)
  23. 23. Intrinsic Pathway
  24. 24. Cytochrome c release
  25. 25. Controlled by downregulation of BCL2 or upregulation of proteins like Bax
  26. 26. Apaf-1 linkage
  27. 27. Makes apotosome
  28. 28. Clveaves porcaspase 9 > making caspase 9
  29. 29. Leads to activation of caspase 3
  30. 30. Depends on protein synthesis
  31. 31. Ras pathway
  32. 32. Activators are RTKs
  33. 33. Cytoplasmci regions autophosphorylate one another and put Pi on cytoplasmic side of receptor
  34. 34. Recruits SH2 adapter and recruits a GEF for Ras
  35. 35. GEF and Ras interact
  36. 36. GDP is stripped from Ras and GTP is in higher concentrations, binding to Ras and activating it
  37. 37. Activated Ras:
  38. 38. Small g proteins (GTP binding proteins down stream of RTK can function as protein kinases when active)
  39. 39. Serine threonine kinase function when bound to GTP
  40. 40. Raf/Map KKK
  41. 41. Pi Map KK
  42. 42. Pi Map K (Erk)
  43. 43. Drives gene transcription
  44. 44. Drives production of cyclins
  45. 45. Synthesisze outher S phase proteins
  46. 46. Gene transcription factors that can be turned on
  47. 47. Ras can drive cell survival, differentiation
  48. 48. Ras can regulate cytoskeletal dynamics, influencing shape and mobility of cells
  49. 49. Small g proteins regulate cytoskeleton and ras can determine how these function as well
  50. 50. MT and actin binding poritein
  51. 51. Rac Cdc42
  52. 52. Rho
  53. 53. G1/S Cdk Cyclins
  54. 54. PKB
  55. 55. Pi Bad
  56. 56. Bad releases Bcl2
  57. 57. Stabilizes mitochondrial membrane
  58. 58. Reduces apoptosis
  59. 59. Tumor suppressor
  60. 60. Regulate mitosis in the cell
  61. 61. Mutator genes
  62. 62. Genes that when activated will increase rate of mutation in cell
  63. 63. Can upregulate gene transcription
  64. 64. Interphase
  65. 65. Prepares for prophase
  66. 66. G1
  67. 67. G1 Cdk Cyclins
  68. 68. G1/S Cdk cyclins
  69. 69. Looks at DNA if replicated
  70. 70. S phase protein generated to go to S phase
  71. 71. G0
  72. 72. Repair or apoptosis
  73. 73. S Phase
  74. 74. S Cdk cyclin
  75. 75. DNA replicated
  76. 76. G2
  77. 77. M Cdk cyclin
  78. 78. Checks for cell size
  79. 79. MCdk
  80. 80. Checks to make sure enough cyclin (cyclin B) that can be connected to M Cdk to got to mitosis
  81. 81. Mitosis
  82. 82. M/Anapahase transition
  83. 83. Lined up chromosomes at center
  84. 84. If yes, pulls apart
  85. 85. APC and tension allow for the chromosomes to be pulled apart by cleaving cohesion and degrades cyclin B on Mcdk

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