WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues (2009)
<ul><li>Precursor  Lymphoid Neoplasms </li></ul><ul><li>Mature  B -Cell Neoplasms </li></ul><ul><li>Mature  T -Cell &  NK ...
 
 
Figure 14-4 Origin of lymphoid neoplasms. Stages of B- and T-cell differentiation from which specific lymphoid tumors emer...
<ul><li>Precursor Lymphoid Neoplasms </li></ul><ul><li>B lymphoblastic leukemia / lymphoma NOS </li></ul><ul><li>B lymphob...
Mature B-Cell Neoplasms <ul><li>Chronic lymphocytic leukemia / small lymphocytic lymphoma </li></ul><ul><li>B-cell prolymp...
Mature T-Cell & NK-Cell Neoplasms <ul><li>T-cell prolymphocytic leukemia </li></ul><ul><li>T-cell large granular lymphocyt...
Hodgkin lymphoma  <ul><li>Nodular lymphocyte-predominant Hodgkin lymphomas </li></ul><ul><li>Classic Hodgkin lymphomas </l...
Post-Transplant Lymphoproliferative Disorders (PTLD) <ul><li>Plasmacytic hyperplasia </li></ul><ul><li>Infectious mononucl...
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Linfomi

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  1. 1. WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues (2009)
  2. 2. <ul><li>Precursor Lymphoid Neoplasms </li></ul><ul><li>Mature B -Cell Neoplasms </li></ul><ul><li>Mature T -Cell & NK -Cell Neoplasms </li></ul><ul><li>Hodgkin lymphoma </li></ul><ul><li>Post-Transplant Lymphoproliferative Disorders (PTLD) </li></ul>CLASSIFICAZIONE DELLE NEOPLASIE LINFOPROLIFERATIVE ---------------------------------------------------------------------------------------- NHL HL
  3. 5. Figure 14-4 Origin of lymphoid neoplasms. Stages of B- and T-cell differentiation from which specific lymphoid tumors emerge are shown. Key: CLP, common lymphoid precursor; BLB, pre-B lymphoblast; NBC, naive B cell; MC, mantle B cell; GC, germinal center B cell; MZ, marginal zone B cell; DN, CD4/CD8 double negative pre-T cell; DP, CD4/CD8 double positive pre-T cell; PTC, peripheral T cell. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 14 July 2009 05:32 PM) © 2007 Elsevier
  4. 6. <ul><li>Precursor Lymphoid Neoplasms </li></ul><ul><li>B lymphoblastic leukemia / lymphoma NOS </li></ul><ul><li>B lymphoblastic leukemia / lymphoma with recurrent genetic abnormalities </li></ul><ul><li>B lymphoblastic leukemia / lymphoma with t(9;22); bcr-abl1 </li></ul><ul><li>B lymphoblastic leukemia / lymphoma with t(v;11q23); MLL rearranged </li></ul><ul><li>B lymphoblastic leukemia / lymphoma with t(12:21); TEL-AML1 & ETV6-RUNX1 </li></ul><ul><li>B lymphoblastic leukemia / lymphoma with hyperploidy </li></ul><ul><li>B lymphoblastic leukemia / lymphoma with hypodiploidy </li></ul><ul><li>B lymphoblastic leukemia / lymphoma with t(5;14); IL3-IGH </li></ul><ul><li>B lymphoblastic leukemia / lymphoma with t(1;19); E2A-PBX1 & TCF3-PBX1 </li></ul><ul><li>T lymphoblastic leukemia / lymphoma </li></ul>
