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In Nigeria, substance abuse has gradually become a cause for concern due to the alarming increase in the consumption of psychoactive substances over the years. This has therefore warranted the need to find an effective and sustainable solution to the problem before its gets out of hand. A stakeholders’ consultative forum on substance abuse which attracted important stakeholders in the field was convened in March 2011 and issues bordering on substance abuse in Nigeria and the development of effective and sustainable intervention were discussed and decisions on the way forward taken. Taking into consideration that stakeholders play important roles at the various stages of planning, implementation and evaluation of substance abuse interventions, it is important to understand their views on issues relevant to the development of these interventions. The researchers therefore conducted this study with the aim of providing information on stakeholders’ views about substance abuse in Nigeria, as well as their opinions on the strategies for developing effective and sustainable substance abuse interventions in the country; in view that it would serve as a framework for making decisions on issues related to the development of substance abuse control interventions in Nigeria and also for conducting further studies on issues highlighted in the study.