Successfully reported this slideshow.
Your SlideShare is downloading. ×

WHAT IS THERAPEUTIC CLONING?#SciChallenge2017

Ad
Ad
Ad
Ad
Ad
Ad
Ad
Ad
Ad
Ad
Ad
Upcoming SlideShare
Somatic cell cloning
Somatic cell cloning
Loading in …3
×

Check these out next

1 of 18 Ad
Advertisement

More Related Content

Slideshows for you (20)

Similar to WHAT IS THERAPEUTIC CLONING?#SciChallenge2017 (20)

Advertisement

WHAT IS THERAPEUTIC CLONING?#SciChallenge2017

  1. 1. by Api Giulia and Cevasco Silvia
  2. 2. Cloning is the process by which is created a genetically identical copy of an organism. It may be naturally occurring or created in the laboratory.
  3. 3. REPRODUCTIVE TO GET AN ORGANISM WITH THE GENETIC HERRITAGE IDENTICAL TO THAT OF THE CORE DONOR THERAPEUTIC TO GET BY CORE’S TRANSFER FROM A ONE OOCYTE TO AN OTHER ONE, AND, NEXT FECUNDATION, AN IMMUNE EMBRYO FROM MITOCHONDRIAL ILLNESS OR FROM CHROMOSOMOPATHIES. PRODUCTIVE TO GET SELECTED ORGANS,TISSUES AND CELLULAR LINES. THE RESULT OF THE CLONING WOULD BE AN ORGANISM, WHICH IS GOTTEN BY THE TRASFER OF A NUCLEUS, AND WHICH HAS THE SAME CHOSEN GENETIC HARRITAGE : FROM THIS ORGANISM IT IS THOUGHT THAT IT COULD GET ORGANS,TISSUE AND CELLULAR LINES OF REQUEST GENETIC QUALITY. EXPERIMENTAL TO LEAVE SIMPLY OPEN TO THE RESEARCH THE POSSIBILITY TO DO NEW DISCOVERIES.
  4. 4. The therapeutic cloning is one of the many used methods to get STEM CELLS, to the scientific research and in the future to the care of degenerative illnesses. The used method for the therapeutic cloning foresees the denucleation of one cell and the insertion of a nucleus of a somatic cell. After the core’s implant it is simply stimulated the reproduction in vitro of the cell, to get new different stem cells with genetic herritage of the somatic cell. These could be used to care degenerative illness.
  5. 5. They’re cells that, by differentiation’s process, made other specialized cells. There are differents type of stem cells: TOTIPOTENT: which can make every kind of tissues; PLURIPOTENT: which can make every kind of tissues, eccept extra-embryonic tissue; OLIGOPOTENT: which can only make the cells of a certain tissue type; MULTIPOTENT : which can only make certain cells type; UNIOTENT: which can only make one type of cells. Stem cells more used in therapeuti cloning are embryonical cells, bone marrow’s cells, and skin, blood, umbilical cord’s cells.
  6. 6. IT CAN CARE DEGENERATIVE ILLNESSES AS TYPE 1 DIABETES… …OR IN THE FUTURE IT WILL BE ABLE TO CARE DEGENERATIVE ILLNESSES AS ALZHEIMER AND PARKINSON
  7. 7. IT CAN CARE DEGENERATIVE ILLNESSES AS TYPE 1 DIABETES… CAUSES AND CONSEQUENCES Type 1 Diabetes is an autoimmune illness because it is cased by the production of antibodies, wich attach pancreas’s cells, appoint to the production of insulin. The lack of this hormone, which regulates the presence of glucose in the blood, makes mode that the sugars, inserted in our body by nutrition , aren’t assimilated, but expelled with urine; for this the body has to made energy in other way, mainly by the lipid metabolism, and that involves the production of chetonic bodies, organic acidic make after lipid metabolism, and proteins.
  8. 8. Throughout the copy of stem cells →→ The stem cells can be used to substitute the missing or malfunctioning cells that pruduce insulin. The stem cells could be also used to keep in live the beta-pancreatic cells, which make insulin and defend them by the attack of the immune sistem.
  9. 9. The used method is divided into different phaeses: -The pancreas is taken from a brain dead donor -In the laboratory the organ is cleansed, the cells, called islet cells, which are going to be transplanted, are extracted and duplicated throughout the therapeutic cloning process. They are inglobated into a gelatinous substance (composed of plasm and a catalyst enzyme, called thrombin), this mixture is surgically inserted into the abdomen, and it attaches itself to the omentum (a filn which protects the organs in the abdominal are) and keeps the islets in the established position; -While the organism assorbs the gel, new blood vessels are created, which provid oxygen and indispensable substances for the survival of the injected cells. - Now the cells can perform their function and allow the correct production of insulin
