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Diabetic Presentation Corrected

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Diabetic Presentation Corrected

  1. 1. EVALUATION OF THERAPEUTIC RESPONSE OF METFORMIN HCl AND ITS RATIONALE COMBINATIONS ON GLYCEMIC VALUE IN DIABETICS C SUJANI B UMA MAHESH B SUNIL GAVASKAR D SIVA SANKAR K V HIMA BINDU K V GOPINATH & B PUSHPA KUMARI DEPARTMENT OF PHARMACOLOGY SRI PADMAVATHI SCHOOL OF PHARMACY TIRUPATI - 517 503 (A.P.) INDIA
  2. 2. Aim <ul><li>To evaluate the therapeutic response of Metformin HCl & it’s rationale combinations </li></ul>
  3. 3. Objectives      <ul><li>To assess the therapeutic response </li></ul><ul><li>To appropriately counsel patients & evaluate the outcome of the same </li></ul><ul><li>Adverse drug reactions </li></ul><ul><li>Diabetic complications </li></ul><ul><li>BMI & Demographic data </li></ul>
  4. 4. Plan of Work Design of Study Retrospective and prospective Study Site T.T.D Central hospital, SVIMS Study Period October, 06 to March, 2007
  5. 5. Inclusive Criteria <ul><li>Type 1 diabetic and Type 2 diabetics </li></ul><ul><li>Age group 12 to 60 and above </li></ul><ul><li>Glucometer tests </li></ul><ul><li>Sign written informed consent </li></ul>
  6. 6. Exclusive Criteria <ul><li>Patients with chronic diseases </li></ul><ul><li>Less than 90%compliant in drug usage </li></ul><ul><li>Voluntary withdrawal </li></ul><ul><li>Pregnant women and children </li></ul>
  7. 7. Plan of Work <ul><li>Phase I </li></ul><ul><li>Provide basic diabetic facts </li></ul><ul><li>Written and verbal instructions </li></ul><ul><li>Advise on use of ER </li></ul><ul><li>Medications </li></ul>
  8. 8. Plan of Work <ul><li>Phase II </li></ul><ul><li>Patients having clinical symptoms of diabetic </li></ul><ul><li>Diabetic diagnosis on basis of glucometer test </li></ul><ul><li>Prescribing diabetic drugs </li></ul><ul><li>Signing consent form by the patient </li></ul><ul><li>Designing of a standard data collection </li></ul><ul><li>Patient Counseling </li></ul>
  9. 9. Plan of Work <ul><li>Phase III </li></ul><ul><li>Establish therapeutic goals </li></ul><ul><li>Provide instructions for monitoring and reporting </li></ul><ul><li>Practice use of glucometer test </li></ul>
  10. 10. Plan of Work <ul><li>Follow-up </li></ul><ul><ul><li>See patients every 30 days interval </li></ul></ul><ul><ul><li>Assess attainment of goals </li></ul></ul><ul><ul><li>Make necessary adjustments to treatment </li></ul></ul><ul><ul><li>Updated written Diabetic (self) Action Plan </li></ul></ul><ul><ul><li>Check patient’s Glucometer test </li></ul></ul><ul><ul><li>Assessment of outcome variables by Standard statistical analysis </li></ul></ul>
  11. 11. Data on diseases
  12. 12. Demographic data based on sex (n=320)
  13. 13. Demographic data based on age (n=320)
  14. 14. Demographic data based on education (n=320)
  15. 15. Demographic data based on Occupation
  16. 16. Demographic data based on Smoking (n=320)
  17. 17. Demographic data based on Alcohol social habit (n=320)
  18. 18. Demographic data based on Mean + SD (n=206)
  19. 19. Causes of diabetes (n=320)
  20. 20. Risk factor - BMI
  21. 21. Demographic data based on treatment profile (n=210)
  22. 22. Effect of anti-diabetic drug(s) 0n glycemic value (%change)
  23. 23. Percentage change in glycemic value of Metformin HCl
  24. 24. Percentage change in glycemic value of Metformin + Glibenclamide treatment
  25. 25. Percentage change in glycemic value of Metformin + Glipizide treatment
  26. 26. Percentage change in glycemic value of Met + Pioz + Acarbose treatment
  27. 27. Therapeutic response of anti-diabetic drug(s) on glycemic value
  28. 28. Adverse Drug Reactions of Anti-Diabetic Drugs (n=320)
  29. 29. Data on diabetic complications
  30. 30. Conclusion <ul><li>Glimepride, pioglitazone and metformin or Acarbose, pioglitazone and metformin have a complementary mechanisms of action combination therapy with these agents result in improved glycemic control and improved tolerability at lower doses of individual agents. </li></ul><ul><li>Diabetes is more common in overweight or obese persons. </li></ul><ul><li>The impact of patient counseling on management of Diabetes was studied and it is very significant. </li></ul>
  31. 31. Conclusion <ul><li>Improves confidence, and patient compliance </li></ul><ul><li>Cuts cost of therapy </li></ul><ul><li>Minimize the usage of medication per day </li></ul><ul><li>Reduces side effects, and diabetic complications </li></ul>
  32. 32. Sincere Thanks <ul><li>Faculty members, SPSP </li></ul><ul><li>The Principal, SPSP </li></ul><ul><li>The Chairman, SPSP, Tirupati </li></ul><ul><li>Medical &Para Medical Staff, TTD Hospitals </li></ul>

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