Research Proposal and Milestone


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Speaker: Jimmy Lu
Topics: Research Proposal and Milestone
Date: 2010.10.09


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Research Proposal and Milestone

  1. 1. The Research Proposal and Milestone Speaker : Jimmy Lu Advisor : Hsing Mei Web Computing Laboratory(WECO Lab) Computer Science and Information Engineering Department Fu Jen Catholic University
  2. 2. Outline 2015/1/30 2 WECO Lab, CSIE dept., FJU  The steps of defining the brain components  The network approach for modeling Alzheimer’s disease  Implementation details  Expected results  The milestone
  3. 3. What am I doing 2015/1/30 3 WECO Lab, CSIE dept., FJU  A brain simulator that simulates structural dynamics of the human brain.  A network dynamics approach for modeling the Alzheimer’s disease.  Define the brain components by utilizing object-oriented concept.
  4. 4. The Brain Components 2015/1/30 4 WECO Lab, CSIE dept., FJU  There are a lot of components in the human brain, it is extremely complex and makes me confused even I’ve studied neuroanatomy. Is there any reference to help me to define the components?  Wikipedia -> Human Brain
  5. 5. The Brain Components 2015/1/30 5 WECO Lab, CSIE dept., FJU  However it is still too many components that I can’t completely define them  Find out the most relevant part to the Alzheimer’s disease  Find out the most relevant part with acetylcholine
  6. 6. The Connections 2015/1/30 6 WECO Lab, CSIE dept., FJU  How about the connections?  Find out the connections from the context of the books of neruoanatomy or the wikipedia.  Use existing imaging tools to finds out the structural or functional connectivity. Getting imaging data first. Ex: Diffusion tensor imaging data.
  7. 7. How to utilizing OO concept? 2015/1/30 7 WECO Lab, CSIE dept., FJU  It seems that object-oriented concept are quite suitable for defining components of the human brain.  However it is not appropriate to use “inheritance” concepts only.  I need more powerful tools.  Design pattern[1]
  8. 8. Design Patterns 2015/1/30 8 WECO Lab, CSIE dept., FJU
  9. 9. Network approach model 2015/1/30 9 WECO Lab, CSIE dept., FJU  The internet, peer-to-peer, error and attack tolerance of complex networks[2], network damage models[3]  Key element: acetylcholine
  10. 10. How to verify the model 2015/1/30 10 WECO Lab, CSIE dept., FJU  Compare to image data
  11. 11. Expected Results 2015/1/30 11 WECO Lab, CSIE dept., FJU  A simple brain structural simulator which simulate the dynamics of brain structural connectivity of AD.  A model which describes how ACh effect on the brain of AD patients.  Library of the brain components and the connections.
  12. 12. Milestone 2015/1/30 12 WECO Lab, CSIE dept., FJU  October ~ February:  Define components and connections of the human brain  Implementation  Model  February ~ April:  Modification and verification  Thesis writing
  13. 13. Milestone 2015/1/30 13 WECO Lab, CSIE dept., FJU  May:  Prepare oral presentation  Thesis revision
  14. 14. 2015/1/30 WECO Lab, CSIE dept., FJU 14 1. Erich Gamma, Richard Helm, Ralph Johnson and John M. Vlissides, “Design Patterns: Elements of Reusable Object-Oriented Software”, Addison-Wesley Professional (1994) 2. Reka Albert, Hawoong Jeong and Albert-Laszlo Barabasi, “Error and attack tolerance of complex networks”, Nature 406 378-382 (2000) 3. C. J. Stam, W. de Haan, A. Daffertshofer, B. F. Jones, I. Manshanden, A. M. van Cappellen van Walsum, T. Montez, J. P. A. Verbunt, J. C. de Munck, B. W. van Dijk, H. W. Berendse and P. Scheltens, “Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer’s disease”, Brain 132 213–224 (2009)