Kaposi variceliform erupcion

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Kaposi variceliform erupcion

  1. 1. Darier's disease complicated by Kaposi's varicelliform eruption due to herpes simplex virus www.dermatoblog.com
  2. 3. Darier's disease
  3. 4. Darier's disease
  4. 5. Darier's disease complicated by Kaposi's varicelliform eruption <ul><li>Kaposi varicelliform eruption (KVE) is the name given to a distinct cutaneous eruption caused by herpes simplex virus (HSV) type 1, HSV-2, coxsackievirus A16, or vaccinia virus that infects a preexisting dermatosis. </li></ul><ul><li>Most commonly, it is caused by a disseminated HSV infection in patients with atopic dermatitis and, for this reason, is often referred to as eczema herpeticum. </li></ul>
  5. 6. Darier's disease complicated by Kaposi's varicelliform eruption <ul><li>Kaposi varicelliform eruption (KVE) begins as a sudden eruption of painful; edematous; often crusted or hemorrhagic vesicles, pustules, or erosions in areas of the preexisting dermatosis. </li></ul><ul><li>The eruption continues to spread over 7-10 days and may be associated with a high temperature, malaise, and lymphadenopathy. </li></ul><ul><li>Umbilicated vesiculopustules that progress to punched-out erosions in the setting of a widespread dermatosis, is virtually pathognomonic for Kaposi varicelliform eruption. </li></ul>
  6. 7. Darier's disease complicated by Kaposi's varicelliform eruption <ul><li>Significant morbidity and mortality can be associated with Kaposi varicelliform eruption (KVE) due to HSV infection. </li></ul><ul><li>However, with the introduction of intravenous acyclovir, in addition to systemic/topical antibiotic treatment, the mortality rate has decreased from as high as 50% to less than 10%. </li></ul><ul><li>Significant complications may arise from keratoconjuctivitis, and rare cases of multiple-organ involvement with meningitis and encephalitis have been reported. </li></ul>
  7. 8. Darier's disease complicated by Kaposi's varicelliform eruption <ul><li>Darier's disease is an autosomal dominant dermatosis. </li></ul><ul><li>It may rarely be complicated by localized or widespread cutaneous viral infections. </li></ul><ul><li>It is postulated that a defect in cell-mediated immunity may contribute to this predisposition. </li></ul>
  8. 9. Darier's disease complicated by Kaposi's varicelliform eruption <ul><li>Skin barrier dysfunction, found in conditions like Atopic Dermatitis, ichthyosis, pemphigus, and Darier disease, is also a factor in the development of KVE. </li></ul><ul><li>KVE has also been reported after epidermal disruption caused by vigorous scrubbing, dermabrasion, burns, and skin grafts. </li></ul>
  9. 10. Darier's disease complicated by Kaposi's varicelliform eruption due to herpes simplex virus www.dermatoblog.com

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