Iodoacetate: irreversible inhibitor of
enzyme glyceraldehyde-3-p dehydrogenase.
It combines with –SH group at the active
s...
Examples of Suicidal Inhibition
 Allopurinol: oxidized product

Alloxanthine is more potent and effective
inhibitor of Xa...
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My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
My enzyme ii
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My enzyme ii

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My enzyme ii

  1. 1. Iodoacetate: irreversible inhibitor of enzyme glyceraldehyde-3-p dehydrogenase. It combines with –SH group at the active site of enzyme.  Fluoride: inhibit the enzyme Enolase and stop glycolysis.  Disulfirum [Antabuse]: used in T/t of alcoholism, drug irreversibly inhibit the enzyme aldehyde dehydrogenase, causing accumulation of acetaldehyde and sickening effect. 
  2. 2. Examples of Suicidal Inhibition  Allopurinol: oxidized product Alloxanthine is more potent and effective inhibitor of Xanthine oxidase.  Aspirin: acetylates serine residue of COX active site & inhibit PG synthesis.  5-FU: converted to flurodeoxyuridylate(Fdump) by salvage pathway which inhibit thymidylate synthase.
  3. 3. *

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