Leukocytoclastic vasculitis

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Leukocytoclastic vasculitis

  1. 1. Case Report . Cutaneous Leukocytoclastic Vasculitis associated with Dexibuprofen F. Peral Rubio, M.D. Department of Dermatology Complejo Hospitalario Universitario, Badajoz, Spain. www.dermatoblog.com
  2. 2. Cutaneous Leukocytoclastic Vasculitis associated with Dexibuprofen <ul><li>A 65 -year-old fe male </li></ul><ul><li>P alpable purpura of the trunk and extremities. </li></ul><ul><li>He had been diagnosed with p olyarthrosis 2 months earlier , initiating treatment with non steroidal anti inflammatory (dexibuprofen) . </li></ul>
  3. 3. Cutaneous Leukocytoclastic Vasculitis associated with Dexibuprofen <ul><li>A purpuric appeared on the lower and upper extremities. The skin lesions spread progressively over the entire body, and several lesions coalesced, resulting in blisters and ulcers . </li></ul>
  4. 10. Cutaneous Leukocytoclastic Vasculitis associated with Dexibuprofen <ul><li>Blood investigations showed increased levels of acute phase reactants . </li></ul><ul><li>Investigations done to exclude other causes of this rash include hepatitis B surface antigen, hepatitis C IgG antibody, presence of cryoglobulin and anti-neutrophil cytoplasmic antibody (ANCA) and Anti-nuclear antibody; all were negative. </li></ul><ul><li>There was no evidence of microscopic haematuria or casts on microscopic examination of the urine. </li></ul><ul><li>Skin biopsy showed that small vessels in the dermis were surrounded by neutrophils and nuclear debris. Red cell extravasate was present. There were no eosinophils and few lymphocytes were seen. </li></ul><ul><li>Immunofluorescence was negative for antibodies or immune-complexes. </li></ul>
  5. 11. Cutaneous Leukocytoclastic Vasculitis associated with Dexibuprofen <ul><li>The patient was treated with predniso na ( 6 0 mg) the dose was reduced on progressive improvement of the vasculitis lesions. </li></ul>
  6. 12. Case Report . Cutaneous Leukocytoclastic Vasculitis associated with Dexibuprofen F. Peral Rubio, M.D. Department of Dermatology Complejo Hospitalario Universitario, Badajoz, Spain. www.dermatoblog.com

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