Project of Liver Transplantation
Roll No:- 6
The liver is the largest organ, present inside the body just below the right
lung and the diaphragm. The liver lies close to the colon, the intestines and
the right kidney. It roughly weighs about 1.5 kg and is deep red in color due
to a rich blood supply. The liver performs several important functions:
It plays a major role in the metabolic process and subsequently in the
absorption of nutrients.
It secretes a substance called bile, necessary for breakdown of bigger fat
molecules into smaller forms. The bile reaches the small intestine through
the bile duct, during the digestive process.
Liver failure occurs when large parts of the liver become damaged beyond
repair and the liver is no longer able to function.
Liver failure is a life-threatening condition that demands urgent medical
care. Most often, liver failure occurs gradually and over many years.
However, a more rare condition known as acute liver failure occurs rapidly
(in as little as 48 hours) and can be difficult to detect initially.
Signs and symptoms of liver problems include:
•Abdomi Discolored skin and eyes that appear yellowish
•Nal pain and swelling
•Itchy skin that doesn't seem to go away
•Dark urine color
•Pale stool color
•Bloody or tar-colored stool
•Loss of appetite
To remove an unhealthy liver and replace it with the new one, liver
transplant surgeries are very effective.
However, just like any other medical procedure, the transplant surgery
needs adequate preparation. The patient must be aware of what he is going
to go through post surgery.
If medical therapy fails to succeed in treating these problems, a procedure
called Transjugular Intrahepatic Portosystemic Shunt (TIPS) can be
The traditional surgical bypass has a 10-60 percent mortality. Procedurerelated mortality due to TIPS is rare.
This non-surgical treatment involves creating a bypass in the liver using
balloon angioplasty and stent technology. X-ray guidance is used to find
the correct vessels, and to form a short pathway between them inside the
Donors can't be pregnant or overweight, although overweight candidates who
lose weight may be considered.
Donors should be:
•18 to 55 years of age
•In good health with no major medical or psychiatric illnesses
•Non-smokers for at least six weeks prior to surgery
•Able to understand and comply with instructions for surgery preparation and
Types of donors for Liver
Live Donor – A live donor is a living person who is healthy
Cadeveric Donor – A cadaveric donor is a brain dead person.
Presented by DEEPA