  10. 10. - Thanks to therapeutic cloning, in Miami on 27th August 2015 the first pancreatic islets were transplanted, and it could be possible cure two people afflicted by type 1 diabetes. - On 9th june 2016 in Niguarda hospital, in Milan, it was made the first european transplant on 41-years-old man ADVANTAGES OF THIS LITTLE INVASIVE PROCEDURE ARE THE LESS RISK OF THE ‘’NEW ORGAN’’ REJECTION AND THAT PEOPLE WHO MAKE THIS WILL NOT HAVE TO EMPLOY INSULIN
  11. 11. The Alzheimer’s disease is a neurodegenerative illness, that damages the brain and involves the gradual decline of cognitive functiones, because it damages the brain’s area that monitors function like memory, thought and speech. Even if it doesen’t follow the Mendel’s rules, it is a genetic illness and nowdays we think that about 70% of people afflicted by dementia are also afflicted by Alzheimer’s disease.
  12. 12. By some tests we can understand the causes of Alzheimer’s appearance: When microglia, immune system’s cells, start to consume too much arginine (ammonoacid) those cells start to change and Alzheimer emerges.
  13. 13. The interrention is based on the duplication in vitro of the stem cells. Nevertheless, the experiment with this newmethod is still beginning. Studies are effected on laboratory’s mice only. Scientists inject in the brain of mice some stem cells, that will generate new connections between synapse. In this way, mice will recover memory. After the injection, the reseences found that animal’s brain have increased of 6% of the stem cells, that became nervous. While most of the stem cells have created new cells, that promote neuronal growth
  14. 14. Parkinson’S disease is a neurodegenerative illness that damnages functiones as the motion and equilibrium’s control (sometimes it compromises the leguage and it can cause sleep’s upset, depression stressand impulsive’s behavior). Because of deficit that it causes at motoric level, Parkinson disease is one of the illness call ‘’Motion’s disturbs’’. The avarage age when the disease appeares is around 58-60 years but it can alsoappear between 21 and 40 years ( it happenes infrequently). More rarely it appears before 20 years. Over 60 it attackes 1-2% of world population, and this percent touches 5% in people over 85 years-old
  15. 15. The causes of the illness are unknow. The illness borns when neurons of Substantia Nigra, deep brain’s area, degeneret and stop to produce the necessary quantity of dopamine. Dopamine is a neurotransmitter in charge of motion, working memory, speech, pleasure, sleep, some cognitive recognitions, and of concentration. Furthermore from morrow to brain it’s started to accumulate Alfa-Synuclein, a protein deemed liable of the illness’ spread in all the brain.
  16. 16. OLD THERAPY NEW THERAPY Before 2014, the transplant of stem cells happened trought the transplant of big and compact neuron’s blacks. However transplant neurons got sick too. The new treatment is based on twenty years of studies and foressees the injection of solution that contains a little amount of neuronal sem cells throught arteries.
  17. 17. After the assessment for the procedure’s sicurity, 20 patients were choosen and divided in two groups: one group, choosen by random way, got stem cells’ treatment, while the other one got a simulation of the real procedure, and after six months treatments were inverted. Stem cells, injected by arterial way, were taken by bone marrow and could slow down the illness progression, because they could produce growth factors which support sick nerv cells. ALL TWENTY PATIENT HAD GOT A BIG IMPROVING
  18. 18. WE HOPE YOU ENJOY OUR WORK! THANKS FOR WATCHING!!

Editor's Notes

  • Guarda tempo

×