  5. 7. Mature B-Cell Neoplasms <ul><li>Chronic lymphocytic leukemia / small lymphocytic lymphoma </li></ul><ul><li>B-cell prolymphocytic leukemia </li></ul><ul><li>Splenic marginal zone lymphoma </li></ul><ul><li>Hairy cell leukemia </li></ul><ul><li>Lymphoplasmacytic lymphoma / Waldenstrom macroglobulinemia </li></ul><ul><li>Heavy chain disease </li></ul><ul><li>Plasma cell myeloma </li></ul><ul><li>Solitary plasmacytoma of bone </li></ul><ul><li>Extraosseous plasmacytoma </li></ul><ul><li>Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type </li></ul><ul><li>Nodal marginal zone lymphoma </li></ul><ul><li>Follicular lymphoma </li></ul><ul><li>Primary cutaneous follicular lymphoma </li></ul><ul><li>Mantle cell lymphoma </li></ul><ul><li>Diffuse large B-cell lymphoma, NOS </li></ul><ul><li>(T-cell / histiocyte-rich type; primary CNS type ; primary leg skin type & EBV+ elderly type) </li></ul><ul><li>Diffuse large B-cell lymphoma with chronic inflammation </li></ul><ul><li>Lymphomatoid granulomatosis </li></ul><ul><li>Primary mediastinal large B-cell lymphoma </li></ul><ul><li>Intravascular large B-cell lymphoma </li></ul><ul><li>ALK+ large B-cell lymphoma </li></ul><ul><li>Plasmablastic lymphoma </li></ul><ul><li>Large B-cell lymphoma associated with HHV8+ Castleman disease </li></ul><ul><li>Primary effusion lymphoma </li></ul><ul><li>Burkitt lymphoma </li></ul><ul><li>B cell lymphoma, unclassifiable, Burkitt-like </li></ul><ul><li>B cell lymphoma, unclassifiable, Hodgkin lymphoma-like </li></ul>
  6. 8. Mature T-Cell & NK-Cell Neoplasms <ul><li>T-cell prolymphocytic leukemia </li></ul><ul><li>T-cell large granular lymphocytic leukemia </li></ul><ul><li>Chronic lymphoproliferative disorder of NK-cells. </li></ul><ul><li>Aggressive NK-cell leukemia </li></ul><ul><li>Systemic EBV+ T-cell lymphoproliferative disorder of childhood </li></ul><ul><li>Hydroa vacciniforme-like lymphoma </li></ul><ul><li>Adult T-cell lymphoma/leukemia </li></ul><ul><li>Extranodal T-cell/NK-cell lymphoma, nasal type </li></ul><ul><li>Enteropathy-associated T-cell lymphoma </li></ul><ul><li>Hepato-splenic T-cell lymphoma </li></ul><ul><li>Subcutaneous panniculitis-like T-cell lymphoma </li></ul><ul><li>Mycosis fungoides </li></ul><ul><li>S eza ry syndrome </li></ul><ul><li>Primary cutaneous CD30+ T-cell lymphoproliferative disorder </li></ul><ul><li>Primary cutaneous gamma-delta T-cell lymphoma </li></ul><ul><li>Peripheral T-cell lymphoma, NOS </li></ul><ul><li>Angioimmunoblastic T-cell lymphoma </li></ul><ul><li>Anaplastic large cell lymphoma, ALK+ type </li></ul><ul><li>Anaplastic large cell lymphoma, ALK- type </li></ul>
  7. 9. Hodgkin lymphoma <ul><li>Nodular lymphocyte-predominant Hodgkin lymphomas </li></ul><ul><li>Classic Hodgkin lymphomas </li></ul><ul><li>Nodular sclerosis Hodgkin lymphoma </li></ul><ul><li>Lymphocyte-rich classic Hodgkin lymphoma </li></ul><ul><li>Mixed cellularity Hodgkin lymphoma </li></ul><ul><li>Lymphocyte depletion Hodgkin lymphoma </li></ul>
  8. 10. Post-Transplant Lymphoproliferative Disorders (PTLD) <ul><li>Plasmacytic hyperplasia </li></ul><ul><li>Infectious mononucleosis like PTLD </li></ul><ul><li>Polymorphic PTLD </li></ul><ul><li>Monomorphic PTLD (B & T/NK cell types) </li></ul><ul><li>Classic HD type PTLD </li></ul>

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